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Diseases, Volume 12, Issue 8

2024 August - 28 articles

Cover Story: Throughout life, the exposome encompasses all internal and external exposures, including biological, chemical, physical, psychological, relational, and socio-economic factors. It is a useful means for examining the duration and intensity of these exposures and their interactions. Environmental factors such as air pollution, race, and socio-economic status contribute significantly to metabolic, cardiovascular, and neurodegenerative diseases, infertility, and cancer. The gut microbiota, which is strongly influenced by diet, also plays a crucial role. Advanced methods measure contaminants but often overlook the cumulative risk of multiple chemicals. A One Health approach considering human, animal, and environmental health is essential for effectively preventing and managing chronic non-communicable diseases. View this paper
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Articles (28)

  • Article
  • Open Access
1,991 Views
13 Pages

22 August 2024

This study was designed to examine the changes in emergency room visits in otolaryngology, head and neck surgery, during the COVID-19 pandemic. The study included 11,277 patients who presented to a tertiary care hospital (ER) and an emergency practic...

  • Review
  • Open Access
9 Citations
2,193 Views
12 Pages

COVID-19, Nutrients and Lifestyle Eating Behaviors: A Narrative Review

  • Giovanni Cangelosi,
  • Sara Morales Palomares,
  • Paola Pantanetti,
  • Alessia De Luca,
  • Federico Biondini,
  • Cuc Thi Thu Nguyen,
  • Stefano Mancin,
  • Marco Sguanci and
  • Fabio Petrelli

22 August 2024

Background: COVID-19 infection, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), quickly emerged as the most significant event of the new millennium. A balanced diet seems to ensure the proper functioning of the immune system a...

  • Article
  • Open Access
4 Citations
6,302 Views
13 Pages

Effectiveness of an Acupuncture Steam-Warming Eye Mask on Dry Eye Disease in Visual Display Terminal Users: A Prospective Randomized Controlled Trial

  • Chia-Yi Lee,
  • Shun-Fa Yang,
  • Ching-Hsi Hsiao,
  • Chi-Chin Sun,
  • Chao-Kai Chang,
  • Jing-Yang Huang and
  • Yih-Shiou Hwang

22 August 2024

We aim to evaluate the effectiveness of an acupuncture steam-warming eye mask (ASEM) on dry eye disease (DED) in visual display terminal (VDT) users. This prospective randomized clinical trial included VDT users with DED-related features who were ran...

  • Article
  • Open Access
1 Citations
1,766 Views
10 Pages

Left Ventricular Reverse Remodeling after Surgical Aortic Valve Replacement for Aortic Regurgitation—An Explorative Study

  • Zsuzsanna Arnold,
  • Alexander Elnekheli,
  • Daniela Geisler,
  • Thomas Aschacher,
  • Verena Lenz,
  • Bernhard Winkler,
  • Reinhard Moidl and
  • Martin Grabenwöger

21 August 2024

Background: The timing of treatment for chronic aortic valve regurgitation (AR), especially in asymptomatic patients, is gaining attention since less invasive strategies have become available. The aim of the present study was to evaluate left ventric...

  • Article
  • Open Access
2,482 Views
8 Pages

The Incidence of Clostridioides difficile Infection in the Post-COVID-19 Era in a Hospital in Northern Greece

  • Maria Terzaki,
  • Dimitrios Kouroupis,
  • Charalampos Zarras,
  • Dimitrios Molyvas,
  • Chrysi Michailidou,
  • Panagiotis Pateinakis,
  • Konstantina Mpani,
  • Prodromos Soukiouroglou,
  • Eleftheria Paida and
  • Athina Pyrpasopoulou
  • + 3 authors

20 August 2024

Clostridioides difficile infection (CDI) has evolved to be the most significant cause of healthcare-associated diarrhoea and one of the leading representatives of healthcare-associated infections, with a high associated mortality. The aim of this ret...

