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Nanomaterials
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Advancements of Nanomaterials in Oral Health and Clinical Dentistry
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Advancements of Nanomaterials in Oral Health and Clinical Dentistry

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 4740

Special Issue Editors

Dr. Zohaib Khurshid

E-Mail Website
Guest Editor
1. Department of Prosthodontics and Dental Implantology, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia
2. Center of Excellence for Regenerative Dentistry, Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand
Interests: dental biomaterials; oral tissue engineering; bone cements; bone implants; oral antimicrobial peptides; biosensors; oral fluids proteomics; implant dentistry; dental education; bioactive glasses; sustainability
Special Issues, Collections and Topics in MDPI journals
Dr. Amanda Maria De Oliveira Dal Piva

E-Mail Website
Guest Editor
Department of Dental Materials, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, 1081 LA Amsterdam, The Netherlands
Interests: prosthodontics; dental materials; biomaterials; mechanical properties; adhesive dentistry
Special Issues, Collections and Topics in MDPI journals
Dr. Jithendra Ratnayake

E-Mail Website
Guest Editor
Department of Oral Sciences, Faculty of Dentistry, The University of Otago, Dunedin 9016, New Zealand
Interests: biomaterials; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Muhammad Sohail Zafar

E-Mail Website1 Website2
Guest Editor
Department of Restorative Dentistry, College of Dentistry, Taibah University, Al Madina Al Munawara 41311, Saudi Arabia
Interests: dental biomaterials; natural polymers; molecular biology; electrospinning; oral tissue regeneration; nanotechnology; biomolecules; clinical dentistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue of Nanomaterials includes high-impact articles on advancements in nanomaterials and nanotechnology related to improving oral health and clinical dentistry. It covers novel nanomaterials’ synthesis, characterization and use in treatment strategies for overcoming dental hard- and soft-tissue disease. Nanotechnology helps in attaining a healthier lifestyle. Nanomaterials have been extensively explored in different fields of dentistry, e. g., preventive dentistry, operative dentistry, periodontology, stomatology, and implantology. Examples include accelerating bone healing by coating nanoparticles onto dental implants surfaces and oral drug delivery.

The main objective of this Special Issue is to publish original studies, systematic and metanalysis review papers and randomized clinical trials that have investigated the effect of using nanomaterials in diagnostic and therapeutic procedures in oral health and clinical dentistry.

This Special Issue will cover the following themes.

  • Nanoparticles.
  • Nanomaterials.
  • Zirconia nanoparticles.
  • Nano-adhesive.
  • Titanium nanoparticles.
  • Dental implants.
  • Prosthodontic materials.
  • Dental caries.
  • Preventive materials.
  • Dental composite.
  • Nanocomposites.
  • Dental ceramics.
  • Nano-drugs and delivery.
  • Antimicrobial drugs.
  • Regenerative dentistry.

Dr. Zohaib Khurshid
Dr. Amanda Maria De Oliveira Dal Piva
Dr. Jithendra Ratnayake
Prof. Dr. Muhammad Zafar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • nanomaterials
  • zirconia nanoparticles
  • nano-adhesive
  • titanium nanoparticles
  • dental implants
  • prosthodontic materials
  • dental caries
  • preventive materials
  • dental composite
  • nanocomposites
  • dental ceramics
  • nano-drugs and delivery
  • antimicrobial drugs
  • regenerative dentistry

Published Papers (4 papers)

