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Biomedicines, Volume 13, Issue 9

September 2025 - 275 articles

Cover Story: Iron is indispensable for life yet toxic in excess. Iron utilization is essential to normal physiologic processes across cell types. This paper explores the molecular mechanisms that maintain systemic iron balance and how their disruption leads to multi-organ disease. We outline iron's "lifecycle", key regulatory pathways, and the consequences of their failure, along with iron’s impact on systems including bone marrow, CNS, liver, kidneys, gonads, and endocrine tissues. In each of these, the dangers of overload are described, linking molecular missteps to diverse and potentially chronic syndromes. Finally, emerging therapies such as gene editing and mimetics aimed at restoring iron equilibrium are also discussed. View this paper
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Articles (275)

  • Review
  • Open Access
1,416 Views
24 Pages

Pharmaco-Epigenetics and Epigenetic Drugs in Type 2 Diabetes: Can Epigenetics Predict Drug Efficiency?

  • Senzosenkosi Surprise Mkhize,
  • Anil Amichund Chuturgoon,
  • Terisha Ghazi and
  • Kgothatso Eugene Machaba

16 September 2025

Type 2 Diabetes Mellitus (T2DM) is increasingly affecting individuals across various age groups due to inadequate insulin action and secretion. It has become the leading cause of mortality worldwide, with an estimated 9.3% of the global population cu...

  • Article
  • Open Access
877 Views
16 Pages

Structural Proteins at Neuromuscular Junction Are Downgraded While NRG1 and Agrin Gene Expression Increases After Muscle Injury

  • Jurandyr Pimentel Neto,
  • Lara Caetano Rocha-Braga,
  • Matheus Bertanha Fior,
  • Paula Oliveira Camargo and
  • Adriano Polican Ciena

16 September 2025

Background/Objectives: The neuromuscular junction (NMJ) is the area where peripheral nerves communicate with muscle tissue. Muscle injury can occur as part of an acute degenerative process at the NMJ. This study aims to investigate the remodeling of...

  • Review
  • Open Access
4,204 Views
13 Pages

Recent Progress in Keloid Mechanism and Treatment: A Comprehensive Review

  • Lucia Merlino,
  • Mattia Dominoni,
  • Martina Rita Pano,
  • Marianna Francesca Pasquali,
  • Roberto Senatori,
  • Grazia Zino and
  • Barbara Gardella

16 September 2025

Keloids are abnormal fibroproliferative responses in the skin that often occur without an apparent injury. Their pathogenesis remains incompletely understood, though genetic, environmental, and biochemical factors are believed to contribute. Topical...

  • Article
  • Open Access
910 Views
12 Pages

High PEEP Increases Airway Dead Space and Decreases Alveolar Ventilation: A New Technique for Volumetric Capnography

  • Masashi Zuiki,
  • Kazunori Watanabe,
  • Norihiro Iwata,
  • Rika Mitsuno,
  • Madoka Konishi,
  • Akio Yamano,
  • Eisuke Ichise,
  • Hidechika Morimoto,
  • Kanae Hashiguchi and
  • Tatsuji Hasegawa
  • + 1 author

16 September 2025

Background/Objectives: Identifying the optimal positive end-expiratory pressure (PEEP) is a major challenge in implementing strategies to prevent ventilator-induced lung injury in newborns. In this study, we assessed the validity of volumetric capnog...

  • Systematic Review
  • Open Access
578 Views
21 Pages

Antenatal Sildenafil for Congenital Diaphragmatic Hernia: A Systematic Review and Bayesian Meta-Analysis of Preclinical Studies

  • Tamara M. Hundscheid,
  • Ilaria Amodeo,
  • Giacomo Cavallaro,
  • Carlijn R. Hooijmans,
  • František Bartoš and
  • Eduardo Villamor

16 September 2025

Background: In congenital diaphragmatic hernia (CDH), pulmonary hypoplasia and pulmonary hypertension are major causes of morbidity and mortality. Antenatal treatment with sildenafil has shown some promising protective effects in experimental CDH, bu...

  • Article
  • Open Access
553 Views
10 Pages

ABCA1, ADIPOQ, APOE, FSTL4, and KCNQ1 Gene DNA Methylation Correlates with Lipid Profiles in Mexican Populations

  • Karla E. Tello-Ortega,
  • María A. Romero-Tlalolini,
  • Angélica Martínez-Hernández,
  • Elizabeth Ortiz-Sánchez,
  • Cecilia Contreras-Cubas,
  • Humberto García-Ortiz,
  • Francisco Barajas-Olmos,
  • Lorena Orozco and
  • Federico Centeno

16 September 2025

Background: Dyslipidemia, a significant modifiable risk factor for cardiovascular disease (CVD), represents a major global health challenge, particularly influenced by complex genetic and environmental interactions, mainly in indigenous populations....

  • Article
  • Open Access
791 Views
13 Pages

The Impact of Pulmonary Hypertension on Hospitalization Risk in Adults with Respiratory Syncytial Virus Infection

  • Mayuri Mudgal,
  • Aseem Rai Bhatnagar,
  • Aneesh Kumar Vasudevan,
  • Ajeetha Priya Gajendiran,
  • Venkatesh Gondhi,
  • Swetha Balaji,
  • Shanjai Krishnan Murugan and
  • Kulothungan Gunasekaran

16 September 2025

Background/Objectives: Respiratory syncytial virus (RSV) infection can lead to significant complications, particularly among those with underlying cardiovascular and pulmonary complications. Patients with pulmonary hypertension (PH) are susceptible t...

  • Correction
  • Open Access
418 Views
2 Pages

16 September 2025

In the original publication [...]

  • Article
  • Open Access
1,042 Views
26 Pages

Chitosan–Hydrazone-Modified Calcium Phosphate Scaffolds: Fabrication, Characterization, and Drug Delivery Potential

  • Teodora Jakovljević,
  • Jelena Stanisavljević,
  • Julijana Stevanović,
  • Miloš Petković,
  • Ivana Z. Matić,
  • Miloš Papić,
  • Suzana Živanović,
  • Tamara Matić,
  • Vukašin Ugrinović and
  • Djordje Janaćković
  • + 2 authors

15 September 2025

Background/Objectives: Recent advancements in biomaterials aimed at closely mimicking natural biological tissues hold great promise for hard tissue regeneration and controlled drug release due to their superior physical, chemical, and biological prop...

  • Article
  • Open Access
616 Views
19 Pages

15 September 2025

Background: This study assessed whether repeated monitoring of peripheral and organ perfusion predicts mortality in severe SARS-CoV-2 patients. Methods: Peripheral perfusion was measured with finger oxygen saturation (SpO2), capillary refill time (CR...

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Biomedicines - ISSN 2227-9059