  • Communication
  • Open Access
3,247 Views
11 Pages

High-Risk HPV Screening Initiative in Kosovo—A Way to Optimize HPV Vaccination for Cervical Cancer

  • Jessica L. Bentz,
  • Rachael E. Barney,
  • Natalia Georgantzoglou,
  • Suzana Manxhuka-Kerliu,
  • Vlora Ademi Ibishi,
  • Brikene Dacaj-Elshani,
  • Suyapa Bejarano,
  • Paul E. Palumbo,
  • Arvind Suresh and
  • Gregory J. Tsongalis
  • + 10 authors

19 August 2024

Nearly all cervical cancers are caused by persistent high-risk human papillomavirus (hrHPV) infection. There are 14 recognized hrHPV genotypes (HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68), and hrHPV genotypes 16 and 18 comprise ap...

  • Communication
  • Open Access
1 Citations
2,414 Views
7 Pages

The Feasibility of Prenatal Ultrasonic Screening for Developmental Dysplasia of the Hip

  • Claudia Bevilacqua,
  • Virginia Boscarato,
  • Giovanni Pieroni,
  • Eva Fraternali,
  • Giuliano Lattanzi,
  • Simone Domenico Aspriello,
  • Antonio Pompilio Gigante and
  • Alessandro Cecchi

17 August 2024

Background: developmental dysplasia of the hip (DDH) is a condition characterized by abnormal hip development in infancy. Early diagnosis allows for effective treatment, while late presentation often necessitates complex surgical interventions. Curre...

  • Systematic Review
  • Open Access
2,330 Views
12 Pages

Association between Glycosylated Hemoglobin Levels and Vaccine Preventable Diseases: A Systematic Review

  • Elda De Vita,
  • Federica Limongi,
  • Nicola Veronese,
  • Francesco Di Gennaro,
  • Annalisa Saracino and
  • Stefania Maggi

17 August 2024

People with diabetes are at higher risk of serious complications from many vaccine-preventable diseases (VPDs). Some studies have highlighted the potential impact of glycosylated hemoglobin levels (HbA1c), but no systematic review has synthesized the...

  • Article
  • Open Access
10 Citations
10,123 Views
15 Pages

Therapeutic Effects of Semaglutide on Nonalcoholic Fatty Liver Disease with Type 2 Diabetes Mellitus and Obesity: An Open-Label Controlled Trial

  • Ahmed I. Gad,
  • Nevin F. Ibrahim,
  • Noura Almadani,
  • Rasha Mahfouz,
  • Hanaa A. Nofal,
  • Dina S. El-Rafey,
  • Hossam Tharwat Ali,
  • Amr T. EL-Hawary and
  • Ayman M. E. M. Sadek

17 August 2024

Background: GLP-1 receptor agonists (GLP-1 RAs) have been shown to improve glycemic control and insulin sensitivity and reduce body weight in obese patients with type 2 diabetes mellitus (T2D). This trial sought to evaluate the therapeutic effect of...

  • Article
  • Open Access
16 Citations
4,740 Views
14 Pages

AI-Driven Patient Education in Chronic Kidney Disease: Evaluating Chatbot Responses against Clinical Guidelines

  • Prakrati C. Acharya,
  • Raul Alba,
  • Pajaree Krisanapan,
  • Chirag M. Acharya,
  • Supawadee Suppadungsuk,
  • Eva Csongradi,
  • Michael A. Mao,
  • Iasmina M. Craici,
  • Jing Miao and
  • Wisit Cheungpasitporn
  • + 1 author

16 August 2024

Chronic kidney disease (CKD) patients can benefit from personalized education on lifestyle and nutrition management strategies to enhance healthcare outcomes. The potential use of chatbots, introduced in 2022, as a tool for educating CKD patients has...

