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Biomedicines, Volume 13, Issue 5

May 2025 - 258 articles

Cover Story: Medication-related osteonecrosis of the jaw (MRONJ) is a severe side effect in patients treated with antiresorptive or antiangiogenic drugs. This study investigates the effectiveness of photobiomodulation (PBM) therapy in treating MRONJ, with a focus on complete recovery in Stage I and its supportive role in more advanced stages. Using a low-level 635 nm diode laser, PBM was shown to significantly reduce inflammation and pain and promote tissue repair. Patients with early-stage disease achieved full healing, while those with advanced MRONJ experienced meaningful symptom relief and an improved quality of life. PBM may reduce the need for extensive surgery and serve as a valuable adjunctive therapy. View this paper
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Articles (258)

  • Article
  • Open Access
882 Views
13 Pages
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Blood Serum from Patients with Acute Leukemia Inhibits the Growth of Bone Marrow Multipotent Mesenchymal Stromal Cells

  • Nataliya Petinati,
  • Aleksandra Sadovskaya,
  • Irina Shipounova,
  • Alena Dorofeeva,
  • Nina Drize,
  • Anastasia Vasilyeva,
  • Olga Aleshina,
  • Olga Pokrovskaya,
  • Larisa Kuzmina and
  • Sofia Starchenko
  • + 4 authors
Biomedicines2025, 13(5), 1265;https://doi.org/10.3390/biomedicines13051265

21 May 2025

Background/Objectives: Acute leukemia (AL) alters both hematopoiesis and the bone marrow stromal microenvironment. Attempts to develop a culture of multipotent mesenchymal stromal cells (MSCs) from AL patients’ bone marrow are not always succes...

Full Article
  • Communication
  • Open Access
1,554 Views
14 Pages
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Last Resort? Rationale for Comprehensive Molecular Analysis in Treatment-Refractory R/M HNSCC: A Case Report of Remarkable Response to Sacituzumab Govitecan Following Molecular and Functional Characterization

  • Henrike Barbara Zech,
  • Philippe Schafhausen,
  • Leonie Ramke,
  • Janna-Lisa Velthaus,
  • Simon Kreutzfeldt,
  • Daniel Hübschmann,
  • Kai Rothkamm,
  • Carsten Bokemeyer,
  • Anna Sophie Hoffmann and
  • Stefan Fröhling
  • + 4 authors
Biomedicines2025, 13(5), 1266;https://doi.org/10.3390/biomedicines13051266

21 May 2025

Background/Objectives: In recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC), the overall prognosis is poor, and systemic treatment options remain limited. While precision therapy approaches have revolutionized treatment strategie...

Full Article
  • Article
  • Open Access
1 Citations
1,288 Views
13 Pages
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Gut Microbiota Dysbiosis in Japanese Female Patients with Nontuberculous Mycobacteria-Associated Lung Disease: An Observational Study

  • Kanako Kono,
  • Yutaka Kozu,
  • Shun Yokota,
  • Kouta Hatayama,
  • Kenji Mizumura,
  • Shuichiro Maruoka,
  • Hiroaki Masuyama and
  • Yasuhiro Gon
Biomedicines2025, 13(5), 1264;https://doi.org/10.3390/biomedicines13051264

21 May 2025

Background/Objectives: Nontuberculous mycobacterial pulmonary disease (NTM-PD) is treated using a combination of multiple antimicrobial agents and prolonged therapy; however, recurrence and reinfection rates remain high. Susceptibility to NTM-PD is n...

Full Article
  • Review
  • Open Access
2 Citations
3,070 Views
21 Pages
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Extracellular Vesicles as Emerging Therapeutic Strategies in Spinal Cord Injury: Ready to Go

  • Jiali Jiang,
  • Ziyi Wang,
  • Qinghua Bao,
  • Shenyuan Chen,
  • Wenrong Xu and
  • Jiajia Jiang
Biomedicines2025, 13(5), 1262;https://doi.org/10.3390/biomedicines13051262

21 May 2025

Spinal cord injury (SCI) is a prevalent central nervous system disorder that causes significant disability and mortality. Unfortunately, due to the complex pathophysiological mechanisms involved, there remains a critical paucity of effective therapeu...

