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Volume 69
Issue 4
10.3797/scipharm.aut-01-203
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Synthese von einigen potentiellen NO-Synthase-Inhibitoren mit Thieno[2,3-b] [1,4l thiazin-Grundgerüst

by
M. E. Galanski
,
N. Böhler
and
T. Erker
*
Institut für Pharmazeutische Chemie der Universität Wien, Althanstraβe 14, A-1090 Wien, Österreich
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2001, 69(4), 321-328; https://doi.org/10.3797/scipharm.aut-01-203
Submission received: 29 August 2001 / Accepted: 3 October 2001 / Published: 28 December 2001
Versions Notes

Abstract

The synthesis of thiolactime 4 and first studies on the syntheses of other thiolactimes with different substituted thieno[2,3-b][1,4]thiazine moieties are described as well as the syntheses of structurally modified amidines 10 - 14 with the same basic structure. The thieno[2,3-b][1,4]thiazine derivatives were prepared by reacting methyl 5-chloro-4-nitro-2-thiophencarboxylate with ethyl thioglycolate followed by reductive cyclisation to 6, which was either first saponified and then treated with Lawesson reagent to obtain thiolactame 8 or directly reacted to thiolactame 9. Reaction of 9 with various amines led to the desired products 10 - 14. which will undergo pharmacological testing on NO synthase inhibiting activities.
Keywords: Thieno[2.3-b][1,4]thiazines; NO Synthase Inhibitors Thieno[2.3-b][1,4]thiazines; NO Synthase Inhibitors

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MDPI and ACS Style

Galanski, M.E.; Böhler, N.; Erker, T. Synthese von einigen potentiellen NO-Synthase-Inhibitoren mit Thieno[2,3-b] [1,4l thiazin-Grundgerüst
. Sci. Pharm. 2001, 69, 321-328. https://doi.org/10.3797/scipharm.aut-01-203

AMA Style

Galanski ME, Böhler N, Erker T. Synthese von einigen potentiellen NO-Synthase-Inhibitoren mit Thieno[2,3-b] [1,4l thiazin-Grundgerüst
. Scientia Pharmaceutica. 2001; 69(4):321-328. https://doi.org/10.3797/scipharm.aut-01-203

Chicago/Turabian Style

Galanski, M. E., N. Böhler, and T. Erker. 2001. "Synthese von einigen potentiellen NO-Synthase-Inhibitoren mit Thieno[2,3-b] [1,4l thiazin-Grundgerüst
" Scientia Pharmaceutica 69, no. 4: 321-328. https://doi.org/10.3797/scipharm.aut-01-203

APA Style

Galanski, M. E., Böhler, N., & Erker, T. (2001). Synthese von einigen potentiellen NO-Synthase-Inhibitoren mit Thieno[2,3-b] [1,4l thiazin-Grundgerüst
. Scientia Pharmaceutica, 69(4), 321-328. https://doi.org/10.3797/scipharm.aut-01-203

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