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Antibiotics, Volume 11, Issue 12

December 2022 - 171 articles

Cover Story: Antimicrobial resistance (AMR) is the ability of microorganisms to become increasingly resistant to an antimicrobial to which they were previously susceptible. Overuse and misuse of antimicrobials in both human and animal medicine has accelerated the process of the emergence and spread of antimicrobial resistant bacteria. The AMR crisis among clinically important pathogens, together with the lack of therapeutic drugs, supports the idea that new strategies with novel mechanisms of action are needed. In this sense, metal-based drugs may be an important source of research. In this paper, the efficacy of gold(III) complexes as antibacterial and antibiofilm agents is studied against pathogenic bacteria of veterinary origin. View this paper
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Articles (171)

  • Brief Report
  • Open Access
3 Citations
3,439 Views
8 Pages

Genomic Analysis of Klebsiella pneumoniae ST258 Strain Coproducing KPC-2 and CTX-M-14 Isolated from Poultry in the Brazilian Amazon Region

  • Tiago Barcelos Valiatti,
  • Rodrigo Cayô,
  • Fernanda Fernandes Santos,
  • Francisco Ozório Bessa-Neto,
  • Ramon Giovani Brandão Silva,
  • Ruanita Veiga,
  • Márcia de Nazaré Miranda Bahia,
  • Lívia Maria Guimarães Dutra Guerra,
  • Antônio Carlos Campos Pignatari and
  • Cintya de Oliveira Souza
  • + 2 authors

17 December 2022

This study aimed to characterize a Klebsiella pneumoniae strain (KP411) recovered from the stool samples of poultry (Gallus gallus) in the Brazilian Amazon Region. The whole-genome sequencing of KP411 revealed the presence of an important arsenal of...

  • Article
  • Open Access
8 Citations
2,439 Views
13 Pages

Oligopeptide Sortase Inhibitor Modulates Staphylococcus aureus Cell Adhesion and Biofilm Formation

  • Svetlana A. Bozhkova,
  • Ekaterina M. Gordina,
  • Dmitry V. Labutin and
  • Konstantin V. Kudryavtsev

17 December 2022

Prevention of bacterial adhesion is one of the most important antivirulence strategies for meeting the global challenge posed by antimicrobial resistance. We aimed to investigate the influence of a peptidic S. aureus sortase A inhibitor on bacterial...

  • Article
  • Open Access
9 Citations
3,057 Views
24 Pages

The Anti-Virulence Effect of Vismia guianensis against Candida albicans and Candida glabrata

  • Elizangela Pestana Motta,
  • Josivan Regis Farias,
  • Arthur André Castro da Costa,
  • Anderson França da Silva,
  • Alberto Jorge Oliveira Lopes,
  • Maria do Socorro Sousa Cartágenes,
  • Roberto Nicolete,
  • Afonso Gomes Abreu,
  • Elizabeth Soares Fernandes and
  • Flavia Raquel Fernandes Nascimento
  • + 3 authors

16 December 2022

In folk medicine, Vismia guianensis is used to treat skin diseases and mycoses in the Amazon region. We evaluated the anti-Candida activity of the hydroalcoholic extract from the leaves of Vismia guianensis (EHVG). HPLC-PDA and FIA-ESI-IT-MSn were us...

  • Article
  • Open Access
2 Citations
2,643 Views
22 Pages

Use of Antimicrobials by Class in Pigs in Germany—A Longitudinal Description Considering Different International Categorisation Systems

  • Clarissa Bonzelett,
  • Anne Schnepf,
  • Maria Hartmann,
  • Annemarie Käsbohrer and
  • Lothar Kreienbrock

16 December 2022

Antimicrobial usage in both human and veterinary medicine is considered one of the main drivers of antimicrobial resistance; its reduction poses a serious challenge. To analyse the associations between usage and resistance, data from monitoring syste...

