2026 September - 18 articles
Obesity, type 2 diabetes (T2D), metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction-associated steatohepatitis (MASH), and dual-etiology metabolic dysfunction-associated alcohol-related liver disease (MetALD) form...
Periodontal regeneration requires the reconstruction of root cementum, periodontal ligament, and alveolar bone, which are frequently disrupted by periodontitis, trauma, and other inflammatory conditions. Although periodontal ligament stem cells (PDLS...
Background: Chronic stress contributes to the development of cardiometabolic, malignant, and other chronic diseases through cumulative multisystem physiological dysregulation, conceptualized as allostatic load (AL). However, traditional AL relies on...
Background: Modern proteomics faces a critical bottleneck: the vast discrepancy between the number of genes in the human genome and the exponentially greater variety of functional proteoforms that actually drive biological processes. Methods: Our pap...
Background: Dysregulated cell migration leading to metastasis remains the primary cause of cancer-related mortality. It has been challenging to understand how cells regulate migration. We have previously created the first selective inhibitor of cell...
Drought and heat stresses are among the most important environmental constraints limiting maize (Zea mays L.) productivity worldwide. Over the past two decades, advances in mass spectrometry-based proteomics have generated extensive datasets describi...
Background: Beckers muscular dystrophy (BMD) is a clinically heterogeneous dystrophinopathy caused by in-frame mutations in the dystrophin gene, resulting in variable disease severity. This variability limits the effectiveness of standardized functio...
Background: Seed dormancy is crucial for plant survival and agricultural productivity, yet its molecular mechanisms, particularly the role of maternal effects, remain poorly understood. Methods: In this study, we applied a SWATH-based, label-free, qu...
Background: Mechanosensitive ion channels PIEZO1 and PIEZO2 are key mediators of mechanotransduction, which converts physical forces into cellular signals involved in proprioception, touch, vascular function, and other physiological processes. Mutati...
Background: Koalas are a vulnerable marsupial species with unique reproductive traits. Efforts to develop assisted breeding technologies have been hindered by a limited understanding of maternal recognition of pregnancy and physiological changes indu...
Background: Adult Schistosoma mansoni parasites inhabit the hepatic portal system of the vertebrate host, their deposited eggs causing granulomatous pathology in both the intestines and liver. In the intestines, egg secretions drive inflammatory proc...
Background: Autoimmune diseases (AIDs) are associated with increased cardiovascular risk. However, specific protein mediators linking AIDs to major adverse cardiovascular events (MACE) and cardiovascular death (CV death) remain unexplored. This study...
Background: Increasing summer seawater temperatures pose challenges for Atlantic salmon aquaculture, while brain region-specific responses to elevated temperature remain poorly understood. Methods: Atlantic salmon in the warm treatment (WT) underwent...
Background: Comparative proteome analysis can reveal functional conservation and divergence among orthologous proteins, with important implications for pharmacology and toxicology. Protein language models (PLMs) may capture sequence-derived functiona...
Background: Multi-drug resistant Gram-negative bacteria (GNB) are major contributors to the antimicrobial resistance (AMR) burden. AMR mechanisms are primarily mediated by proteoforms; therefore, proteomic analyses of GNB offers a significant advanta...
Background: Distinguishing genuine kinase–substrate motifs from background noise is a growing challenge, as mass spectrometry (MS)-based global phosphoproteomics identifies a rapidly expanding set of phosphorylation sites. One of the major limi...
Background: cMGVB is a graphical processing unit (GPU)-enabled implementation of the computational proteomics data analysis toolset MGVB. MGVB was released in 2025 as a Linux program designed to run on multi-node servers. It utilizes a novel algorith...
As global ecosystems and food systems face unprecedented anthropogenic and climatic challenges, there is a demand for an integrated understanding of biological systems. Proteomics has emerged as a definitive approach offering a direct view of the mol...
