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Journal of Clinical Medicine, Volume 14, Issue 8

April-2 2025 - 323 articles

Cover Story: Metastatic hormone-sensitive prostate cancer (mHSPCa) may present de novo or as significant disease progression and typically requires systemic treatment. Recently, triplet therapy—integrating ADT, docetaxel, and an ARSI—has emerged as an effective approach, particularly in high-volume metastatic disease, as supported by ARASENS and PEACE-1. Advances in imaging, such as PSMA PET-CT, have improved disease detection, allowing for earlier detection of metastasis and timely initiation of appropriate therapy. Genomic profiling has enabled the development of biomarker-driven, personalized treatment strategies. As novel therapies, targeted agents, and immunotherapies undergo investigation, optimizing treatment selection based on disease burden, molecular characteristics, and patient factors will be essential. View this paper
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Articles (323)

  • Article
  • Open Access
999 Views
11 Pages

Wrist Joint Restriction: Impact on Foot Pressure, Center of Gravity, and the Role of the Dominant Hand

  • Leire Cruz Gambero,
  • Gabriel A. Gijón-Noguerón,
  • Salvador Díaz Miguel,
  • Javier Barón-López and
  • Cantero-Téllez Raquel

19 April 2025

Background: Wrist immobilization is a common clinical intervention for wrist injuries; however, its repercussions on gait parameters and plantar support have not been extensively investigated. Objectives: The purpose of the study was to determine whe...

  • Article
  • Open Access
651 Views
14 Pages

The Hungarian Adaptation, Validity and Reliability of the Questionnaire “Health Questionnaire on Back Care Knowledge in Daily Life Physical Activities for Adolescent Students” Examining the Back Care Knowledge and Spine Disease Prevention

  • Brigitta Szilágyi,
  • Alexandra Makai,
  • Borbála Magyar,
  • Nóra Gulyás-Tanács,
  • Gábor Rébék-Nagy,
  • Klaudia Gál-Kiss,
  • Péter Sándor Tardi,
  • Zsófia Kovács-Szabó,
  • Melinda Járomi and
  • Nikolett Tumpek

19 April 2025

Background: There is a small number of questionnaires for children in the international literature that assess back care knowledge and spine disease prevention. A back care knowledge questionnaire in Hungarian for 14–17-year-old children is not...

  • Article
  • Open Access
1 Citations
1,860 Views
17 Pages

19 April 2025

Objective: In assisted reproductive technology (ART), achieving a successful pregnancy requires optimizing an embryo culture and selecting the single embryo with the highest implantation potential, capable of resulting in a healthy pregnancy. The pri...

  • Article
  • Open Access
2 Citations
2,233 Views
12 Pages

Prognostic Value of the Lactate/Albumin Ratio in Sepsis-Related Mortality: An Exploratory Study in a Tertiary Care Center with Limited Resources in Western Mexico

  • Octavio Ponce-Orozco,
  • Berenice Vicente-Hernandez,
  • Sol Ramirez-Ochoa,
  • Luis Asdrúval Zepeda-Gutiérrez,
  • Mauricio Alfredo Ambriz-Alarcón,
  • Gabino Cervantes-Guevara,
  • Alejandro Gonzalez-Ojeda,
  • Clotilde Fuentes-Orozco,
  • Francisco Javier Hernandez-Mora and
  • Guillermo A. Cervantes-Cardona
  • + 2 authors

19 April 2025

Background and Objectives: Sepsis is a critical condition with high mortality rates worldwide. The early identification of patients at an elevated risk of mortality remains a significant clinical challenge. The lactate/albumin (L/A) ratio has emerged...

  • Article
  • Open Access
719 Views
13 Pages

Visual Acuity Among Portuguese School-Aged Population

  • María Ibeth Peñaloza-Barbosa,
  • Clara Martinez-Perez,
  • Cristina Andreu-Vázquez,
  • Miguel Ángel Sánchez-Tena and
  • Cristina Alvarez-Peregrina

19 April 2025

Background/Objectives: Visual acuity (VA) screening is highly valid in school-aged children for detecting visual impairments. This study aims to provide a comprehensive profile of VA among school-aged children (6–17 years old) from Lisbon, Port...

  • Article
  • Open Access
1 Citations
4,703 Views
13 Pages

Trends in Celecoxib Prescribing: A Single Institution 16-Month Review

  • Ivo H. Cerda,
  • Helen Jung,
  • Maria C. Guerrero,
  • Rodrigo Diez Tafur,
  • Robert Jason Yong,
  • Christopher L. Robinson and
  • Jamal J. Hasoon

19 April 2025

Background/Objectives: Celecoxib, a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID), is widely prescribed for pain management due to its efficacy and improved gastrointestinal safety profile compared to traditional NSAIDs. Understanding p...

  • Article
  • Open Access
1,131 Views
9 Pages

Enhancing Prostate Cancer Diagnosis: A Comparative Analysis of Combined Fusion and Systematic Biopsy Methods—A Single-Center Study

  • Emil Kania,
  • Maciej Janica,
  • Grzegorz Hrehoruk,
  • Przemysław Kurowski,
  • Adam Ostasiewicz,
  • Paweł Samocik,
  • Robert Kozłowski and
  • Jacek Robert Janica

19 April 2025

Background/Objectives: Prostate cancer is the second most prevalent malignancy in men globally, typically suspected following abnormalities found during digital rectal examination (DRE) or elevated PSA levels. This study aimed to evaluate and compare...

  • Article
  • Open Access
1 Citations
1,358 Views
9 Pages

19 April 2025

Background/Objectives: This study examines the clinical characteristics of Pneumocystis jirovecii pneumonia (PjP) in non-Human immunodeficiency virus (HIV) patients in Hungary to describe its local epidemiological properties. Methods: Our study was c...

  • Article
  • Open Access
2,149 Views
8 Pages

Clinical and Radiological Analysis of Odontogenic Sinusitis: A Retrospective Study

  • Shin Hyuk Yoo,
  • Hahn Jin Jung,
  • Soo Kyoung Park and
  • Ji-Hun Mo

19 April 2025

Background/Objectives: Odontogenic sinusitis (ODS) is a distinct subtype of chronic rhinosinusitis that arises from dental pathology, with unique etiologies and treatment strategies. This study aimed to evaluate the clinical features, radiological fi...

  • Article
  • Open Access
3,267 Views
13 Pages

19 April 2025

Background: Hypogonadism frequently occurs among men with chronic kidney disease (CKD) and is a highly unfavorable prognostic factor. Therefore, a simple and common screening for testosterone deficiency may be important. The measurement of testostero...

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J. Clin. Med. - ISSN 2077-0383