Scientia Pharmaceutica, Volume 72, Issue 4

The impact of variations in the wet granulation step during the manufacturing process on the in-vitro and in-vivo performance of ibuprofen sustained release matrix tablets was investigated. Two batches were produced under different wet granulation co...

In certain situations of peptic ulcers ampicillin has been co-administered with bismuth carbonate with an implication for adsorption of the ampicillin. To quantify this effect the kinetics and extent of adsorption of ampicillin by some commonly used...

The spheres were prepared by the desolvation technique combined with gravitational sedimentation of droplets of methylcellulose gel suspensions with the addition of 25% quinidine adsorbate on the potato starch and 5% hydrophilic agents such as Span 8...

1-(4-fluoropheny1)-4-[3-(2-,3- and 4-alkyloxyphenylcarbamoyloxy)-2-hydroxypropyl]piperaziniumchlorides, with one to four carbon atoms in the alkoxy group on aromatic ring have been synthesized as the derivatives of substituted phenylcarbamic acid. Th...

Synthesis of 5-acylhydrazine derivatives of ethyl 3-methyl-4-isothiazolo-carboxylate and their transformations under alcoxides influence have been described and presented.

All trans retinoic acid (RA), derived from the oxidative metabolism of dietary retinol (vitamin A) and β carotene, contributes to the growth and differentiation of mammalian epithelial tissues. RA is rapidly cleared from the plasma and sudenly metabo...