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Article

Zur Farbreaktion von Amiloridhydrochlorid Ph. Eur. †

by 1,*, 1, 2, 3 and 3
1
Institut für Pharmazeutische Chemie der Technischen Universität Braunschweig, Beethovenstraße 55, D-38106 Braunschweig
2
Institut für Anorganische und Analytische Chemie der Technischen Universität Braunschweig, Hagenring 30, D-38106 Braunschweig
3
Institut für Pharmazeutische Chemie und Pharmazeutische Technologie der Karl-Franzens-Universität Graz, Schubertstraße 1, A-8010 Graz
*
Author to whom correspondence should be addressed.
Herrn Univ.-Prof. Dr. Dr. h.c. W. Fleischhacker mit den besten Wünschen zum 70. Geburtstag gewidmet.
Sci. Pharm. 2001, 69(4), 275-287; https://doi.org/10.3797/scipharm.aut-01-199
Received: 19 August 2001 / Accepted: 7 September 2001 / Published: 28 December 2001
The reaction of amiloride hydrochloride (1.HCI) with bromine in alkaline solution generated a yellow-brown dehydrogenation product, which tumed out as 3-(3-amino-I,2,4-oxadiazol-5-yl)-5-chloro-2,6-pyrazinediamine (2). The structure was deduced from the MS and the NMR spectra of 2 with the help of comparisons with corresponding spectra of amiloride (1) and reference substances 3 - 5. The agreement of all relevant data of the product and of authentical oxadiazolylpyrazine 2 as weil as the accomplished X-ray analysis confirmed the postulated structure. The mechanism of the formation of 2 is also discussed.
Keywords: Amiloride; colour reaction with bromine; 2,6-Pyrazinediamine; 3-(3-amino-l,2,4-oxadiazol-5-yl); 5-chloro; X-rayanalysis; MS analysis; and NMR analysis Amiloride; colour reaction with bromine; 2,6-Pyrazinediamine; 3-(3-amino-l,2,4-oxadiazol-5-yl); 5-chloro; X-rayanalysis; MS analysis; and NMR analysis
MDPI and ACS Style

Görlitzerl, K.; Huth, S.; Jones, P.G.; Gößnitzer, E.; Wendelin, W. Zur Farbreaktion von Amiloridhydrochlorid Ph. Eur. Sci. Pharm. 2001, 69, 275-287. https://doi.org/10.3797/scipharm.aut-01-199

AMA Style

Görlitzerl K, Huth S, Jones PG, Gößnitzer E, Wendelin W. Zur Farbreaktion von Amiloridhydrochlorid Ph. Eur. Scientia Pharmaceutica. 2001; 69(4):275-287. https://doi.org/10.3797/scipharm.aut-01-199

Chicago/Turabian Style

Görlitzerl, Klaus, Silke Huth, Peter G. Jones, Edith Gößnitzer, and Winfried Wendelin. 2001. "Zur Farbreaktion von Amiloridhydrochlorid Ph. Eur." Scientia Pharmaceutica 69, no. 4: 275-287. https://doi.org/10.3797/scipharm.aut-01-199

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