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Biomedicines, Volume 13, Issue 9

September 2025 - 275 articles

Cover Story: Iron is indispensable for life yet toxic in excess. Iron utilization is essential to normal physiologic processes across cell types. This paper explores the molecular mechanisms that maintain systemic iron balance and how their disruption leads to multi-organ disease. We outline iron's "lifecycle", key regulatory pathways, and the consequences of their failure, along with iron’s impact on systems including bone marrow, CNS, liver, kidneys, gonads, and endocrine tissues. In each of these, the dangers of overload are described, linking molecular missteps to diverse and potentially chronic syndromes. Finally, emerging therapies such as gene editing and mimetics aimed at restoring iron equilibrium are also discussed. View this paper
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Articles (275)

  • Article
  • Open Access
1 Citations
632 Views
14 Pages

Mammographic Calcifications in Lung Transplant Recipients: Prevalence and Evolution

  • Jonathan Saenger,
  • Jasmin Happe,
  • Caroline Maier,
  • Bjarne Kerber,
  • Ela Uenal,
  • Denise Bos,
  • Thomas Frauenfelder and
  • Andreas Boss

22 September 2025

Objective: To investigate the prevalence and progression of macrocalcifications or sporadic scattered microcalcifications, breast arterial calcifications (BAC) and grouped microcalcifications in women undergoing lung transplantation (LTX). Materials...

  • Systematic Review
  • Open Access
2 Citations
2,077 Views
25 Pages

Comparative Efficacy of Platelet-Rich Plasma, Autologous Serum, and Artificial Tears in Dry Eye Disease: A Systematic Review and Meta-Analysis

  • Alexandra Laura Mederle,
  • Diana Andrei,
  • Laura Andreea Ghenciu,
  • Emil Robert Stoicescu,
  • Roxana Iacob and
  • Ovidiu Alin Haţegan

22 September 2025

Background/Objectives: Dry eye disease (DED) is a prevalent, complex disorder with a major impact on patients’ quality of life. While artificial tears (AT) are still the first-line treatment, their effectiveness is often limited in moderate-to-...

  • Article
  • Open Access
696 Views
19 Pages

The Diagnostic Role of Novel Echocardiography Indices and Arterial Stiffness in Diabetic Cardiomyopathy

  • Elina Khattab,
  • Stefanos Sokratous,
  • Michaela Kyriakou,
  • Georgios Parpas,
  • Ioannis Korakianitis,
  • Paraskevi Papakyriakopoulou and
  • Nikolaos P. E. Kadoglou

22 September 2025

Background/Objectives: Diabetic cardiomyopathy (DBCM) is characterized by cardiac dysfunction in the absence of ischemic heart disease, hypertension, or valvular disease, often manifesting as heart failure with preserved ejection fraction (HFpEF). Ea...

  • Review
  • Open Access
1,454 Views
16 Pages

Heparin Binding Protein in Sepsis—A Comprehensive Overview of Pathophysiology, Clinical Usage and Utility as Biomarker

  • Foteini Tasouli,
  • Eleni Georgopoulou,
  • Christodoulos Chatzigrigoriadis,
  • Dimitrios Velissaris and
  • Christos Michailides

22 September 2025

The heparin-binding protein (HBP) is an enzymatically inactive protein of the serine protease family that plays an important role in host response to stress, especially infection and sepsis. It is produced by activated neutrophils due to a variety of...

  • Review
  • Open Access
1,627 Views
18 Pages

Allogeneic NKG2D CAR-T Cell Therapy: A Promising Approach for Treating Solid Tumors

  • Sabir A. Mukhametshin,
  • Elvina M. Gilyazova,
  • Damir R. Davletshin,
  • Irina A. Ganeeva,
  • Ekaterina A. Zmievskaya,
  • Vitaly V. Chasov,
  • Alexsei V. Petukhov,
  • Aigul Kh. Valiullina,
  • Sheila Spada and
  • Emil R. Bulatov

22 September 2025

Chimeric Antigen Receptor (CAR)-T cell therapy has transformed the treatment landscape of cancer, yet major challenges remain in enhancing efficacy, reducing adverse effects, and expanding accessibility. Autologous CAR-T cells, derived from individua...

  • Editorial
  • Open Access
860 Views
7 Pages

22 September 2025

Human stem cell research is entering a stage where disease modeling, translational applications, and clinical therapies are increasingly connected. This editorial provides an overview of the contributions included in this Special Issue, titled &ldquo...

  • Article
  • Open Access
1 Citations
681 Views
15 Pages

Localization and Expression of Renin–Angiotensin System Receptors in Lung from Transplant Patients: A Case-Control Study

  • Andresa Thomé Silveira,
  • Lucas Sagrillo Fagundes,
  • Juliane Flor,
  • Isabel Amaral Martins,
  • Laura Bastos Otero,
  • Laura Tibola Marques da Silva,
  • Lorenzo Santana Maciel,
  • Sarah Eller,
  • Giuliano Rizzotto Guimarães and
  • Fabíola Adelia Perin
  • + 2 authors

21 September 2025

Objective: We aimed to assess the expression and localization of renin-angiotensin system (RAS) receptors in lung tissue and the plasma concentration of related peptides in IPF patients. Materials and Methods: This case–control study involved 1...

  • Article
  • Open Access
1,038 Views
12 Pages

21 September 2025

Objective: IgG4-Related Orbital Disease (IgG4-ROD) is an incompletely understood differential of idiopathic orbital inflammatory syndrome (IOIS). Accurate separation guides therapy and prognosis. This retrospective study also profiles its clinical fe...

  • Article
  • Open Access
832 Views
16 Pages

The Role of Antifibrotic Therapy in Pulmonary Fibrosis and Lung Cancer: A Multicenter Retrospective Analysis

  • Francesco Rocco Bertuccio,
  • Nicola Baio,
  • Fabio Perrotta,
  • Donato Lacedonia,
  • Vito D’Agnano,
  • Andrea Bianco,
  • Giulia Scioscia,
  • Pasquale Tondo,
  • Maria Pia Foschino Barbaro and
  • Chandra Bortolotto
  • + 2 authors

21 September 2025

Background: Patients with fibrotic interstitial lung disease (ILD) are at increased risk of lung cancer, yet the impact of antifibrotic therapy on oncologic outcomes remains unclear. Objective: This study aimed to explore associations between antifib...

  • Review
  • Open Access
1 Citations
2,458 Views
25 Pages

A Clinical Review of the Connections Between Diabetes Mellitus, Periodontal Disease, and Cardiovascular Pathologies

  • Otilia Țica,
  • Ioana Romanul,
  • Gabriela Ciavoi,
  • Vlad Alin Pantea,
  • Ioana Scrobota,
  • Lucian Șipoș,
  • Cristian Marius Daina and
  • Ovidiu Țica

20 September 2025

Background: Diabetes mellitus (DM), periodontal disease (PD), and cardiovascular disease (CVD) are highly prevalent global health conditions with overlapping pathophysiological mechanisms. Emerging evidence suggests a bidirectional and synergistic re...

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Biomedicines - ISSN 2227-9059