Clinical Proteomics: Unravelling Drug and Disease Mechanisms (Fifth Edition)
A special issue of Proteomes (ISSN 2227-7382). This special issue belongs to the section "Proteomics of Human Diseases and Their Treatments".
Deadline for manuscript submissions: 30 June 2026
Special Issue Editor
Interests: drug mechanisms, proteomics; mass spectrometry; signaling pathways; cancer; phosphorylation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Proteomics has undergone transformative advancements over recent years. This includes technological advances enhancing the speed and sensitivity of mass spectrometers for discovery-based approaches and advances in targeted affinity proteomics. This has been complemented by the adoption of automated and modular workflows in sample preparation and chromatography. These advances have paved the way for the development of single-cell spatio-temporal proteomics profiling with wider applications in understanding mode of action of drugs, disease mechanisms alongside the discovery of new biomarkers. Computational advances and new proteogenomic workflows have led to widespread adoption of DIA-based approaches in the analysis of clinical samples for biomarker discovery. We are also witnessing a growing trend for the adoption of antibody-independent approaches such as high-resolution multiplexed “Parallel Reaction Monitoring” (PRM) for biomarker or target validation. These technological advances are shaping up the future and addressing challenges such as (1) single-cell-level proteomic analysis of clinical samples and (2) discovering novel proteoforms relevant to understanding mode of action of drugs, disease progression and staging.
For this Special Issue, we look forward to receiving original clinical proteomics studies and review articles focused on (1) the underlying mechanisms of disease progression using human tissues or representative cell lines, (2) biomarker discovery studies using quantitative proteomics, and (3) mass spectrometry-based biomarker validation studies, as well as (4) the use of proteomics to discover modes of action of new and existing drugs.
Dr. Vikram Sharma
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Proteomes is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mass spectrometry
- data independent acquisition
- drugs
- mechanisms
- clinical proteomics
- disease proteomics
- proteoforms
- PTMs
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
