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Journal of Functional Biomaterials, Volume 15, Issue 9

2024 September - 37 articles

Cover Story: Polycaprolactone (PCL) scaffolds have emerged as a pivotal element in bone tissue engineering due to their favorable properties such as biocompatibility, biodegradability, and mechanical strength. This review comprehensively explores innovative fabrication techniques, including 3D printing and surface modifications, to enhance PCL scaffold performance. Emphasis is placed on the integration of biomaterials like hydroxyapatite and graphene oxide to improve cellular behavior and mechanical properties. The study provides valuable insights into optimizing scaffold structures for effective bone regeneration, offering promising directions for future clinical applications. View this paper
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Articles (37)

  • Article
  • Open Access
4 Citations
2,750 Views
24 Pages

21 September 2024

This study aimed to evaluate the biomechanical compatibility of a modular hemipelvic prosthesis by comparing stress distributions between an implanted pelvis and a healthy pelvis. Finite element analysis was used to simulate bilateral standing loads...

  • Article
  • Open Access
4 Citations
2,733 Views
22 Pages

Investigation of Mechanical and Corrosion Properties of New Mg-Zn-Ga Amorphous Alloys for Biomedical Applications

  • Viacheslav E. Bazhenov,
  • Mikhail V. Gorobinskiy,
  • Andrey I. Bazlov,
  • Vasiliy A. Bautin,
  • Andrey V. Koltygin,
  • Alexander A. Komissarov,
  • Denis V. Ten,
  • Anna V. Li,
  • Alexey Yu. Drobyshev and
  • Kwang Seon Shin
  • + 2 authors

20 September 2024

Magnesium alloys are considered as promising materials for use as biodegradable implants due to their biocompatibility and similarity to human bone properties. However, their high corrosion rate in bodily fluids limits their use. To address this issu...

  • Review
  • Open Access
2 Citations
2,142 Views
15 Pages

Research Interest in Copper Materials for Caries Management: A Bibliometric Analysis

  • Veena Wenqing Xu,
  • Mohammed Zahedul Islam Nizami,
  • Iris Xiaoxue Yin,
  • John Yun Niu,
  • Ollie Yiru Yu and
  • Chun-Hung Chu

20 September 2024

This study examined research interest in copper materials for caries management. We conducted an exhaustive literature search of English publications on copper materials for caries management. We removed duplicate publications and screened the titles...

  • Article
  • Open Access
9 Citations
4,587 Views
14 Pages

20 September 2024

Surgical sutures play a crucial role in wound closure, facilitating the tissue-healing process across various fields of medicine. The objective of this study was to analyse the impact of seasoning time during the initial days/weeks of seasoning in Ri...

  • Article
  • Open Access
3 Citations
2,381 Views
15 Pages

Electrospun Silk-ICG Composite Fibers and the Application toward Hemorrhage Control

  • Ayesha Siddiqua,
  • Elwin Clutter,
  • Olga Garklavs,
  • Hemalatha Kanniyappan and
  • Rong R. Wang

19 September 2024

In trauma and surgery, efficient hemorrhage control is crucial to avert fatal blood loss and increase the likelihood of survival. There is a significant demand for novel biomaterials capable of promptly and effectively managing bleeding. This study a...

  • Article
  • Open Access
6 Citations
3,960 Views
8 Pages

Application of the Self-Assembling Peptide Hydrogel RADA16 for Hemostasis during Tonsillectomy: A Feasibility Study

  • Joshua Michaels,
  • Anna I. Kaleva,
  • Laura Bateman,
  • Oliver Wakelam and
  • Joanna Stephens

18 September 2024

Tonsillectomy is a common surgical procedure but carries a high risk of readmission for secondary bleeding and pain. This study evaluated the feasibility and effectiveness of using the hemostatic self-assembling peptide hydrogel RADA16 (PuraBond, 3-D...

  • Article
  • Open Access
3,392 Views
16 Pages

Regeneration of Critical Calvarial Bone Defects Using Bovine Xenograft, Magnesium-Enriched Bovine Xenograft and Autologous Dentin in Rats: Micro-CT, Gene Expression and Immunohistochemical Analysis

  • Marija Čandrlić,
  • Ana Terezija Jerbić Radetić,
  • Hrvoje Omrčen,
  • Barbara Franović,
  • Lara Batičić,
  • Tamara Gulić,
  • Tea Čaljkušić-Mance,
  • Sanja Zoričić Cvek,
  • Lucija Malešić and
  • Olga Cvijanović Peloza
  • + 1 author

18 September 2024

The aim of this study was to evaluate the efficacy of autologous dentin (AD), bovine xenograft (BX) and magnesium-enriched bovine xenograft (BX + Mg) in the healing of critical cranial bone defects (CCBDs) in rats. Eighty male Wistar rats were divide...

  • Article
  • Open Access
1 Citations
4,089 Views
12 Pages

16 September 2024

(1) Background: This study aimed to establish the effect of calcium lactate enamel pretreatment related to different fluoride types and concentrations on the enamel uptake of alkali-soluble fluorides. (2) Materials: In a blind and randomized in vitro...

  • Article
  • Open Access
2 Citations
2,148 Views
18 Pages

14 September 2024

Aim: With modern dentistry advancements, children and parents have significantly raised aesthetic expectations in pediatric dentistry. Pediatric zirconia crowns (PZCs) provide a superior aesthetic appearance compared with stainless steel crowns (SSCs...

  • Article
  • Open Access
14 Citations
7,199 Views
23 Pages

In Vitro Wound-Healing Potential of Phenolic and Polysaccharide Extracts of Aloe vera Gel

  • Andreea Iosageanu,
  • Elena Mihai,
  • Ana-Maria Seciu-Grama,
  • Elena Utoiu,
  • Alexandra Gaspar-Pintiliescu,
  • Florentina Gatea,
  • Anisoara Cimpean and
  • Oana Craciunescu

13 September 2024

The present study aimed to conduct a comparative investigation of the biological properties of phenolic and polysaccharide extracts obtained using an ultrasound-assisted technique from Aloe vera gel and their effects on each stage of the wound healin...

  • Article
  • Open Access
4 Citations
3,227 Views
16 Pages

Exploring the Role of Fibrin Gels in Enhancing Cell Migration for Vasculature Formation

  • Joana A. Moura,
  • Hugh J. Barlow,
  • Shareen H. Doak,
  • Karl Hawkins,
  • Iris Muller and
  • Martin J. D. Clift

12 September 2024

A hallmark of angiogenesis is the sprouting of endothelial cells. To replicate this event in vitro, biomaterial approaches can play an essential role in promoting cell migration. To study the capacity of a scaffold of fibrin (fibrinogen:thrombin mix)...

  • Article
  • Open Access
5 Citations
1,757 Views
22 Pages

Comparison of Key Properties of Ag-TiO2 and Hydroxyapatite-Ag-TiO2 Coatings on NiTi SMA

  • Karolina Dudek,
  • Aleksandra Strach,
  • Daniel Wasilkowski,
  • Bożena Łosiewicz,
  • Julian Kubisztal,
  • Anna Mrozek-Wilczkiewicz,
  • Patryk Zioła and
  • Adrian Barylski

12 September 2024

To functionalize the NiTi alloy, multifunctional innovative nanocoatings of Ag-TiO2 and Ag-TiO2 doped with hydroxyapatite were engineered on its surface. The coatings were thoroughly characterized, focusing on surface topography and key functional pr...

  • Article
  • Open Access
1 Citations
2,140 Views
21 Pages

11 September 2024

Distant metastasis is the primary cause of unsuccessful treatment in nasopharyngeal carcinoma (NPC), suggesting the crucial need to comprehend this process. A tumor related to NPC does not have flat surfaces, but consists of confined microenvironment...

  • Article
  • Open Access
5 Citations
2,832 Views
23 Pages

Synthetic Extracellular Matrix of Polyvinyl Alcohol Nanofibers for Three-Dimensional Cell Culture

  • Thi Xuan Thuy Tran,
  • Gyu-Min Sun,
  • Hue Vy An Tran,
  • Young Hun Jeong,
  • Petr Slama,
  • Young-Chae Chang,
  • In-Jeong Lee and
  • Jong-Young Kwak

10 September 2024

An ideal extracellular matrix (ECM) replacement scaffold in a three-dimensional cell (3D) culture should induce in vivo-like interactions between the ECM and cultured cells. Highly hydrophilic polyvinyl alcohol (PVA) nanofibers disintegrate upon cont...

  • Article
  • Open Access
5 Citations
2,921 Views
17 Pages

10 September 2024

The mucosa height has always been of interest in modern implant dentistry to obtain biomimetic results. Papilla height, mucosa scalloping, and free mucosal margin level are crucial to achieve “pink aesthetics”. The aim of this study was t...

  • Article
  • Open Access
3 Citations
1,738 Views
23 Pages

9 September 2024

Clinical indications for the Ti-Zr alloy (Roxolid®) mini-implants (MDIs) in subjects with narrow ridges are still under review. The aim was to analyze peri-implant and posterior edentulous area strains dependent on the MDI number, splinting statu...

  • Article
  • Open Access
1 Citations
4,035 Views
15 Pages

Effect of Silica Nanoparticle Treatment on Adhesion between Tissue-like Substrates and In Vivo Skin Wound Sealing

  • Yeji Jeon,
  • Tae Ryeol Kim,
  • Eun Seo Park,
  • Jae Hyun Park,
  • Han Sung Youn,
  • Dae Youn Hwang and
  • Sungbaek Seo

9 September 2024

Silica nanoparticles are innovative solutions of surgical glue that can readily adhere to various tissue-like substrates without the need for time-consuming chemical reactions or ultraviolet irradiation. Herein, 10 nm-sized silica nanoparticle (SiNP1...

  • Review
  • Open Access
26 Citations
5,420 Views
30 Pages

Advances in Zinc-Containing Bioactive Glasses: A Comprehensive Review

  • Fariborz Sharifianjazi,
  • Mohammadjavad Sharifianjazi,
  • Maryam Irandoost,
  • Ketevan Tavamaishvili,
  • Mehdi Mohabatkhah and
  • Maziar Montazerian

8 September 2024

Bioactive glasses (BGs) have attracted significant attention in the biomaterials field due to their ability to promote soft and hard tissue regeneration and their potential for various clinical applications. BGs offer enriched features through the in...

  • Article
  • Open Access
4 Citations
3,338 Views
17 Pages

Healing Potential of the Marine Polysaccharides Carrageenan and Ulvan on Second-Degree Burns

  • Dimitra Statha,
  • Asimina Papaioannou,
  • Stefanos Kikionis,
  • Maria Kostaki,
  • Ioannis Sfiniadakis,
  • Andreas Vitsos,
  • Jane Anastassopoulou,
  • Efstathia Ioannou,
  • Vassilios Roussis and
  • Michail Christou Rallis

5 September 2024

The treatment of second-degree burn wounds presents a significant clinical challenge, often characterized by prolonged healing times and risk of complications. In this study, the wound healing potential of bioactive marine sulfated polysaccharides ul...

  • Article
  • Open Access
6 Citations
3,083 Views
15 Pages

Comparison of Various Surface Treatment Procedures on the Roughness and Susceptibility to Staining of Provisional Prosthodontic Materials

  • Satheesh B. Haralur,
  • Abdullah Turki Albarqi,
  • Abdulellah Gharmallah Alamodi,
  • Abdulmajeed Ali Alamri,
  • Saad Awdah Aldail,
  • Mohammed A. Al-Qarni,
  • Saeed M. AlQahtani and
  • Nasser M. Alqahtani

3 September 2024

Esthetically pleasing temporary prostheses are often necessary for extended periods in a variety of clinical scenarios. Adjustments to the occlusion or margins are commonly needed before cementing the temporary prosthesis. Therefore, it is clinically...

  • Correction
  • Open Access
1,233 Views
2 Pages

Correction: Asad et al. Anti-Inflammatory, Antipyretic, and Analgesic Potential of Chitin and Chitosan Derived from Cockroaches (Periplaneta americana) and Termites. J. Funct. Biomater. 2024, 15, 80

  • Khushbakht Asad,
  • Sumaira Shams,
  • Eliana Ibáñez-Arancibia,
  • Patricio R. De los Ríos-Escalante,
  • Farhad Badshah,
  • Farooq Ahmad,
  • Muhammad Salman Khan and
  • Asar Khan

2 September 2024

In the original publication [...]

  • Review
  • Open Access
1 Citations
3,323 Views
18 Pages

Median sternotomy and steel wires for sternal closure are the standard approach for cardiac surgery. An incomplete repair associated with chest wall motion, especially in the presence of predisposing factors, can lead to life-threatening deep sternal...

  • Article
  • Open Access
4 Citations
2,387 Views
17 Pages

Assessing Microstructural, Biomechanical, and Biocompatible Properties of TiNb Alloys for Potential Use as Load-Bearing Implants

  • Eyyup Murat Karakurt,
  • Yan Huang,
  • Yuksel Cetin,
  • Alper Incesu,
  • Huseyin Demirtas,
  • Mehmet Kaya,
  • Yasemin Yildizhan,
  • Merve Tosun and
  • Gulsah Akbas

Titanium-Niobium (TiNb) alloys are commonly employed in a number of implantable devices, yet concerns exist regarding their use in implantology owing to the biomechanical mismatch between the implant and the host tissue. Therefore, to balance the mec...

  • Article
  • Open Access
2 Citations
2,087 Views
13 Pages

Novel Chitosan-Gelatin Scaffold with Valproic Acid Augments In Vitro Osteoblast Differentiation of Mesenchymal Stem Cells

  • Maha Alghofaily,
  • Fahd Alsalleeh,
  • Lamees Alssum,
  • Manikandan Muthurangan,
  • Musaad Alfayez,
  • Michael D. Weir and
  • Hockin H. K. Xu

The study aimed to develop a biodegradable scaffold incorporating valproic acid (VPA) for improved human bone marrow-derived mesenchymal stem cell (hBMSC) proliferation, differentiation, and bone mineral synthesis. A chitosan–gelatin (CH-G) sca...

  • Article
  • Open Access
6 Citations
3,758 Views
28 Pages

The Impact of the Methacrylation Process on the Usefulness of Chitosan as a Biomaterial Component for 3D Printing

  • Marta Klak,
  • Katarzyna Kosowska,
  • Milena Czajka,
  • Magdalena Dec,
  • Sylwester Domański,
  • Agnieszka Zakrzewska,
  • Paulina Korycka,
  • Kamila Jankowska,
  • Agnieszka Romanik-Chruścielewska and
  • Michał Wszoła

Chitosan is a very promising material for tissue model printing. It is also known that the introduction of chemical modifications to the structure of the material in the form of methacrylate groups makes it very attractive for application in the biop...

  • Article
  • Open Access
9 Citations
2,836 Views
13 Pages

Acute kidney injury (AKI) is the most severe and fatal complication of sepsis resulting from infectious trauma. Currently, effective treatment options are still lacking. Dihydromyricetin is the main component extracted from Vine tea (Ampelopsis megal...

  • Article
  • Open Access
1 Citations
2,346 Views
14 Pages

Comparison of Biomechanical and Microstructural Properties of Aortic Graft Materials in Aortic Repair Surgeries

  • Haoliang Sun,
  • Zirui Cheng,
  • Xiaoya Guo,
  • Hongcheng Gu,
  • Dalin Tang and
  • Liang Wang

Mechanical mismatch between native aortas and aortic grafts can induce graft failure. This study aims to compare the mechanical and microstructural properties of different graft materials used in aortic repair surgeries with those of normal and disse...

  • Systematic Review
  • Open Access
2 Citations
2,671 Views
15 Pages

The Effectiveness of Curcumin Nanoparticle-Coated Titanium Surfaces in Osteogenesis: A Systematic Review

  • Nandita Suresh,
  • Matti Mauramo,
  • Tuomas Waltimo,
  • Timo Sorsa and
  • Sukumaran Anil

(1) Background: This systematic review critically appraises and synthesizes evidence from in vitro studies investigating the effects of curcumin nanoparticles on titanium surface modification, focusing on cell adhesion, proliferation, osteogenic diff...

  • Article
  • Open Access
5 Citations
3,128 Views
13 Pages

Investigating the Mechanisms of Discoloration in Modern Dental Materials: A Comprehensive Characterization Approach

  • Maria Gawriołek,
  • Naisargi Varma,
  • Amadeusz Hernik,
  • Wojciech Eliasz,
  • Marta Strykowska,
  • Elżbieta Paszyńska,
  • Beata Czarnecka and
  • Marek Sikorski

In general, patients’ opinions on reaching ideal esthetics while restoring dental tissues is one of the most important part of the oral treatment. Unfortunately, discoloration of dental materials may occur due to intrinsic and extrinsic factors...

  • Article
  • Open Access
1 Citations
2,196 Views
18 Pages

Effect of Photoaging on the Structure, Optical Properties and Roughness of One-Shade Composite Restoratives

  • Aikaterini Petropoulou,
  • Maria Dimitriadi,
  • Spiros Zinelis,
  • Maria Antoniadou and
  • George Eliades

The aim of the study was to evaluate changes in the degree of C=C conversion (DC%), chemical structure, optical properties and roughness of one-shade composites before/after photoaging. Τhe one-shade materials tested were Charisma Topaz One (CHT)...

  • Article
  • Open Access
5 Citations
3,177 Views
12 Pages

Surface Analysis of Orthodontic Mini-Implants after Their Clinical Use

  • Tamara Rahela Ioana,
  • Filip George Boeru,
  • Iulian Antoniac,
  • Ioana Mitruț,
  • Ionela Elisabeta Staicu,
  • Anne Marie Rauten,
  • Willi Andrei Uriciuc and
  • Horia Octavian Manolea

Temporary anchorage devices (TADs) are orthodontic mini-implants with remarkable characteristics that, once inserted, present mechanical retention (primary stability) without the process of bone osseointegration. However, interaction with the biologi...

  • Review
  • Open Access
47 Citations
8,627 Views
18 Pages

Polycaprolactone in Bone Tissue Engineering: A Comprehensive Review of Innovations in Scaffold Fabrication and Surface Modifications

  • Hsin-Yu Liang,
  • Wei-Keung Lee,
  • Jui-Tsen Hsu,
  • Jie-Yu Shih,
  • Tien-Li Ma,
  • Thi Thuy Tien Vo,
  • Chiang-Wen Lee,
  • Ming-Te Cheng and
  • I-Ta Lee

Bone tissue engineering has seen significant advancements with innovative scaffold fabrication techniques such as 3D printing. This review focuses on enhancing polycaprolactone (PCL) scaffold properties through structural modifications, including sur...

  • Article
  • Open Access
3 Citations
1,904 Views
14 Pages

The Exponential Shapeshifting Response of N-Vinylcaprolactam Hydrogel Bilayers Due to Temperature Change for Potential Minimally Invasive Surgery

  • Billy Shu Hieng Tie,
  • Mark Daly,
  • Shuo Zhuo,
  • Elaine Halligan,
  • Gavin Keane,
  • Joseph Geever and
  • Luke Geever

Poly (N-vinylcaprolactam) (PNVCL) and poly (N-isopropylacrylamide) (PNIPAm) are two popular negatively temperature-responsive hydrogels, due to their biocompatibility, softness, hydrophilicity, superabsorbency, viscoelasticity, and near-physiological...

  • Review
  • Open Access
59 Citations
9,680 Views
33 Pages

The rising demand for effective bone regeneration has underscored the limitations of traditional methods like autografts and allografts, including donor site morbidity and insufficient biological signaling. This review examines nanoparticles (NPs) in...

  • Article
  • Open Access
3 Citations
2,301 Views
18 Pages

Insights into the Dual Anticancer and Antibacterial Activities of Composites Based on Silver Camphorimine Complexes

  • Joana P. Costa,
  • Sílvia A. Sousa,
  • Jorge H. Leitão,
  • Fernanda Marques,
  • Marta M. Alves and
  • M. Fernanda N. N. Carvalho

Hydroxyapatite (HAp) is a widely used biocompatible material in orthopedic composite preparations. However, HAp composites that exhibit both anticancer and antibacterial activities through bioactive coordination complexes are relatively rare. To expl...

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J. Funct. Biomater. - ISSN 2079-4983