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Antibiotics, Volume 10, Issue 8

August 2021 - 142 articles

Cover Story: Treatment of infections by the sexually transmitted pathogen Mycoplasma genitalium is hampered by the rapidly increasing resistance to the recommended antibiotics. Thus, resistance-guided therapy (RGT) is key for successful eradication. In this context, typing of strains is helpful to distinguish between ongoing colonization, re-infection, or development of resistance. MgpB and MG_309 types, as well as mutations associated with macrolide, quinolone, and tetracycline resistance of strains in M. genitalium-positive samples accumulated at a university hospital were analyzed. Twenty-three mgpB types, nine MG_309 types and 34 mgpB/MG_309 types were identified. The prevalence of mutations associated with macrolide, quinolone, and tetracycline resistance was 56.9%, 10.3%, and 6.8%, respectively. The rate of successful eradication (93.3%) is promising for continuation of the RGT strategy. View this paper.
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Articles (142)

  • Article
  • Open Access
18 Citations
4,154 Views
15 Pages

Climatic Alterations Influence Bacterial Growth, Biofilm Production and Antimicrobial Resistance Profiles in Aeromonas spp.

  • Miguel L. Grilo,
  • Ana Pereira,
  • Carla Sousa-Santos,
  • Joana I. Robalo and
  • Manuela Oliveira

Climate change is expected to create environmental disruptions that will impact a wide array of biota. Projections for freshwater ecosystems include severe alterations with gradients across geographical areas. Life traits in bacteria are modulated by...

  • Article
  • Open Access
16 Citations
3,764 Views
13 Pages

The Antimicrobial Activity of Omiganan Alone and In Combination against Candida Isolated from Vulvovaginal Candidiasis and Bloodstream Infections

  • Dawid Żyrek,
  • Andrzej Wajda,
  • Paulina Czechowicz,
  • Joanna Nowicka,
  • Maciej Jaśkiewicz,
  • Damian Neubauer and
  • Wojciech Kamysz

Fungi from the Candida genus are widespread commensals and, at the same time, are the leading cause of fungal infections worldwide. For instance, vulvovaginal candidiasis (VVC) affects approximately 75% of women at least once in their lifetime, remai...

  • Review
  • Open Access
82 Citations
10,201 Views
29 Pages

The synthesis of new compounds with antimicrobial and antiviral properties is a central objective today in the context of the COVID-19 pandemic. Benzimidazole and pyrazole compounds have remarkable biological properties, such as antimicrobial, antivi...

  • Article
  • Open Access
17 Citations
3,923 Views
11 Pages

Peroxynitrous Acid Generated In Situ from Acidified H2O2 and NaNO2. A Suitable Novel Antimicrobial Agent?

  • Martina Balazinski,
  • Ansgar Schmidt-Bleker,
  • Jörn Winter and
  • Thomas von Woedtke

Peroxynitrite (ONOO−) and peroxynitrous acid (ONOOH) are known as short acting reactive species with nitrating and oxidative properties, which are associated with their antimicrobial effect. However, to the best of our knowledge, ONOOH/ONOO- are not...

  • Article
  • Open Access
6 Citations
4,023 Views
14 Pages

The Prevalence and Factors Associated with Prophylactic Antibiotic Use during Delivery: A Hospital-Based Retrospective Study in Palembang, Indonesia

  • Ariesti Karmila,
  • Mohammad Zulkarnain,
  • Abarham Martadiansyah,
  • Putri Mirani,
  • Nuswil Bernolian,
  • Joseph C. Gardiner and
  • Lixin Zhang

Prophylactic antibiotic usage during delivery is a common practice worldwide, especially in low- to middle-income countries. Guidelines have been published to reduce antibiotic overuse; however, data describing the use of prophylactic antibiotics and...

  • Article
  • Open Access
25 Citations
3,887 Views
19 Pages

Computational Drug Repurposing for Antituberculosis Therapy: Discovery of Multi-Strain Inhibitors

  • Valeria V. Kleandrova,
  • Marcus T. Scotti and
  • Alejandro Speck-Planche

Tuberculosis remains the most afflicting infectious disease known by humankind, with one quarter of the population estimated to have it in the latent state. Discovering antituberculosis drugs is a challenging, complex, expensive, and time-consuming t...

  • Article
  • Open Access
15 Citations
5,205 Views
17 Pages

Evidence-Based Tracking of MDR E. coli from Bovine Endometritis and Its Elimination by Effective Novel Therapeutics

  • Laiba Shafique,
  • Siwen Wu,
  • Amjad Islam Aqib,
  • Muhammad Muddassir Ali,
  • Misbah Ijaz,
  • Muhammad Aamir Naseer,
  • Zaeem Sarwar,
  • Rais Ahmed,
  • Arslan Saleem and
  • Qudratullah
  • + 3 authors

Antibiotic-resistant bacteria have become the predominant etiology of endometritis and thus require effective treatment approaches. We used ultrasonography coupled with clinical signs and presented complaints of reproductive issues to investigate the...

  • Article
  • Open Access
2 Citations
4,436 Views
12 Pages

Microbiological Characteristics and Surgical Management of Animal-Bite-Related Oral & Maxillofacial Injuries: A Single Center’s Experience

  • Johannes Spille,
  • Juliane Schulz,
  • Dorothee Cäcilia Spille,
  • Hendrik Naujokat,
  • Henning Wieker,
  • Jörg Wiltfang and
  • Aydin Gülses

The objective of the current study is to retrospectively evaluate animal-bite injuries and to gain insight into the epidemiology, accident consequences and treatment concept of these accidents in oral and maxillofacial surgery. Data of patients, who...

  • Review
  • Open Access
33 Citations
11,361 Views
13 Pages

Bacteriophage Technology and Modern Medicine

  • Aa Haeruman Azam,
  • Xin-Ee Tan,
  • Srivani Veeranarayanan,
  • Kotaro Kiga and
  • Longzhu Cui

The bacteriophage (or phage for short) has been used as an antibacterial agent for over a century but was abandoned in most countries after the discovery and broad use of antibiotics. The worldwide emergence and high prevalence of antimicrobial-resis...

  • Review
  • Open Access
12 Citations
14,484 Views
15 Pages

Gram-Positive Pneumonia: Possibilities Offered by Phage Therapy

  • Lucía Fernández,
  • María Dolores Cima-Cabal,
  • Ana Catarina Duarte,
  • Ana Rodríguez,
  • María del Mar García-Suárez and
  • Pilar García

Pneumonia is an acute pulmonary infection whose high hospitalization and mortality rates can, on occasion, bring healthcare systems to the brink of collapse. Both viral and bacterial pneumonia are uncovering many gaps in our understanding of host–pat...

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Antibiotics - ISSN 2079-6382