  • Article
  • Open Access
63 Citations
3,080 Views
14 Pages

Indole-3 Carbinol and Diindolylmethane Mitigated β-Amyloid-Induced Neurotoxicity and Acetylcholinesterase Enzyme Activity: In Silico, In Vitro, and Network Pharmacology Study

  • Kakarla Ramakrishna,
  • Praditha Karuturi,
  • Queen Siakabinga,
  • Gajendra T.A.,
  • Sairam Krishnamurthy,
  • Shreya Singh,
  • Sonia Kumari,
  • G. Siva Kumar,
  • M. Elizabeth Sobhia and
  • Sachchida Nand Rai

16 August 2024

Background: Alzheimer’s disease (AD) is a neurodegenerative disease characterized by beta-amyloid (Aβ) deposition and increased acetylcholinesterase (AchE) enzyme activities. Indole 3 carbinol (I3C) and diindolylmethane (DIM) are reported...

  • Article
  • Open Access
3 Citations
2,653 Views
17 Pages

Influenza Vaccination of Nursing Students: A Cross-Sectional Study of Uptake, Knowledge, Attitudes, and Practices in Greece

  • Anastasia Statiri,
  • Theodoula Adamakidou,
  • Nikoletta Margari,
  • Ourania Govina,
  • Chrysoula Tsiou,
  • Konstantinos Giakoumidakis and
  • Eleni Dokoutsidou

14 August 2024

Influenza immunization includes a yearly repeated vaccine offered to every healthcare worker, including nursing students, with a high risk of contracting this viral disease. This study aimed to investigate the vaccination coverage, knowledge, attitud...

  • Protocol
  • Open Access
1 Citations
1,777 Views
9 Pages

12 August 2024

EUS–TA in unresectable pancreatic cancer requires not only a tissue diagnosis but also tissue collection in anticipation of comprehensive genomic profiling. However, the optimal puncture target remains controversial. Therefore, the Primary and...

  • Case Report
  • Open Access
3 Citations
3,365 Views
10 Pages

Pulmonary Benign Metastasizing Leiomyoma in a Postmenopausal Woman: A Case Report and Review of the Literature

  • Aleksandra Piórek,
  • Adam Płużański,
  • Piotr Wiśniewski,
  • Sylwia Tabor,
  • Kinga Winiarczyk,
  • Magdalena Knetki-Wróblewska,
  • Dariusz M. Kowalski and
  • Maciej Krzakowski

11 August 2024

Pulmonary benign metastasizing leiomyoma (PBML) is a rare condition characterized by the spread of uterine leiomyomas to the lungs, typically observed in premenopausal women with a history of hysterectomy or myomectomy. This report presents a unique...

  • Article
  • Open Access
10 Citations
4,560 Views
11 Pages

Practice Recommendations for the Management of MASLD in Primary Care: Consensus Results

  • Christos Lionis,
  • Sophia Papadakis,
  • Marilena Anastasaki,
  • Eftihis Aligizakis,
  • Foteini Anastasiou,
  • Sven Francque,
  • Irini Gergianaki,
  • Juan Manuel Mendive,
  • Maria Marketou and
  • Ioanna Tsiligianni
  • + 5 authors

10 August 2024

Background: Despite its high prevalence and impact on health, metabolic dysfunction-associated steatotic liver disease (MASLD) is inadequately addressed in European primary care (PC), with a large proportion of cases going undiagnosed or diagnosed to...

  • Review
  • Open Access
8 Citations
4,316 Views
13 Pages

Impact of Helicobacter pylori Eradication on Inflammatory Bowel Disease Onset and Disease Activity: To Eradicate or Not to Eradicate?

  • Antonietta Gerarda Gravina,
  • Raffaele Pellegrino,
  • Veronica Iascone,
  • Giovanna Palladino,
  • Alessandro Federico and
  • Rocco Maurizio Zagari

8 August 2024

Helicobacter pylori infection has significant epidemiological relevance due to the carcinogenic nature of this bacterium, which is potentially associated with cancer. When detected, it should ideally be eradicated using a treatment that currently inv...

