Next Article in Journal
Meta-Analysis of Hypoxic Transcriptomes from Public Databases
Next Article in Special Issue
Viral Vector-Based Melanoma Gene Therapy
Previous Article in Journal
The Gut Microbiome and Type 2 Diabetes Mellitus: Discussing A Complex Relationship
 
 
Review

Emerging Concepts and Challenges in Rheumatoid Arthritis Gene Therapy

1
Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119048 Moscow, Russia
2
Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov First Moscow State Medical University, 119435 Moscow, Russia
3
Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia
4
Department of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University, 119991 Moscow, Russia
5
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia
*
Author to whom correspondence should be addressed.
Biomedicines 2020, 8(1), 9; https://doi.org/10.3390/biomedicines8010009
Received: 3 December 2019 / Revised: 3 January 2020 / Accepted: 7 January 2020 / Published: 9 January 2020
(This article belongs to the Special Issue Gene Therapy Coming of Age)
Rheumatoid arthritis (RA) is a systemic inflammatory joint disease affecting about 1% of the population worldwide. Current treatment approaches do not ensure a cure for every patient. Moreover, classical regimens are based on nontargeted systemic immune suppression and have significant side effects. Biological treatment has advanced considerably but efficacy and specificity issues remain. Gene therapy is one of the potential future directions for RA therapy, which is rapidly developing. Several gene therapy trials done so far have been of moderate success, but experimental and genetics studies have yielded novel targets. As a result, the arsenal of gene therapy tools keeps growing. Currently, both viral and nonviral delivery systems are used for RA therapy. Herein, we review recent approaches for RA gene therapy. View Full-Text
Keywords: rheumatoid arthritis; gene therapy; AAV; miRNA; siRNA; lncRNA; circRNA; monoclonal antibodies; gene delivery; CIA; clinical trials rheumatoid arthritis; gene therapy; AAV; miRNA; siRNA; lncRNA; circRNA; monoclonal antibodies; gene delivery; CIA; clinical trials
Show Figures

Figure 1

MDPI and ACS Style

Deviatkin, A.A.; Vakulenko, Y.A.; Akhmadishina, L.V.; Tarasov, V.V.; Beloukhova, M.I.; Zamyatnin Jr., A.A.; Lukashev, A.N. Emerging Concepts and Challenges in Rheumatoid Arthritis Gene Therapy. Biomedicines 2020, 8, 9. https://doi.org/10.3390/biomedicines8010009

AMA Style

Deviatkin AA, Vakulenko YA, Akhmadishina LV, Tarasov VV, Beloukhova MI, Zamyatnin Jr. AA, Lukashev AN. Emerging Concepts and Challenges in Rheumatoid Arthritis Gene Therapy. Biomedicines. 2020; 8(1):9. https://doi.org/10.3390/biomedicines8010009

Chicago/Turabian Style

Deviatkin, Andrei A., Yulia A. Vakulenko, Ludmila V. Akhmadishina, Vadim V. Tarasov, Marina I. Beloukhova, Andrey A. Zamyatnin Jr., and Alexander N. Lukashev. 2020. "Emerging Concepts and Challenges in Rheumatoid Arthritis Gene Therapy" Biomedicines 8, no. 1: 9. https://doi.org/10.3390/biomedicines8010009

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop