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Journal of Functional Biomaterials, Volume 15, Issue 10

October 2024 - 37 articles

Cover Story: Dermal substitutes are frequently used for the initial treatment of large full-thickness skin defects in combination with split-thickness skin graft coverage. However, these dermal substitutes first require an adequate vascularization and integration into the surrounding host tissue before being successfully covered, which is a time-consuming process. To overcome this problem, dermal substitutes were seeded with nanofat, an autologous fat derivative with potent angiogenic and regenerative effects. In a murine dorsal skinfold chamber model, this seeding of nanofat accelerated the vascularization and tissue integration of the implanted dermal substitutes without affecting their good biocompatibility. View this paper
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Articles (37)

  • Article
  • Open Access
9 Citations
2,874 Views
19 Pages

Mechanical and Corrosion Behaviour in Simulated Body Fluid of As-Fabricated 3D Porous L-PBF 316L Stainless Steel Structures for Biomedical Implants

  • Pedro Nogueira,
  • João Magrinho,
  • Luis Reis,
  • Augusto Moita de Deus,
  • Maria Beatriz Silva,
  • Pedro Lopes,
  • Luís Oliveira,
  • António Castela,
  • Ricardo Cláudio and
  • Jorge L. Alves
  • + 3 authors

21 October 2024

Laser powder bed fusion (L-PBF) is one of the most promising additive manufacturing technologies for creating customised 316L Stainless Steel (SS) implants with biomimetic characteristics, controlled porosity, and optimal structural and functional pr...

  • Article
  • Open Access
2 Citations
2,376 Views
22 Pages

A pH-Responsive Ti-Based Local Drug Delivery System for Osteosarcoma Therapy

  • Qinle Xiao,
  • Changjun Wan,
  • Zhe Zhang,
  • Hui Liu,
  • Pingting Liu,
  • Qianli Huang and
  • Dapeng Zhao

21 October 2024

Osteosarcoma is one of the major bone cancers, especially for youngsters. The current treatment usually requires systemic chemotherapy and the removal of bone tumors. Titanium (Ti)-based implants can be modified as local drug delivery (LDD) systems f...

  • Article
  • Open Access
6 Citations
2,309 Views
17 Pages

PLLA/GO Scaffolds Filled with Canine Placenta Hydrogel and Mesenchymal Stem Cells for Bone Repair in Goat Mandibles

  • Thamires Santos-Silva,
  • Inácio Silva Viana,
  • Andrea Barros Piazzon S. Queiroz,
  • Fabrício Singaretti de Oliveira,
  • Bianca de Oliveira Horvath-Pereira,
  • Leandro Norberto da Silva-Júnior,
  • Michelle Silva Araujo,
  • Paulo Alescio Canola,
  • Luís Gustavo Gosuen G. Dias and
  • Marcelo Melo Soares
  • + 1 author

20 October 2024

Bone defects in animals can arise from various causes, including diseases, neoplasms, and most commonly, trauma. Comminuted fractures that exceed the critical size may heal poorly due to deficient or interrupted vascularization, resulting in an insuf...

  • Article
  • Open Access
1 Citations
3,979 Views
14 Pages

Benzyldimethyldodecyl Ammonium Chloride-Doped Denture-Based Resin: Impact on Strength, Surface Properties, Antifungal Activities, and In Silico Molecular Docking Analysis

  • Sarah Aldulaijan,
  • Raghad Alruwili,
  • Rawan Almulaify,
  • Fatimah A. Alhassan,
  • Yousif A. Al-Dulaijan,
  • Faris A. Alshahrani,
  • Lamia Mokeem,
  • Mohammed M. Gad,
  • Mary Anne S. Melo and
  • Abdulrahman A. Balhaddad

18 October 2024

Candida albicans (C. albicans) adhering to denture-based resins (DBRs) is a known cause of denture stomatitis. A new approach to prevent denture stomatitis is to include antimicrobial substances within DBRs. Here, we examined the mechanical performan...

  • Article
  • Open Access
2 Citations
1,875 Views
16 Pages

A Polyurethane Electrospun Membrane Loaded with Bismuth Lipophilic Nanoparticles (BisBAL NPs): Proliferation, Bactericidal, and Antitumor Properties, and Effects on MRSA and Human Breast Cancer Cells

  • Jesús Alejandro Torres-Betancourt,
  • Rene Hernández-Delgadillo,
  • Juan Valerio Cauich-Rodríguez,
  • Diego Adrián Oliva-Rico,
  • Juan Manuel Solis-Soto,
  • Claudia María García-Cuellar,
  • Yesennia Sánchez-Pérez,
  • Nayely Pineda-Aguilar,
  • Samantha Flores-Treviño and
  • Irene Meester
  • + 4 authors

16 October 2024

Electrospun membranes (EMs) have a wide range of applications, including use as local delivery systems. In this study, we manufactured a polyurethane Tecoflex™ EM loaded with bismuth-based lipophilic nanoparticles (Tecoflex™ EMs-BisBAL NP...

  • Systematic Review
  • Open Access
22 Citations
8,898 Views
20 Pages

Stem Cells: Present Understanding and Prospects for Regenerative Dentistry

  • Angelo Michele Inchingolo,
  • Alessio Danilo Inchingolo,
  • Paola Nardelli,
  • Giulia Latini,
  • Irma Trilli,
  • Laura Ferrante,
  • Giuseppina Malcangi,
  • Andrea Palermo,
  • Francesco Inchingolo and
  • Gianna Dipalma

15 October 2024

Regenerative medicine in dentistry focuses on repairing damaged oral tissues using advanced tools like stem cells, biomaterials, and tissue engineering (TE). Mesenchymal stem cells (MSCs) from dental sources, such as dental pulp and periodontal ligam...

  • Systematic Review
  • Open Access
2 Citations
2,850 Views
85 Pages

15 October 2024

Prosthetic joint infection (PJI) is a major complication following total arthroplasty. Rising antimicrobial resistance (AMR) to antibiotics will further increase therapeutic insufficiency. New antibacterial technologies are being developed to prevent...

  • Article
  • Open Access
2 Citations
3,393 Views
11 Pages

15 October 2024

The initial efficacy of placental extracts (Pla-Exts) and human mesenchymal stem-cell-derived exosomes (hMSC-Exo) against aging-induced stress in human dermal fibroblasts (HDFs) was examined. The effect of Pla-Ext alone, hMSC-Exo alone, the combined...

  • Article
  • Open Access
2 Citations
1,800 Views
18 Pages

Role of Niobium on the Passivation Mechanisms of TiHfZrNb High-Entropy Alloys in Hanks’ Simulated Body Fluid

  • Ayoub Tanji,
  • Xuesong Fan,
  • Ridwan Sakidja,
  • Peter K. Liaw and
  • Hendra Hermawan

14 October 2024

A family of TiHfZrNb high-entropy alloys has been considered novel biomaterials for high-performance, small-sized implants. The present work evaluates the role of niobium on passivation kinetics and electrochemical characteristics of passive film on...

  • Article
  • Open Access
2 Citations
1,927 Views
14 Pages

13 October 2024

Silver nanoparticles (Ag NPs) conjugated with amino-functionalized cellulose nanofibrils (NH2−CNFs) were in situ-prepared by reducing silver ions with free amino groups from NH2−CNFs. The spectroscopy and transmission electron microscopy...

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J. Funct. Biomater. - ISSN 2079-4983