Table of Contents
J. Clin. Med., Volume 8, Issue 5 (May 2019) – 191 articles
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Cover Story (view full-size image) The cover of this Issue of Journal of Clinical Medicine shows a microscopic image of dendritic [...] Read more. The cover of this Issue of Journal of Clinical Medicine shows a microscopic image of dendritic cells (DCs). DCs are a type of immune cells specialized in processing and presenting antigens to T cells. These antigen-primed T cells, in turn, can become cytotoxic toward target cells (e.g. tumor cells) that express the designated antigen. In addition, DCs can also stimulate other anti-cancer immune effector cells, such as natural killer cells. These characteristics render DCs attractive candidates for cell-based immunotherapy of cancers, including acute myeloid leukemia (AML). DC-based immunotherapy has shown promise in this highly aggressive type of blood cancer, in particular after chemotherapy-induced remission to prevent AML relapse. In this article, Van Acker et al. review the clinical evidence obtained so far with this form of immunotherapy in patients with AML. View this paper