2026 December - 8 articles
Advances in genomics and proteomics have greatly expanded our understanding of plant biology by providing comprehensive insights into the molecular mechanisms underlying growth, development, and adaptation to environmental challenges [...]
Human skin aging comprises changes in extracellular matrix, epidermal differentiation and barrier function, redox balance, protein homeostasis, inflammation, and senescence. This critical narrative review uses structured descriptive charting of publi...
Background: Sex differences influence venous thromboembolism (VTE) risk and clinical course, but corresponding differences in circulating proteomic profiles among individuals with established VTE remain incompletely characterized. We investigated fem...
Protein post-translational modifications (PTMs) greatly expand proteome complexity by regulating protein activity, localization, stability, and intermolecular interactions. While advances in mass spectrometry have enabled the large-scale characteriza...
Background: Proteoforms are the critical functional species that drive biological processes. However, conventional proteogenomic (“shotgun”) analyses discard relevant proteoform-level information through bulk protein digestion. This study...
Background: Lung adenocarcinoma (LUAD) shows marked heterogeneity in its immune microenvironment, which may contribute to differences in disease-free survival (DFS) and clinical outcome. Although current LUAD classifications are largely based on geno...
Classical liquid chromatography–tandem mass spectrometry (LC-MS/MS) remains a cornerstone of proteomics, but deep profiling of complex biofluids is constrained by the extreme dynamic range of protein abundance and low sample throughput. Emergin...
Background: Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) is a serine/threonine kinase that exhibits oncogenic activity in various cancers. Despite the established role of MAP3K3 in signal transduction, its phosphosignaling landscape, inc...
