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Quantifying Cancer Epithelial-Mesenchymal Plasticity and its Association with Stemness and Immune Response
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Epithelial-Mesenchymal Plasticity in Organotropism Metastasis and Tumor Immune Escape

Center for Biomedical Engineering, University of Science and Technology of China, Hefei 230052, China
Department of Systems Medicine and Bioengineering, Houston Methodist Cancer Center, Weill Cornell Medicine, Houston, TX 77030, USA
Department of Orthopedics, Tongji Hospital, Wuhan 430050, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Clin. Med. 2019, 8(5), 747;
Received: 25 March 2019 / Revised: 21 May 2019 / Accepted: 22 May 2019 / Published: 25 May 2019
PDF [2558 KB, uploaded 25 May 2019]


Most cancer deaths are due to metastasis, and almost all cancers have their preferential metastatic organs, known as “organotropism metastasis”. Epithelial-mesenchymal plasticity has been described as heterogeneous and dynamic cellular differentiation states, supported by emerging experimental evidence from both molecular and morphological levels. Many molecular factors regulating epithelial-mesenchymal plasticity have tissue-specific and non-redundant properties. Reciprocally, cellular epithelial-mesenchymal plasticity contributes to shaping organ-specific pre-metastatic niche (PMN) including distinct local immune landscapes, mainly through secreted bioactive molecular factors. Here, we summarize recent progress on the involvement of tumor epithelial-mesenchymal plasticity in driving organotropic metastasis and regulating the function of different immune cells in organ-specific metastasis. View Full-Text
Keywords: organotropism metastasis; EMT heterogeneity; tumor immune escape; cell–cell communication organotropism metastasis; EMT heterogeneity; tumor immune escape; cell–cell communication

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Nan, X.; Wang, J.; Liu, H.N.; Wong, S.T.; Zhao, H. Epithelial-Mesenchymal Plasticity in Organotropism Metastasis and Tumor Immune Escape. J. Clin. Med. 2019, 8, 747.

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