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Journal of Clinical Medicine, Volume 9, Issue 11

November 2020 - 409 articles

Cover Story: Perturbations in mitochondrial dysfunction play significant role in the pathogenesis of HF. Pathophysiological mechanisms leading to mitochondrial dysfunction in HF are numerous and range from changes in morphology and dynamics; to altered endoplasmic reticulum (ER)-mitochondrial (mt) tethering due to altered signaling and calcium cycling at the ER-mt interphase; enhanced mt-calcium uptake and overload; increased reactive oxygen species and apoptosis; and decreased mt-biogenesis, and oxidative capacity. Investigational drugs targeting specific areas of mt-dysfunction are being investigated. There remain an unmet need to explore molecular mechanisms modulating the multiplicity of mt-dysfunction in HF for better effective therapeutic interventions. View this paper
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Articles (409)

  • Article
  • Open Access
15 Citations
4,117 Views
13 Pages

Improvement of Gait after 4 Weeks of Wearable Focal Muscle Vibration Therapy for Individuals with Diabetic Peripheral Neuropathy

  • Josiah Rippetoe,
  • Hongwu Wang,
  • Shirley A. James,
  • Carol Dionne,
  • Bethany Block and
  • Matthew Beckner

22 November 2020

People with diabetic peripheral neuropathy (DPN) experience lower quality of life caused by associated balance, posture, and gait impairments. While focal muscle vibration (FMV) has been associated with improvements in gait performance in individuals...

  • Article
  • Open Access
17 Citations
3,954 Views
12 Pages

Risk and Severity of COVID-19 and ABO Blood Group in Transcatheter Aortic Valve Patients

  • Marion Kibler,
  • Laurent Dietrich,
  • Mohamad Kanso,
  • Adrien Carmona,
  • Benjamin Marchandot,
  • Kensuke Matsushita,
  • Antonin Trimaille,
  • Cécile How-Choong,
  • Albane Odier and
  • Gabrielle Gennesseaux
  • + 8 authors

22 November 2020

While cardiovascular disease has been associated with an increased risk of coronavirus disease 2019 (COVID-19), no studies have described its clinical course in patients with aortic stenosis who had undergone transcatheter aortic valve replacement (T...

  • Article
  • Open Access
15 Citations
5,547 Views
10 Pages

Modified Clavien–Dindo Classification and Outcome Prediction in Free Flap Reconstruction among Patients with Head and Neck Cancer

  • Wei-Ling Jan,
  • Hung-Chi Chen,
  • Chang-Cheng Chang,
  • Hsin-Han Chen,
  • Pin-Keng Shih and
  • Tsung-Chun Huang

22 November 2020

Because of limitations caused by unique complications of free flap reconstruction, the Clavien–Dindo classification was modified to include grade “IIIc” for “partial or total free flap failure.” From 2013 to 2018, 116 pa...

  • Article
  • Open Access
13 Citations
3,601 Views
13 Pages

Utility of Blood Parameters to Detect Complications during Long-Term Follow-Up in Patients with Diabetic Foot Osteomyelitis

  • Aroa Tardáguila-García,
  • Yolanda García Álvarez,
  • Esther García-Morales,
  • Francisco Javier Álvaro-Afonso,
  • Irene Sanz-Corbalán and
  • José Luis Lázaro-Martínez

22 November 2020

The evidence is still unclear regarding the role of blood parameters in detecting complications in patients who suffer from diabetic foot osteomyelitis (DFO). In this study, the aim was to identify the capacity of different blood parameters in the di...

  • Review
  • Open Access
10 Citations
4,038 Views
17 Pages

Effectiveness of Active Therapy-Based Training to Improve the Balance in Patients with Fibromyalgia: A Systematic Review with Meta-Analysis

  • María Del-Moral-García,
  • Esteban Obrero-Gaitán,
  • Daniel Rodríguez-Almagro,
  • Manuel Rodríguez-Huguet,
  • María Catalina Osuna-Pérez and
  • Rafael Lomas-Vega

22 November 2020

Balance impairment is a frequent disorder in patients with fibromyalgia (FMS), increasing the risk of falls and decreasing physical function and quality of life. In recent years, the use of active therapy-based training (ATBT) has increased, with the...

  • Review
  • Open Access
13 Citations
3,927 Views
14 Pages

Predictors and Biomarkers of Subclinical Leaflet Thrombosis after Transcatheter Aortic Valve Implantation

  • Katarzyna Pieniak,
  • Szymon Jędrzejczyk,
  • Olaf Domaszk,
  • Kajetan Grodecki,
  • Bartosz Rymuza,
  • Zenon Huczek,
  • Janusz Kochman,
  • Krzysztof J. Filipiak and
  • Aleksandra Gąsecka

21 November 2020

Transcatheter aortic valve implantation (TAVI) is a recent revolutionary treatment for high-risk patients with severe aortic stenosis who are not suitable for surgery, expanding to intermediate and low-risk patients. Valve leaflet thrombosis (LT) is...

  • Article
  • Open Access
8 Citations
2,807 Views
13 Pages

Pre-Hospital Management of Critically Ill Patients with SARS-CoV-2 Infection: A Retrospective Multicenter Study

  • Pierrick Le Borgne,
  • Mathieu Oberlin,
  • Adrien Bassand,
  • Laure Abensur Vuillaume,
  • Yannick Gottwalles,
  • Marc Noizet,
  • Stéphane Gennai,
  • Florent Baicry,
  • Deborah Jaeger and
  • Nicolas Girerd
  • + 3 authors

21 November 2020

Introduction: The COVID-19 outbreak had a major impact on healthcare systems worldwide. Our study aims to describe the characteristics and therapeutic emergency mobile service (EMS) management of patients with vital distress due to COVID-19, their in...

  • Article
  • Open Access
33 Citations
3,591 Views
9 Pages

Characteristics and Outcome for Persons with Diabetic Foot Ulcer and No-Option Critical Limb Ischemia

  • Marco Meloni,
  • Valentina Izzo,
  • Valerio Da Ros,
  • Daniele Morosetti,
  • Matteo Stefanini,
  • Enrico Brocco,
  • Laura Giurato,
  • Roberto Gandini and
  • Luigi Uccioli

21 November 2020

The study aimed to evaluate clinical and vascular characteristics, as well as outcomes, for diabetic persons with foot ulceration and no-option critical limb ischemia (CLI). The study group included a sample of patients admitted to our diabetic foot...

  • Review
  • Open Access
29 Citations
4,861 Views
16 Pages

21 November 2020

An outbreak of SARS-CoV-2 infection in December 2019 became a major global concern in 2020. Since then, several articles analyzing the course, complications and mechanisms of the infection have appeared. However, there are very few papers explaining...

  • Article
  • Open Access
28 Citations
3,681 Views
9 Pages

21 November 2020

The Medication Quantification Scale III (MQS) is a tool to represent the negative impact of medication. A reduction in medication can serve as an indicator to evaluate treatment success. However, no cut-off value has yet been determined to evaluate w...

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J. Clin. Med. - ISSN 2077-0383