  • Article
  • Open Access
6 Citations
3,686 Views
15 Pages

Unveiling the Immunostimulatory Potential of Rhus Toxicodendron in Immunocompromised Balb/C Mice Induced with Cyclophosphamide

  • Vara Prasad Saka,
  • Narasimha Kumar G. V.,
  • Bharat Kumar Reddy Sanapalli,
  • Abanti Goswami,
  • Anirban Roy,
  • Anurag Agrawal,
  • Pankaj Gupta,
  • Digvijay Verma and
  • Subhash Kaushik

8 August 2024

This study investigated how Rhus toxicodendron (RT) (6C, 30C, and 200C) can boost the immune system of BALB/c mice that were given cyclophosphamide (CPM), which is an anticancer drug that weakens the immune system. RT, known for its historical use in...

  • Systematic Review
  • Open Access
2 Citations
2,896 Views
24 Pages

Unveiling TIMPs: A Systematic Review of Their Role as Biomarkers in Atherosclerosis and Coronary Artery Disease

  • Amilia Aminuddin,
  • Nazirah Samah,
  • Ubashini Vijakumaran,
  • Nur Aishah Che Roos,
  • Faridah Mohd Nor,
  • Wan Mohammad Hafiz Wan Razali,
  • Shawal Faizal Mohamad,
  • Beh Boon Cong,
  • Faizal Amri Hamzah and
  • Azizah Ugusman
  • + 1 author

2 August 2024

Coronary artery disease (CAD) is the leading cause of death globally and is a heart condition involving insufficient blood supply to the heart muscle due to atherosclerotic plaque formation. Atherosclerosis is a chronic disease in which plaques, made...

  • Review
  • Open Access
19 Citations
6,130 Views
23 Pages

Exploring the Exposome Spectrum: Unveiling Endogenous and Exogenous Factors in Non-Communicable Chronic Diseases

  • Laura Di Renzo,
  • Paola Gualtieri,
  • Giulia Frank,
  • Rossella Cianci,
  • Mario Caldarelli,
  • Giulia Leggeri,
  • Glauco Raffaelli,
  • Erica Pizzocaro,
  • Michela Cirillo and
  • Antonino De Lorenzo

2 August 2024

The exposome encompasses all endogenous and exogenous exposure individuals encounter throughout their lives, including biological, chemical, physical, psychological, relational, and socioeconomic factors. It examines the duration and intensity of the...

  • Article
  • Open Access
3 Citations
2,321 Views
12 Pages

Treating Aortic Valve Stenosis for Vitality Improvement: The TAVI Study

  • Donato Tartaglione,
  • Dario Prozzo,
  • Renatomaria Bianchi,
  • Giovanni Ciccarelli,
  • Maurizio Cappelli Bigazzi,
  • Francesco Natale,
  • Paolo Golino and
  • Giovanni Cimmino

2 August 2024

Background: Degenerative aortic valve stenosis (AS) is the most common valvular heart disease among the elderly. Once cardiac symptoms occur, current guidelines recommend aortic valve replacement. Progressive degeneration/calcification reduces leafle...

  • Article
  • Open Access
2 Citations
4,419 Views
10 Pages

Evaluation of the Effectiveness of Combined Treatment with Intravaginal Diazepam and Pelvic Floor Rehabilitation in Patients with Vulvodynia by Ultrasound Monitoring of Biometric Parameters of Pelvic Muscles: A Pilot Study

  • Lucia Merlino,
  • Enrico Ciminello,
  • Agnese Immacolata Volpicelli,
  • Stefano Tillier,
  • Marianna Francesca Pasquali,
  • Mattia Dominoni,
  • Barbara Gardella,
  • Roberto Senatori,
  • Barbara Dionisi and
  • Maria Grazia Piccioni

1 August 2024

(1) Background: Vulvodynia is characterized by vulvar pain for at least three months and may have related variables, one of these being pelvic floor hypertonus. The purpose of this study was to compare the therapeutic effectiveness of two weekly sess...

