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Sci. Pharm.
Volume 69
Issue 4
10.3797/scipharm.aut-01-204
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Article

Synthesis, Selective Aldose Reductase Inhibitory Profile and Antihyperglycaemic Potential of Certain Parabanic Acid Derivatives

by
M. Nabil Aboul-Enein
1,*,
A. EI-Azzouny
1,
Y. A. Maklad
2 and
M. I. Attia
1
1
Department of Pharmaceutical Sciences, Pharm. Chem. group, National Research Centre, Dokki, Cairo, Egypt
2
Department of Pharmaceutical Sciences, Pharmacology group, National Research Centre, Dokki, Cairo, Egypt
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2001, 69(4), 329-350; https://doi.org/10.3797/scipharm.aut-01-204
Submission received: 29 March 2001 / Accepted: 5 June 2001 / Published: 28 December 2001
Versions Notes

Abstract

Synthesis and aldose reductase inhibitory profile of certain parabanic acid derivatives 1a-p is described. Also, the antihyperglycaemic potential of these compounds was studied. The most active inhibitors in this series were compounds 1g, 1p, and 10 which showed inhibitory activity, 36.6,90 and 91% respectively, at concentration 1 x 1 0−4. Their IC50 were 2 x 10−6, 7.5 x 1 0-8 and 5 x 10-8, respectively. Compound 10 exhibited pronounced antihyperglycaemic effect.
Keywords: Diabetes mellitus; aldose reductase; aldose reductase inhibitors; parabanic acid derivatives Diabetes mellitus; aldose reductase; aldose reductase inhibitors; parabanic acid derivatives

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MDPI and ACS Style

Aboul-Enein, M.N.; EI-Azzouny, A.; Maklad, Y.A.; Attia, M.I. Synthesis, Selective Aldose Reductase Inhibitory Profile and Antihyperglycaemic Potential of Certain Parabanic Acid Derivatives. Sci. Pharm. 2001, 69, 329-350. https://doi.org/10.3797/scipharm.aut-01-204

AMA Style

Aboul-Enein MN, EI-Azzouny A, Maklad YA, Attia MI. Synthesis, Selective Aldose Reductase Inhibitory Profile and Antihyperglycaemic Potential of Certain Parabanic Acid Derivatives. Scientia Pharmaceutica. 2001; 69(4):329-350. https://doi.org/10.3797/scipharm.aut-01-204

Chicago/Turabian Style

Aboul-Enein, M. Nabil, A. EI-Azzouny, Y. A. Maklad, and M. I. Attia. 2001. "Synthesis, Selective Aldose Reductase Inhibitory Profile and Antihyperglycaemic Potential of Certain Parabanic Acid Derivatives" Scientia Pharmaceutica 69, no. 4: 329-350. https://doi.org/10.3797/scipharm.aut-01-204

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