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Biomedicines, Volume 8, Issue 1 (January 2020) – 17 articles
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Cover Story (view full-size image) ALDH2 down-regulation (down arrow) or inhibition (dashed red lines) into mitochondria of [...] Read more. ALDH2 down-regulation (down arrow) or inhibition (dashed red lines) into mitochondria of endothelial cells (ECs) leads to inefficient aldehyde catabolism, affecting ECs functions and accelerating senescence. Senescence itself might further aggravate endothelial dysfunction. Age-related cardiovascular diseases (atherosclerosis and coronary artery disease, CAD) and cerebrovascular unit dysfunction contributing to neurodegenerative disorders (Cerebral Amyloid Angiopathy, CAA, and Alzheimer’s disease, AD) are linked to ALDH2 impairment.View this paper.