  • Systematic Review
  • Open Access
15 Citations
6,852 Views
13 Pages

Impact of School Nurse on Managing Pediatric Type 1 Diabetes with Technological Devices Support: A Systematic Review

  • Giovanni Cangelosi,
  • Stefano Mancin,
  • Sara Morales Palomares,
  • Paola Pantanetti,
  • Elisabetta Quinzi,
  • Giulia Debernardi and
  • Fabio Petrelli

1 August 2024

Introduction: Type 1 diabetes (T1D) is a disease that primarily occurs in pediatric populations. A school nurse (SN) can provide valuable support in the school setting for minors affected by this condition. Methods: The main objective of this study w...

  • Hypothesis
  • Open Access
2 Citations
2,294 Views
14 Pages

Unveiling the Unexplored Multifactorial Potential of 5-Aminosalicylic Acid in Diabetic Wound Therapy

  • Bharat Kumar Reddy Sanapalli,
  • Ashwini Deshpande,
  • Vidyasrilekha Sanapalli and
  • Dilep Kumar Sigalapalli

1 August 2024

Diabetic wounds (DWs) are considered chronic complications observed in patients suffering from type 2 diabetes mellitus (DM). Usually, DWs originate from the interplay of inflammation, oxidation, impaired tissue re-epithelialization, vasculopathy, ne...

  • Article
  • Open Access
3,895 Views
13 Pages

Evaluating Immunologic and Illness Outcomes of SARS-CoV-2 Infection in Vaccinated and Unvaccinated Children Aged ≥ 5 Years, in a Multisite Longitudinal Cohort

  • Cynthia Porter,
  • Zoe L. Lyski,
  • Jennifer L. Uhrlaub,
  • Katherine D. Ellingson,
  • Zuha Jeddy,
  • Lisa Gwynn,
  • Patrick Rivers,
  • Ryan Sprissler,
  • Kurt T. Hegmann and
  • Karen Lutrick
  • + 23 authors

1 August 2024

Hybrid immunity, as a result of infection and vaccination to SARS-CoV-2, has been well studied in adults but limited evidence is available in children. We evaluated the antibody responses to primary SARS-CoV-2 infection among vaccinated and unvaccina...

  • Article
  • Open Access
1 Citations
1,477 Views
10 Pages

1 August 2024

There is little published research on limited physical functioning in United States (US) adults with arthritis. The objective of this cross-sectional 2021 Medical Expenditure Panel Survey (MEPS) database study was to investigate the variables associa...

  • Article
  • Open Access
2 Citations
1,507 Views
10 Pages

Could Ocular Glands Be Infected by SARS-CoV-2?

  • Jinghua Bu,
  • Minjie Zhang,
  • Rongrong Zhang,
  • Le Sun,
  • Zhenzong Chen and
  • Yang Wu

25 July 2024

The aim of the study was to investigate the expression levels of ACE2 in ocular glands and to investigate the effect of S protein on them. Male C57BL/6J mice were used for the experiments. The expression levels of ACE2 are highest in the Meibomian gl...

  • Article
  • Open Access
6 Citations
4,342 Views
14 Pages

Sudden Cardiac Death-Etiology, Risk Factors and Demographic Characteristics: An Extensive Study of 1618 Forensic Autopsies

  • Ioana Radu,
  • Anca Otilia Farcas,
  • Victoria Nyulas,
  • Carmen Corina Radu and
  • Klara Brinzaniuc

25 July 2024

Background: Sudden cardiac death (SCD) is a major public health concern worldwide, affecting all age and social groups. Methods: In this retrospective study, of the 8265 autopsies performed in the Institute of Legal Medicine, 1618 cases of SCD were i...

  • Case Report
  • Open Access
1 Citations
3,723 Views
9 Pages

Paediatric Calcaneal Osteochondroma: A Case Report and a Literature Review

  • Valeria Calogero,
  • Michela Florio,
  • Silvia Careri,
  • Angelo Gabriele Aulisa,
  • Francesco Falciglia and
  • Marco Giordano

25 July 2024

Background: Heel pain in children is a common condition. The aetiology can be ascribed to fractures, osteochondrosis, tendinitis, calcaneal-navicular or talo-calcaneal coalition, osteomyelitis, rheumatic diseases, anatomic variants, malignant tumours...

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Diseases - ISSN 2079-9721