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Understanding the Pathogenesis of Spondyloarthritis

Department of Biology, School of Sciences and Humanities, Nazarbayev University, Nur-Sultan 010000, Kazakhstan
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Biomolecules 2020, 10(10), 1461; https://doi.org/10.3390/biom10101461
Received: 30 June 2020 / Revised: 7 September 2020 / Accepted: 8 September 2020 / Published: 20 October 2020
(This article belongs to the Special Issue Molecular Basis of Autoimmunity Diseases)
Spondyloarthritis comprises a group of inflammatory diseases of the joints and spine, with various clinical manifestations. The group includes ankylosing spondylitis, reactive arthritis, psoriatic arthritis, arthritis associated with inflammatory bowel disease, and undifferentiated spondyloarthritis. The exact etiology and pathogenesis of spondyloarthritis are still unknown, but five hypotheses explaining the pathogenesis exist. These hypotheses suggest that spondyloarthritis is caused by arthritogenic peptides, an unfolded protein response, HLA-B*27 homodimer formation, malfunctioning endoplasmic reticulum aminopeptidases, and, last but not least, gut inflammation and dysbiosis. Here we discuss the five hypotheses and the evidence supporting each. In all of these hypotheses, HLA-B*27 plays a central role. It is likely that a combination of these hypotheses, with HLA-B*27 taking center stage, will eventually explain the development of spondyloarthritis in predisposed individuals. View Full-Text
Keywords: spondyloarthritis; HLA-B*27; pathogenesis; inflammation; arthritogenic peptides; unfolded protein response; ERAP1; gut dysbiosis spondyloarthritis; HLA-B*27; pathogenesis; inflammation; arthritogenic peptides; unfolded protein response; ERAP1; gut dysbiosis
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MDPI and ACS Style

Sharip, A.; Kunz, J. Understanding the Pathogenesis of Spondyloarthritis. Biomolecules 2020, 10, 1461. https://doi.org/10.3390/biom10101461

AMA Style

Sharip A, Kunz J. Understanding the Pathogenesis of Spondyloarthritis. Biomolecules. 2020; 10(10):1461. https://doi.org/10.3390/biom10101461

Chicago/Turabian Style

Sharip, Aigul, and Jeannette Kunz. 2020. "Understanding the Pathogenesis of Spondyloarthritis" Biomolecules 10, no. 10: 1461. https://doi.org/10.3390/biom10101461

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