Full Article
  • Article
  • Open Access
964 Views
10 Pages
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Interleukin-37 Suppresses the Function of Type 2 Follicular Helper T in Allergic Rhinitis

  • Xi Luo,
  • Yanhui Wen,
  • Xiangqian Qiu,
  • Lifeng Zhou,
  • Qingxiang Zeng and
  • Wenlong Liu
Biomedicines2025, 13(5), 1263;https://doi.org/10.3390/biomedicines13051263

21 May 2025

Background: Allergic rhinitis (AR) is triggered by immunoglobulin E (IgE)-mediated immune responses to airborne allergens. Recent studies highlight the pivotal role of T follicular helper 2 (Tfh2) cells in IgE production. Interleukin-37 (IL-37) has e...

Full Article
  • Review
  • Open Access
3 Citations
2,799 Views
20 Pages
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Spatial Heterogeneity of Intratumoral Microbiota: A New Frontier in Cancer Immunotherapy Resistance

  • Qiwen Tan,
  • Xiongjing Cao,
  • Falong Zou,
  • Hanwenchen Wang,
  • Lijuan Xiong and
  • Shenghe Deng
Biomedicines2025, 13(5), 1261;https://doi.org/10.3390/biomedicines13051261

21 May 2025

The intratumoral microbiota, as an important component of the tumor microenvironment, is increasingly recognized as a key factor in regulating responses to cancer immunotherapy. Recent studies have revealed that the intratumoral microbiota is not uni...

Full Article
  • Review
  • Open Access
7 Citations
3,478 Views
22 Pages
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Chronic Inflammation and Immune Dysregulation in Metabolic-Dysfunction-Associated Steatotic Liver Disease Progression: From Steatosis to Hepatocellular Carcinoma

  • Young-Min Jee,
  • Jeong-Yoon Lee and
  • Tom Ryu
Biomedicines2025, 13(5), 1260;https://doi.org/10.3390/biomedicines13051260

21 May 2025

Background/Objectives: Metabolic-dysfunction-associated steatotic liver disease (MASLD) progresses from hepatic steatosis to hepatocellular carcinoma (HCC) as a result of systemic immunometabolic dysfunction. This review summarizes the key roles of t...

Full Article
  • Article
  • Open Access
1,802 Views
12 Pages
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Beating Heart Coronary Artery Bypass Grafting with Preemptive Impella™ 5.5 Assist Device in Ischemic Cardiomyopathy

  • Francesco Cabrucci,
  • Massimo Baudo,
  • Yoshiyuki Yamashita,
  • Amanda Yakobitis,
  • Courtney Murray and
  • Gianluca Torregrossa
Biomedicines2025, 13(5), 1259;https://doi.org/10.3390/biomedicines13051259

21 May 2025

Background: Choosing the best surgical approach for coronary revascularization in patients with ischemic cardiomyopathy and low EF is complex. Several strategies have been adopted, including on- and off-pump CABG, the use of IABP, and the combination...

Full Article
  • Article
  • Open Access
1,676 Views
11 Pages
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Two-Staged Sequential Management of Post-LASIK Ectasia: Under-Flap Corneal Cross-Linking for Stabilization Followed by Flap Surface Topography-Guided PRK for Visual Optimization

  • Avi Wallerstein,
  • Brandon Bellware,
  • Mark Cohen,
  • Pierre Demers and
  • Mathieu Gauvin
Biomedicines2025, 13(5), 1258;https://doi.org/10.3390/biomedicines13051258

21 May 2025

Background/Objectives: To evaluate the efficacy, accuracy, safety, and long-term stability of topography-guided photorefractive keratectomy (TGPRK) in eyes where post-LASIK (PLE) ectasia progression was stabilized with under-flap corneal crosslinking...

Full Article
  • Review
  • Open Access
4 Citations
6,219 Views
16 Pages
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Platelet-Rich Plasma (PRP) in Reproductive Medicine: A Critical Review of PRP Therapy in Low-Reserve and Premature Ovarian Insufficiency

  • Efthalia Moustakli,
  • Anastasios Potiris,
  • Athanasios Zikopoulos,
  • Athanasios Zachariou,
  • Spyridon Topis,
  • Periklis Panagopoulos,
  • Ekaterini Domali,
  • Peter Drakakis and
  • Sofoklis Stavros
Biomedicines2025, 13(5), 1257;https://doi.org/10.3390/biomedicines13051257

21 May 2025

Background: Intraovarian platelet-rich plasma (PRP) has emerged as a novel intervention at the intersection of reproductive medicine and regenerative biology. As women with diminished ovarian reserve (DOR), poor response to stimulation, or premature...

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