  • Article
  • Open Access
6 Citations
2,678 Views
27 Pages

Optimization of Pyrazole Compounds as Antibiotic Adjuvants Active against Colistin- and Carbapenem-Resistant Acinetobacter baumannii

  • Filomena Sannio,
  • Antonella Brizzi,
  • Rosita Del Prete,
  • Marialuce Avigliano,
  • Tiziana Simone,
  • Carlotta Pagli,
  • Teresa Ferraro,
  • Filomena De Luca,
  • Marco Paolino and
  • Federico Corelli
  • + 2 authors

16 December 2022

The diffusion of antibiotic-resistant, Gram-negative, opportunistic pathogens, an increasingly important global public health issue, causes a significant socioeconomic burden. Acinetobacter baumannii isolates, despite causing a lower number of infect...

  • Article
  • Open Access
1 Citations
2,496 Views
12 Pages

Staphylococcus aureus-Cure-Associated Antigens Elicit Type 3 Immune Memory T Cells

  • Kamila R. Santos,
  • Fernando N. Souza,
  • Eduardo M. Ramos-Sanchez,
  • Camila F. Batista,
  • Luiza C. Reis,
  • Wesley L. Fotoran,
  • Marcos B. Heinemann,
  • Adriano F. Cunha,
  • Mussya C. Rocha and
  • Angélica R. Faria
  • + 5 authors

16 December 2022

Background: Staphylococcus aureus is one of the most frequently major mastitis pathogens that cause clinical and subclinical mastitis worldwide. Current antimicrobial treatments are usually ineffective, and the commercially available vaccines lack pr...

  • Review
  • Open Access
92 Citations
12,053 Views
31 Pages

Alternatives Therapeutic Approaches to Conventional Antibiotics: Advantages, Limitations and Potential Application in Medicine

  • Hiba Alaoui Mdarhri,
  • Rachid Benmessaoud,
  • Houda Yacoubi,
  • Lina Seffar,
  • Houda Guennouni Assimi,
  • Mouhsine Hamam,
  • Rihabe Boussettine,
  • Najoie Filali-Ansari,
  • Fatima Azzahra Lahlou and
  • Idrissa Diawara
  • + 2 authors

16 December 2022

Resistance to antimicrobials and particularly multidrug resistance is one of the greatest challenges in the health system nowadays. The continual increase in the rates of antimicrobial resistance worldwide boosted by the ongoing COVID-19 pandemic pos...

  • Article
  • Open Access
8 Citations
3,747 Views
23 Pages

16 December 2022

Twenty samples of minced chicken meat procured from butcher’s shops in León (Spain; 10 samples) and Vila Real (Portugal; 10 samples) were analyzed. Microbial concentrations (log10 cfu/g) of 7.53 ± 1.02 (viable aerobic microbiota),...

  • Article
  • Open Access
6 Citations
3,189 Views
14 Pages

E-Learning versus Face-to-Face Methodology for Learning Antimicrobial Resistance and Prescription Practice in a Tertiary Hospital of a Middle-Income Country

  • Paulina Isabel Armas Freire,
  • Gilberto Gambero Gaspar,
  • Jeannete Zurita,
  • Grace Salazar,
  • Jorge Washington Velez and
  • Valdes Roberto Bollela

16 December 2022

Background: Antimicrobial resistance is a growing health problem worldwide. One strategy to face this problem in a reasonable way is training health personnel for the rational use of antimicrobials. There are some difficulties associated with medical...

  • Article
  • Open Access
9 Citations
4,884 Views
10 Pages

Pharmacokinetic of Cefiderocol in Critically Ill Patients Receiving Renal Replacement Therapy: A Case Series

  • Simone Mornese Pinna,
  • Silvia Corcione,
  • Amedeo De Nicolò,
  • Giorgia Montrucchio,
  • Silvia Scabini,
  • Davide Vita,
  • Ilaria De Benedetto,
  • Tommaso Lupia,
  • Jacopo Mula and
  • Giovanni Di Perri
  • + 2 authors

16 December 2022

Background: Cefiderocol is a novel parenteral siderophore cephalosporin, demonstrating enhanced activity against multidrug-resistant (MDR) Gram-negative bacteria and difficult-to-treat Acinetobacter baumannii (DTR-AB). Plasma-free trough concentratio...

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Antibiotics - ISSN 2079-6382