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Biomedicines 2018, 6(1), 27; https://doi.org/10.3390/biomedicines6010027

The Application of Gene Expression Profiling in Predictions of Occult Lymph Node Metastasis in Colorectal Cancer Patients

1
Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Live Diseases, Shahid Beheshti University of Medical Sciences, Tehran 19839-63113, Iran
2
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 19839-63113, Iran
3
Colorectal Division of Department of Surgery, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran 19839-63113b, Iran
4
School of Allied Health Sciences, Faculty of Health and Life Sciences, De Montfort University, Leicester LE1 9BH, UK
5
School of Biological Sciences, University of Portsmouth, Portsmouth PO1 2UP, UK
6
Department of Biological Sciences, University of Chester, Chester CH1 4BJ, UK
*
Authors to whom correspondence should be addressed.
Received: 31 December 2017 / Revised: 24 February 2018 / Accepted: 1 March 2018 / Published: 2 March 2018
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Abstract

A key factor in determining the likely outcome for a patient with colorectal cancer is whether or not the tumour has metastasised to the lymph nodes—information which is also important in assessing any possibilities of lymph node resection so as to improve survival. In this review we perform a wide-range assessment of literature relating to recent developments in gene expression profiling (GEP) of the primary tumour, to determine their utility in assessing node status. A set of characteristic genes seems to be involved in the prediction of lymph node metastasis (LNM) in colorectal patients. Hence, GEP is applicable in personalised/individualised/tailored therapies and provides insights into developing novel therapeutic targets. Not only is GEP useful in prediction of LNM, but it also allows classification based on differences such as sample size, target gene expression, and examination method. View Full-Text
Keywords: gene expression profiling (GEP); lymph node metastasis (LNM); colorectal cancer (CRC) gene expression profiling (GEP); lymph node metastasis (LNM); colorectal cancer (CRC)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Peyravian, N.; Larki, P.; Gharib, E.; Nazemalhosseini-Mojarad, E.; Anaraki, F.; Young, C.; McClellan, J.; Ashrafian Bonab, M.; Asadzadeh-Aghdaei, H.; Zali, M.R. The Application of Gene Expression Profiling in Predictions of Occult Lymph Node Metastasis in Colorectal Cancer Patients. Biomedicines 2018, 6, 27.

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