Special Issue "Towards a Safe Nanotechnology: Understanding and Controlling Immunomodulatory and Toxicological Properties of Nanomaterials"

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 20 September 2023 | Viewed by 1380

Special Issue Editor

National Research Council Italy - CNR, Institute of Science and Technology for Ceramics - ISTEC, Via Granarolo 64, I-48018 Faenza, RA, Italy
Interests: nanoscience; Bayesian risk assessment; biomimetic membranes; nano-electrochemistry

Special Issue Information

Dear Colleagues,

Human and environmental exposure to nanomaterials has become an unavoidable reality. The expansion of nanotechnology has brought products of daily application to the market which use nanoparticles as functional or supporting materials. Understanding the interactions of nanomaterials with biological systems is crucial to anticipate biological risks and to establish criteria for designing as-safe-as-possible nanomaterials and nano-enabled products.

After decades of research, some aspects that lead to the adverse interaction of nanomaterials with biological systems have been identified; this knowledge provides the basis for conceptual frameworks to assess and manage the risk stemming from the use of nanomaterials. As often in science, improved knowledge around nano-safety has opened new questions arising from still unresolved uncertainties: the physicochemical heterogeneity of nanoparticles does not allow to generalize conclusions; the details of the interaction of nanomaterials with cells and organisms are largely unknown; the transformations of nanoparticles moving through different biological compartments makes it extremely difficult to establish safe amounts. As of today, these uncertainties still prevent the adoption of effective regulatory and protective rules. With the ambition to mark a further step towards safe nanotechnology, which is a multi-faceted objective, this Special Issue collates a series of original articles focusing on new findings in nanotoxicology, theoretical and experimental methods for understanding the interaction of nanoparticles with biological systems, statistical methods to estimate risks, and strategies for mitigating risks of hazardous nanoparticles.

Dr. Felice C. Simeone
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • physicochemical drivers of hazard
  • mechanisms of hazard
  • adverse outcome pathways
  • modelling of risk
  • nanotoxicology
  • dosimetry
  • risk assessment
  • change grouping strategies
  • safety-by-design

Published Papers (1 paper)

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Review

Review
Diverse Pathways of Engineered Nanoparticle-Induced NLRP3 Inflammasome Activation
Nanomaterials 2022, 12(21), 3908; https://doi.org/10.3390/nano12213908 - 05 Nov 2022
Viewed by 1035
Abstract
With the rapid development of engineered nanomaterials (ENMs) in biomedical applications, their biocompatibility and cytotoxicity need to be evaluated properly. Recently, it has been demonstrated that inflammasome activation may be a vital contributing factor for the development of biological responses induced by ENMs. [...] Read more.
With the rapid development of engineered nanomaterials (ENMs) in biomedical applications, their biocompatibility and cytotoxicity need to be evaluated properly. Recently, it has been demonstrated that inflammasome activation may be a vital contributing factor for the development of biological responses induced by ENMs. Among the inflammasome family, NLRP3 inflammasome has received the most attention because it directly interacts with ENMs to cause the inflammatory effects. However, the pathways that link ENMs to NLRP3 inflammasome have not been thoroughly summarized. Thus, we reviewed recent findings on the role of major ENMs properties in modulating NLRP3 inflammasome activation, both in vitro and in vivo, to provide a better understanding of the underlying mechanisms. In addition, the interactions between ENMs and NLRP3 inflammasome activation are summarized, which may advance our understanding of safer designs of nanomaterials and ENM-induced adverse health effects. Full article
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