Next Article in Journal
The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice
Next Article in Special Issue
Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms
Previous Article in Journal
Update in Systemic and Targeted Therapies in Gastrointestinal Oncology
Open AccessReview

VHL and Hypoxia Signaling: Beyond HIF in Cancer

by Jing Zhang 1,* and Qing Zhang 1,2,*
Department of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, NC 27599, USA
Department of Pharmacology, UNC-Chapel Hill, Chapel Hill, NC 27599, USA
Authors to whom correspondence should be addressed.
Biomedicines 2018, 6(1), 35;
Received: 24 February 2018 / Revised: 12 March 2018 / Accepted: 16 March 2018 / Published: 19 March 2018
(This article belongs to the Special Issue Hypoxia)
Von Hippel-Lindau (VHL) is an important tumor suppressor that is lost in the majority of clear cell carcinoma of renal cancer (ccRCC). Its regulatory pathway involves the activity of E3 ligase, which targets hypoxia inducible factor α (including HIF1α and HIF2α) for proteasome degradation. In recent years, emerging literature suggests that VHL also possesses other HIF-independent functions. This review will focus on VHL-mediated signaling pathways involving the latest identified substrates/binding partners, including N-Myc downstream-regulated gene 3 (NDRG3), AKT, and G9a, etc., and their physiological roles in hypoxia signaling and cancer. We will also discuss the crosstalk between VHL and NF-κB signaling. Lastly, we will review the latest findings on targeting VHL signaling in cancer. View Full-Text
Keywords: VHL; Hypoxia; ccRCC VHL; Hypoxia; ccRCC
Show Figures

Graphical abstract

MDPI and ACS Style

Zhang, J.; Zhang, Q. VHL and Hypoxia Signaling: Beyond HIF in Cancer. Biomedicines 2018, 6, 35.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop