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Journal of Clinical Medicine, Volume 8, Issue 5

May 2019 - 191 articles

Cover Story: The cover of this Issue of Journal of Clinical Medicine shows a microscopic image of dendritic cells (DCs). DCs are a type of immune cells specialized in processing and presenting antigens to T cells. These antigen-primed T cells, in turn, can become cytotoxic toward target cells (e.g. tumor cells) that express the designated antigen. In addition, DCs can also stimulate other anti-cancer immune effector cells, such as natural killer cells. These characteristics render DCs attractive candidates for cell-based immunotherapy of cancers, including acute myeloid leukemia (AML). DC-based immunotherapy has shown promise in this highly aggressive type of blood cancer, in particular after chemotherapy-induced remission to prevent AML relapse. In this article, Van Acker et al. review the clinical evidence obtained so far with this form of immunotherapy in patients with AML. View this paper
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Articles (191)

  • Article
  • Open Access
36 Citations
19,240 Views
14 Pages

Sleep after Heavy Alcohol Consumption and Physical Activity Levels during Alcohol Hangover

  • Lydia E. Devenney,
  • Kieran B. Coyle,
  • Thomas Roth and
  • Joris C. Verster

Alcohol consumption can negatively affect sleep quality. The current study examined the impact of an evening of alcohol consumption on sleep, and next day activity levels and alcohol hangover. n = 25 healthy social drinkers participated in a naturali...

  • Review
  • Open Access
45 Citations
8,480 Views
23 Pages

Can Metabolic Pathways Be Therapeutic Targets in Rheumatoid Arthritis?

  • Elsa Sanchez-Lopez,
  • Anyan Cheng and
  • Monica Guma

The metabolic rewiring of tumor cells and immune cells has been viewed as a promising source of novel drug targets. Many of the molecular pathways implicated in rheumatoid arthritis (RA) directly modify synovium metabolism and transform the resident...

  • Article
  • Open Access
24 Citations
4,955 Views
10 Pages

Impact of Lymphocyte and Neutrophil Counts on Mortality Risk in Severe Community-Acquired Pneumonia with or without Septic Shock

  • Estel Güell,
  • Marta Martín-Fernandez,
  • Mari C. De la Torre,
  • Elisabet Palomera,
  • Mateu Serra,
  • Rafael Martinez,
  • Manel Solsona,
  • Gloria Miró,
  • Jordi Vallès and
  • Samuel Fernández
  • + 6 authors

Background: Community-acquired pneumonia (CAP) is a frequent cause of death worldwide. As recently described, CAP shows different biological endotypes. Improving characterization of these endotypes is needed to optimize individualized treatment of th...

  • Article
  • Open Access
20 Citations
6,555 Views
16 Pages

Aim: Metabolic parameters, such as blood pressure, glucose, lipid levels, and body weight, can interact with each other, and this clustering of metabolic risk factors is related to the progression to end-stage renal disease (ESRD). The effect of vari...

  • Article
  • Open Access
22 Citations
4,305 Views
8 Pages

Thyroid Hormones and Spermatozoa: In Vitro Effects on Sperm Mitochondria, Viability and DNA Integrity

  • Rosita A. Condorelli,
  • Sandro La Vignera,
  • Laura M. Mongioì,
  • Angela Alamo,
  • Filippo Giacone,
  • Rossella Cannarella and
  • Aldo E. Calogero

The aim of this study wasto assess the in vitro effects of levothyroxine (LT4) on conventional and bio-functional sperm parameters and its implications on fertility. Patients with male idiopathic infertility were enrolled and subjected to examination...

  • Article
  • Open Access
16 Citations
5,536 Views
15 Pages

The gender identity of trans individuals influences their treatment preferences, and this in turn seems to affect their individual treatment progress. However, there has been no research which—next to the impact of gender identity on treatment...

  • Article
  • Open Access
39 Citations
7,869 Views
19 Pages

Molecular Genetics and Interferon Signature in the Italian Aicardi Goutières Syndrome Cohort: Report of 12 New Cases and Literature Review

  • Jessica Garau,
  • Vanessa Cavallera,
  • Marialuisa Valente,
  • Davide Tonduti,
  • Daisy Sproviero,
  • Susanna Zucca,
  • Domenica Battaglia,
  • Roberta Battini,
  • Enrico Bertini and
  • Silvia Cappanera
  • + 29 authors

Aicardi-Goutières syndrome (AGS) is a genetically determined early onset encephalopathy characterized by cerebral calcification, leukodystrophy, and increased expression of interferon-stimulated genes (ISGs). Up to now, seven genes (TREX1, RNASEH2B,...

  • Article
  • Open Access
22 Citations
4,159 Views
14 Pages

Infliximab Induced a Dissociated Response of Severe Periodontal Biomarkers in Rheumatoid Arthritis Patients

  • Mélanie Rinaudo-Gaujous,
  • Vincent Blasco-Baque,
  • Pierre Miossec,
  • Philippe Gaudin,
  • Pierre Farge,
  • Xavier Roblin,
  • Thierry Thomas,
  • Stephane Paul and
  • Hubert Marotte

Objective: Rheumatoid arthritis and periodontal disease are associated together, but the effect of therapy provided for one disease to the second one remained under-investigated. This study investigated effect of infliximab therapy used to treat rheu...

  • Article
  • Open Access
46 Citations
6,805 Views
8 Pages

Epidemiology and Burden of Diabetic Foot Ulcer and Peripheral Arterial Disease in Korea

  • Dong-il Chun,
  • Sangyoung Kim,
  • Jahyung Kim,
  • Hyeon-Jong Yang,
  • Jae Heon Kim,
  • Jae-ho Cho,
  • Young Yi,
  • Woo Jong Kim and
  • Sung Hun Won

Information about the epidemiology of diabetic foot ulcer (DFU) with peripheral arterial disease (PAD) is likely to be crucial for predicting future disease progression and establishing a health care budget. We investigated the incidence and prevalen...

  • Review
  • Open Access
21 Citations
6,671 Views
16 Pages

Epithelial-Mesenchymal Plasticity in Organotropism Metastasis and Tumor Immune Escape

  • Xiang Nan,
  • Jiang Wang,
  • Haowen Nikola Liu,
  • Stephen T.C. Wong and
  • Hong Zhao

Most cancer deaths are due to metastasis, and almost all cancers have their preferential metastatic organs, known as “organotropism metastasis”. Epithelial-mesenchymal plasticity has been described as heterogeneous and dynamic cellular di...

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J. Clin. Med. - ISSN 2077-0383Creative Common CC BY license