Table of Contents
Biomedicines, Volume 6, Issue 1 (March 2018)
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Cover Story (view full-size image) Single nucleotide polymorphisms (SNPs) in GJA4 (the gene that codes for Cx37) have previously been [...] Read more. Single nucleotide polymorphisms (SNPs) in GJA4 (the gene that codes for Cx37) have previously been shown to be associated with myocardial infarction and atherosclerosis. In this research, we demonstrate that polymorphisms in connexin Cx37, are differentially distributed in patients with and without secondary lymphedema, following surgery for breast cancer. The results in this study also confirm that the number of lymph nodes being invaded by breast tumours had a statistically significant impact on the presence of lymphedema, and that increased lymph node invasion correlated with an increased probability of secondary lymphedema. Our results show that SNPs in GJA4 could be used as novel predictive biomarkers for the predisposition to secondary lymphedema in breast cancer patients, following surgical intervention. View the paper