Scientia Pharmaceutica, Volume 69, Issue 4

The combination of 5-lipoxygenase (5-LOX) inhibition and retinoid activity in one molecule could be a suitable too1 for the topical psoriasis therapy. The anellation of the 5-LOX inhibitor 1 with the tetramethylcyclohexane moity to the arotinoid stru...

4-Hydroxyimino-oxazolidin-2-ones (3) were prepared by hydroxylaminolysis of 4-alkoxy-3-oxazolin-2-ones (2). Treatment of 3a with ethyl chloroformate in a molar ratio of 1:1 afforded 6, whereas the reaction 3a with two equivalents of ethyl chloroforma...

New thiasubstituted sulfonyl analogues of spirohydantoins were synthesized and tested for their anticonvulsant effects. In low concentrations they had no anticonvulsant activities, in higher ones they were neurotoxic.

The reaction of amiloride hydrochloride (1.HCI) with bromine in alkaline solution generated a yellow-brown dehydrogenation product, which tumed out as 3-(3-amino-I,2,4-oxadiazol-5-yl)-5-chloro-2,6-pyrazinediamine (2). The structure was deduced from t...

The cytoprotective agent amifostine (AMI) is capable to protect healthy cells (contrary to tumor cells) due to higher activity of alkaline phosphatase at the membrane site of normal cells. In seven clinical trials the influence of AMI on the pharmaco...

Capillary electrophoresis is a versatile analytical technique for the determination of a very widespread range of compounds. Many applications for the separation of different pharmaceuticals, ions, herbicides and biomolecules such as DNA, proteins an...

Photodegradation of meloxicam is studied placing special emphasis on the investigation of the correlation between the sample concentration and the stability. For quantitation a HPTLC assay was developed. The stability indicating capability ofthe assa...

The synthesis of thiolactime 4 and first studies on the syntheses of other thiolactimes with different substituted thieno[2,3-b][1,4]thiazine moieties are described as well as the syntheses of structurally modified amidines 10 - 14 with the same basi...

Synthesis and aldose reductase inhibitory profile of certain parabanic acid derivatives 1a-p is described. Also, the antihyperglycaemic potential of these compounds was studied. The most active inhibitors in this series were compounds 1g, 1p, and 10...

A new series of 4(3H)-quinazolinone analogs bearing 6-iodo and 2-thioether functions were synthesized and screened for their in vitro antitumor activity. Eight compounds were identified as active anticancer agents. 2-Mercapto-3-benzyl-4-thioxo-6-iodo...