Table of Contents
Metabolites, Volume 9, Issue 7 (July 2019)
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Cover Story (view full-size image) Protein glycosylation is a ubiquitous form of protein modification. It plays a central role in most [...] Read more. Protein glycosylation is a ubiquitous form of protein modification. It plays a central role in most complex disorders. Yet, the biological processes involved in establishing the human “glycan code” are not well understood. Until we develop tools to study the glycoproteome, we are forced to analyze the glycome and the proteome independently, which makes them difficult to combine. In this study, we linked these two omics layers for the first time by correlating the levels of over one thousand blood-circulating proteins with more than 100 protein N-glycan traits. Our study included almost 400 samples from an ethnically diverse population of Arab, South-Asian, Filipino, and European ancestries and reveals complex relationships between the blood proteome and its N-glycome, suggesting new avenues for the investigation of their roles and functions in the many associated diseases. View this paper.