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Research

9 pages, 960 KiB  
Article
Enhancement of Hydrophilicity of Nano-Pitted TiO2 Surface Using Phosphoric Acid Etching
by Ferenc Koppány, Krisztián Benedek Csomó, Edvárd Márton Varmuzsa, Eszter Bognár, Liza Pelyhe, Péter Nagy, Imre Kientzl, Dániel Szabó, Miklós Weszl, Gábor Dobos, Sándor Lenk, Gábor Erdei, Gábor Kiss, Lilien Nagy, Attila Sréter, Andrea Alexandra Belik, Zsuzsanna Tóth, János Vág, Árpád Joób-Fancsaly and Zsolt Németh
Nanomaterials 2023, 13(3), 511; https://doi.org/10.3390/nano13030511 - 27 Jan 2023
Cited by 2 | Viewed by 1366
Abstract
Our research group developed a novel nano-pitted (NP) TiO2 surface on grade 2 titanium that showed good mechanical, osteogenic, and antibacterial properties; however, it showed weak hydrophilicity. Our objective was to develop a surface treatment method to enhance the hydrophilicity of the [...] Read more.
Our research group developed a novel nano-pitted (NP) TiO2 surface on grade 2 titanium that showed good mechanical, osteogenic, and antibacterial properties; however, it showed weak hydrophilicity. Our objective was to develop a surface treatment method to enhance the hydrophilicity of the NP TiO2 surface without the destruction of the nano-topography. The effects of dilute and concentrated orthophosphoric (H3PO4) and nitric acids were investigated on wettability using contact angle measurement. Optical profilometry and atomic force microscopy were used for surface roughness measurement. The chemical composition of the TiO2 surface and the oxidation state of Ti was investigated using X-ray photoelectron spectroscopy. The ccH3PO4 treatment significantly increased the wettability of the NP TiO2 surfaces (30°) compared to the untreated control (88°). The quantity of the absorbed phosphorus significantly increased following ccH3PO4 treatment compared to the control and caused the oxidation state of titanium to decrease (Ti4+ → Ti3+). Owing to its simplicity and robustness the presented surface treatment method may be utilized in the industrial-scale manufacturing of titanium implants. Full article
(This article belongs to the Special Issue Advancements of Nanomaterials in Oral Health and Clinical Dentistry)
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16 pages, 29796 KiB  
Article
Laser-Induced µ-Rooms for Osteocytes on Implant Surface: An In Vivo Study
by Vadim Veiko, Yuliya Karlagina, Ekaterina Zernitckaia, Elena Egorova, Maxim Radaev, Andrey Yaremenko, Gennadiy Chernenko, Valery Romanov, Nadezhda Shchedrina, Elena Ivanova, Boris Chichkov and Galina Odintsova
Nanomaterials 2022, 12(23), 4229; https://doi.org/10.3390/nano12234229 - 28 Nov 2022
Cited by 4 | Viewed by 1594
Abstract
Laser processing of dental implant surfaces is becoming a more widespread replacement for classical techniques due to its undeniable advantages, including control of oxide formation and structure and surface relief at the microscale. Thus, using a laser, we created several biomimetic topographies of [...] Read more.
Laser processing of dental implant surfaces is becoming a more widespread replacement for classical techniques due to its undeniable advantages, including control of oxide formation and structure and surface relief at the microscale. Thus, using a laser, we created several biomimetic topographies of various shapes on the surface of titanium screw-shaped implants to research their success and survival rates. A distinctive feature of the topographies is the presence of “µ-rooms”, which are special spaces created by the depressions and elevations and are analogous to the µ-sized room in which the osteocyte will potentially live. We conducted the comparable in vivo study using dental implants with continuous (G-topography with µ-canals), discrete (S-topography with μ-cavities), and irregular (I-topography) laser-induced topographies. A histological analysis performed with the statistical method (with p-value less than 0.05) was conducted, which showed that G-topography had the highest BIC parameter and contained the highest number of mature osteocytes, indicating the best secondary stability and osseointegration. Full article
(This article belongs to the Special Issue Advancements of Nanomaterials in Oral Health and Clinical Dentistry)
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10 pages, 1849 KiB  
Article
Investigation of a Novel Injectable Chitosan Oligosaccharide—Bovine Hydroxyapatite Hybrid Dental Biocomposite for the Purposes of Conservative Pulp Therapy
