Processes, Volume 8, Issue 2 (February 2020) – 130 articles
Cover Story (view full-size image): Self‐synchronizing oscillatory metabolism was revealed in continuous culture of Clostridium pasteurianum by the real-time measurement of gas production (CO2 and H2) and redox potential, explaining the variable product profile. The oscillations in CO2 and H2 production and redox potential were in sync with glycerol in the CSTR, providing strong evidence that the mechanism is involved in the regulation of the oxidative pathway of glycerol metabolism, involving cycles of enzyme inhibition and activation by pathway intermediates and/or redox equivalents. The importance of these findings lies both in understanding regulation and in developing a productive industrial biobutanol production process from biodiesel-derived crude glycerol.View this paper.
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