Novel Progress in Cancer Immunotherapy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 772

Special Issue Editor


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Guest Editor
Regina Elena National Cancer Institute, Hospital Physiotherapy Institutes (IRCCS), Rome, Italy
Interests: exosomes; immunotherapy; bladder cancer; lung cancer; breast cancer
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Special Issue Information

Dear Colleagues,

Immunotherapy revolutioned the cancer treatment landscape with advancing developments in oncoimmunology. However, only a low percentage of patients clinically benefit from immune therapeutic agents. Therefore, there is an urgent need to understand the signaling pathways that regulate the cross-talk between tumor cells and immune cells and the relevant treatment-driven resistance mechanisms. Dissecting these dynamic interactions will allow us to discover new targetable molecules in order to develop therapeutic agents or combination therapies  to enhance the anti-tumor immune response. In addition, the identification of novel predictive and prognostic immune biomarkers of cancer progression and immunotherapy response will improve the patients’outcome.  

The Special Issue “Novel Progress in Cancer Immunotherapy” welcomes research articles and reviews including in vitro and in vivo studies on immune checkpoint inhibitors, anti-cancer vaccines, antibody-based therapies and adoptive cell therapies to widely explore the rapidly moving field of immunotherapy.

Dr. Sheila Spada
Guest Editor

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Keywords

  • immune checkpoint blockers
  • CAR-T
  • solid tumor
  • liquid tumor
  • cancer therapy
  • immunology

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Published Papers (1 paper)

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Review

20 pages, 4500 KiB  
Review
Spatial Heterogeneity of Intratumoral Microbiota: A New Frontier in Cancer Immunotherapy Resistance
by Qiwen Tan, Xiongjing Cao, Falong Zou, Hanwenchen Wang, Lijuan Xiong and Shenghe Deng
Biomedicines 2025, 13(5), 1261; https://doi.org/10.3390/biomedicines13051261 - 21 May 2025
Viewed by 226
Abstract
The intratumoral microbiota, as an important component of the tumor microenvironment, is increasingly recognized as a key factor in regulating responses to cancer immunotherapy. Recent studies have revealed that the intratumoral microbiota is not uniformly distributed but instead exhibits significant spatial heterogeneity, with [...] Read more.
The intratumoral microbiota, as an important component of the tumor microenvironment, is increasingly recognized as a key factor in regulating responses to cancer immunotherapy. Recent studies have revealed that the intratumoral microbiota is not uniformly distributed but instead exhibits significant spatial heterogeneity, with its distribution patterns influenced by factors such as tumor anatomy, local immune status, and therapeutic interventions. This spatial heterogeneity not only alters the interactions between microbes and the host immune system but may also reshape the immunogenic and immunosuppressive landscapes of tumors. The enrichment or depletion of microbiota in different tumor regions can influence immune cell infiltration patterns, metabolic pathway activities, and immune checkpoint molecule expression, thereby driving the development of resistance to immunotherapy. Moreover, certain bacterial metabolites form concentration gradients between the tumor core and margins, thereby regulating immune cell function. Therefore, understanding and manipulating the spatial distribution of intratumoral microbiota, particularly in resistant patients, holds promise for developing new strategies to overcome immunotherapy resistance. In the future, precise modulation strategies targeting microbial spatial heterogeneity, such as engineered bacterial vectors, probiotic combinations, and phage therapy, may open new avenues for immunotherapy. Full article
(This article belongs to the Special Issue Novel Progress in Cancer Immunotherapy)
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