Dear Colleagues,

Human and environmental exposure to nanomaterials has become an unavoidable reality. The expansion of nanotechnology has brought products of daily application to the market which use nanoparticles as functional or supporting materials. Understanding the interactions of nanomaterials with biological systems is crucial to anticipate biological risks and to establish criteria for designing as-safe-as-possible nanomaterials and nano-enabled products.

After decades of research, some aspects that lead to the adverse interaction of nanomaterials with biological systems have been identified; this knowledge provides the basis for conceptual frameworks to assess and manage the risk stemming from the use of nanomaterials. As often in science, improved knowledge around nano-safety has opened new questions arising from still unresolved uncertainties: the physicochemical heterogeneity of nanoparticles does not allow to generalize conclusions; the details of the interaction of nanomaterials with cells and organisms are largely unknown; the transformations of nanoparticles moving through different biological compartments makes it extremely difficult to establish safe amounts. As of today, these uncertainties still prevent the adoption of effective regulatory and protective rules. With the ambition to mark a further step towards safe nanotechnology, which is a multi-faceted objective, this Special Issue collates a series of original articles focusing on new findings in nanotoxicology, theoretical and experimental methods for understanding the interaction of nanoparticles with biological systems, statistical methods to estimate risks, and strategies for mitigating risks of hazardous nanoparticles.

Dr. Felice C. Simeone
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• physicochemical drivers of hazard
• mechanisms of hazard
• adverse outcome pathways
• modelling of risk
• nanotoxicology
• dosimetry
• risk assessment
• change grouping strategies
• safety-by-design