by Mingkai Cai, Jithendra Ratnayake, Peter Cathro, Maree Gould and Azam Ali
Nanomaterials 2022, 12(21), 3925; https://doi.org/10.3390/nano12213925 - 7 Nov 2022
Cited by 2 | Viewed by 1377
Abstract
This study aimed to develop injectable chitosan oligosaccharide (COS) and bovine hydroxyapatite (BHA) hybrid biocomposites, and characterise their physiochemical properties for use as a dental pulp-capping material. The COS powder was prepared from chitosan through hydrolytic reactions and then dissolved in 0.2% acetic [...] Read more.
This study aimed to develop injectable chitosan oligosaccharide (COS) and bovine hydroxyapatite (BHA) hybrid biocomposites, and characterise their physiochemical properties for use as a dental pulp-capping material. The COS powder was prepared from chitosan through hydrolytic reactions and then dissolved in 0.2% acetic acid to create a solution. BHA was obtained from waste bovine bone and milled to form a powder. The BHA powder was incorporated with the COS solution at different proportions to create the COS–BHA hybrid biocomposite. Zirconium oxide (ZrO2) powder was included in the blend as a radiopacifier. The composite was characterised to evaluate its physiochemical properties, radiopacity, setting time, solubility, and pH. Fourier-transform infrared spectroscopic analysis of the COS–BHA biocomposite shows the characteristic peaks of COS and hydroxyapatite. Compositional analysis via ICP-MS and SEM-EDX shows the predominant elements present to be the constituents of COS, BHA, and ZrO2. The hybrid biocomposite demonstrated an average setting time of 1 h and 10 min and a pH value of 10. The biocomposite demonstrated solubility when placed in a physiological solution. Radiographically, the set hybrid biocomposite appears to be more radiopaque than the commercial mineral trioxide aggregate (MTA). The developed COS-BHA hybrid biocomposite demonstrated good potential as a pulp-capping agent exhibiting high pH, with a greater radiopacity and reduced setting time compared to MTA. Solubility of the biocomposite may be addressed in future studies with the incorporation of a cross-linking agent. However, further in vitro and in vivo studies are necessary to evaluate its clinical feasibility. Full article
(This article belongs to the Special Issue Advancements of Nanomaterials in Oral Health and Clinical Dentistry)
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21 pages, 6074 KiB  
Article
The Strong Protective Action of Ce3+/F− Combined Treatment on Tooth Enamel and Epithelial Cells
by Anton L. Popov, Nadia M. Zholobak, Alexander B. Shcherbakov, Taisiya O. Kozlova, Danil D. Kolmanovich, Artem M. Ermakov, Nelli R. Popova, Nikita N. Chukavin, Ernest A. Bazikyan and Vladimir K. Ivanov
Nanomaterials 2022, 12(17), 3034; https://doi.org/10.3390/nano12173034 - 1 Sep 2022
Cited by 4 | Viewed by 1675
Abstract
We studied the toxic effects of cerium and fluoride species on human dental pulp stem cells and epithelial cells of Cercopithecus aethiops as a surrogate for the human oral mucosa. The sequential use of CeCl3 and NH4F solutions in equimolar [...] Read more.
We studied the toxic effects of cerium and fluoride species on human dental pulp stem cells and epithelial cells of Cercopithecus aethiops as a surrogate for the human oral mucosa. The sequential use of CeCl3 and NH4F solutions in equimolar sub-toxic concentrations enabled the possible toxic effects of individual components to be avoided, ensuring the preservation of the metabolic activity of the cells due to the formation of CeF3 nanoparticles. Cerium fluoride nanoparticles and terbium-doped cerium fluoride nanoparticles exhibited neither cytotoxicity nor genotoxicity to dental pulp stem cells, even at high concentrations (10−4 M). In millimolar concentrations (from 10−5–10−6 M), these nanoparticles significantly increased the expression of genes responsible for the cell cycle, differentiation and proliferation. The formation of cerium fluoride on the surface of the mucous membrane and teeth provided protection against the development of carious lesions, periodontitis, ROS attacks and other inflammatory diseases of the oral cavity. Luminescent CeF3: Tb nanoparticles enabled the visualization of tooth enamel microcracks. Full article
(This article belongs to the Special Issue Advancements of Nanomaterials in Oral Health and Clinical Dentistry)
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