Nanomaterials, Volume 12, Issue 21
2022 November-1 - 214 articles
Cover Story: Two strategies were combined to develop chemotherapeutics with higher activity and reduced toxicity. Multifunctional platinum(IV) complexes exhibiting higher stability compared to their platinum(II) counterparts were prepared and loaded into mesoporous silica SBA-15. The mesoporous silica nanoparticles, employed to enable targeted drug delivery through the enhanced permeability and retention effect, demonstrated excellent potential to provide the slow release of active complexes, ensuring prolonged exposure at the tumor site. The excellent in vitro cytotoxicity of these drugs, which are superior to cisplatin, was demonstrated against different breast cancer cell lines. In vivo, tumor growth inhibition without nephrotoxicity was achieved. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
- You may sign up for email alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.