Pulmonary Benign Metastasizing Leiomyoma in a Postmenopausal Woman: A Case Report and Review of the Literature
Abstract
1. Introduction
2. Case Report
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Criterion | PBML | LMS |
---|---|---|
Clinical Presentation | Asymptomatic, rarely respiratory symptoms. In aggressive cases: significant respiratory distress, increased nodule size, systemic symptoms (weight loss, fatigue) | Severe and acute symptoms such as cough, hemoptysis, chest pain, rapid deterioration in respiratory function |
Radiological Features | Multiple, well-circumscribed nodules. In aggressive cases: diffuse miliary patterns, cavitated nodule | Irregular, invasive masses, single or multiple nodules, often showing aggressive invasion into surrounding tissues |
Histopathological Features | Spindle cells, no atypia, low mitotic index. Aggressive PBML may show higher proliferative activity | Spindle cells with significant atypia, high mitotic index, areas of necrosis |
Immunohistochemistry | Desmin(+), SMA(+), ER/PR(+) | Desmin(+), SMA(+), sometimes ER/PR(−) |
Hormone Receptor Expression | Often present (ER, PR) | Less commonly present |
Clinical Behavior | Slow-growing, rarely aggressive. Aggressive cases show rapid growth and severe symptoms | Aggressive, rapid growth |
Treatment | Hysterectomy, oophorectomy, hormonal therapy. Aggressive cases may require more intensive treatment | Surgery, radiotherapy, chemotherapy |
Prognosis | Good, dependent on hormonal therapy. Variable in aggressive cases | Variable, often poor |
Authors | Year | Journal | Key Findings |
---|---|---|---|
Ventura L et al. | 2021 | Molecular Biology Reports [54] | Role of miRNA-221 and miRNA-126 in PBML, offering new diagnostic, prognostic, and therapeutic perspectives. |
Tamura S et al. | 2022 | J Clin Med Res [55] | Identified potential biomarkers related to the pathogenesis of uterine benign mesenchymal tumors and PBML. |
Zhang G et al. | 2024 | BMC Medicine [56] | Sirolimus is safe and effective in treating PBML. |
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Piórek, A.; Płużański, A.; Wiśniewski, P.; Tabor, S.; Winiarczyk, K.; Knetki-Wróblewska, M.; Kowalski, D.M.; Krzakowski, M. Pulmonary Benign Metastasizing Leiomyoma in a Postmenopausal Woman: A Case Report and Review of the Literature. Diseases 2024, 12, 181. https://doi.org/10.3390/diseases12080181
Piórek A, Płużański A, Wiśniewski P, Tabor S, Winiarczyk K, Knetki-Wróblewska M, Kowalski DM, Krzakowski M. Pulmonary Benign Metastasizing Leiomyoma in a Postmenopausal Woman: A Case Report and Review of the Literature. Diseases. 2024; 12(8):181. https://doi.org/10.3390/diseases12080181
Chicago/Turabian StylePiórek, Aleksandra, Adam Płużański, Piotr Wiśniewski, Sylwia Tabor, Kinga Winiarczyk, Magdalena Knetki-Wróblewska, Dariusz M. Kowalski, and Maciej Krzakowski. 2024. "Pulmonary Benign Metastasizing Leiomyoma in a Postmenopausal Woman: A Case Report and Review of the Literature" Diseases 12, no. 8: 181. https://doi.org/10.3390/diseases12080181
APA StylePiórek, A., Płużański, A., Wiśniewski, P., Tabor, S., Winiarczyk, K., Knetki-Wróblewska, M., Kowalski, D. M., & Krzakowski, M. (2024). Pulmonary Benign Metastasizing Leiomyoma in a Postmenopausal Woman: A Case Report and Review of the Literature. Diseases, 12(8), 181. https://doi.org/10.3390/diseases12080181