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Journal of Clinical Medicine, Volume 14, Issue 8

April-2 2025 - 323 articles

Cover Story: Metastatic hormone-sensitive prostate cancer (mHSPCa) may present de novo or as significant disease progression and typically requires systemic treatment. Recently, triplet therapy—integrating ADT, docetaxel, and an ARSI—has emerged as an effective approach, particularly in high-volume metastatic disease, as supported by ARASENS and PEACE-1. Advances in imaging, such as PSMA PET-CT, have improved disease detection, allowing for earlier detection of metastasis and timely initiation of appropriate therapy. Genomic profiling has enabled the development of biomarker-driven, personalized treatment strategies. As novel therapies, targeted agents, and immunotherapies undergo investigation, optimizing treatment selection based on disease burden, molecular characteristics, and patient factors will be essential. View this paper
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Articles (323)

  • Review
  • Open Access
1,825 Views
12 Pages

Review Article: Contemporary Transcatheter Heart Valves for TAVI in Bicuspid Aortic Anatomy

  • Chrysavgi Simopoulou,
  • Omar Oliva,
  • Vincenzo Cesario,
  • Nicolas Dumonteil,
  • Didier Tchetche and
  • Chiara De Biase

20 April 2025

Bicuspid aortic valve (BAV) is the most common congenital heart disease, affecting 0.5–2% of the population and often leading to early aortic valve degeneration. While surgical aortic valve replacement (SAVR) remains the gold standard for treat...

  • Article
  • Open Access
1,041 Views
9 Pages

20 April 2025

Purpose: The aim of this study was to investigate the effectiveness and reliability of point-of-care ultrasonography (POCUS) in the differential diagnosis of azoospermia. Materials and methods: Records of 175 patients who had previously been diagnose...

  • Article
  • Open Access
1,363 Views
14 Pages

20 April 2025

Background: Sodium zirconium cyclosilicate (SZC) is a novel potassium-binding agent with strong evidence supporting its efficacy in normalizing hyperkalemia. However, the long-term prognostic impact of SZC-integrated medical therapy in patients with...

  • Systematic Review
  • Open Access
2,720 Views
20 Pages

Challenges and Opportunities in Achieving Asthma Remission

  • Elena Cojocaru,
  • Raluca Ioana Arcana,
  • Steluta Radu,
  • Antigona Carmen Trofor and
  • Cristian Cojocaru

20 April 2025

Background: Asthma is a chronic inflammatory disorder in millions of individuals across the globe with high morbidity, mortality, and health care costs. Despite advances in asthma treatment, long-term remission is a challenging target to achieve. Obj...

  • Article
  • Open Access
1,303 Views
17 Pages

Laparoscopic vs. Open-Groin Hernia Repair in Romania—A Populational Study

  • Nicolae Dragos Garofil,
  • Mihai Zurzu,
  • Mircea Nicolae Bratucu,
  • Vlad Paic,
  • Anca Tigora,
  • Cristian Vladescu,
  • Silviu Badoiu,
  • Victor Dan Eugen Strambu,
  • Petru Adrian Radu and
  • Sandu Ramboiu

19 April 2025

Background/Objectives: Groin hernia repair is a common surgical procedure worldwide, with increasing adoption of minimally invasive techniques. However, the adoption of laparoscopic repair varies significantly across healthcare systems. This study ai...

  • Review
  • Open Access
20 Citations
10,424 Views
28 Pages

Cardiovascular–Kidney–Metabolic Syndrome: A New Paradigm in Clinical Medicine or Going Back to Basics?

  • Victoria Mutruc,
  • Cristina Bologa,
  • Victorița Șorodoc,
  • Alexandr Ceasovschih,
  • Bianca Codrina Morărașu,
  • Laurențiu Șorodoc,
  • Oana Elena Catar and
  • Cătălina Lionte

19 April 2025

Cardiovascular, renal, and metabolic diseases are pathophysiologically interdependent, posing a significant global health challenge and being associated with a substantial increase in morbidity and mortality. In 2023, the American Heart Association (...

  • Review
  • Open Access
2 Citations
1,188 Views
27 Pages

19 April 2025

Background: Chronic disease self-management (CDSM) interventions have shown promise in improving patient outcomes in heart failure (HF), particularly for those with reduced ejection fraction (HFrEF). Patient-centric self-management programs often inc...

  • Article
  • Open Access
2 Citations
2,403 Views
13 Pages

Impact of the 2023 ACR/EULAR Antiphospholipid Syndrome Criteria on Retinal Vein Occlusion Patients

  • Rafael Gálvez-Sánchez,
  • Zaida Salmón González,
  • Magdalena Fernández-García,
  • Andrea Cerveró Varona,
  • Belén González-Mesones,
  • Marcos López-Hoyos,
  • Víctor Martínez-Taboada and
  • José Luis Hernández

19 April 2025

Background/Objectives: Retinal vein occlusion (RVO) represents a common ophthalmological disorder that, if untreated, often leads to severely impaired vision. The classic vascular risk factors, aging and glaucoma, represent the core pathogenic factor...

  • Article
  • Open Access
2,399 Views
10 Pages

Predictive Risk Factors for Low Anterior Resection Syndrome (LARS) in Rectal Cancer—An Observational Cohort Study

  • Sorinel Lunca,
  • Stefan Morarasu,
  • Constantin Osman,
  • Fadi Al Shatarat,
  • Tudor Gramada,
  • Mara Razniceanu,
  • Monica Buzemurga,
  • Emanuel Baltig,
  • Raluca Zaharia and
  • Wee Liam Ong
  • + 1 author

19 April 2025

Background/Objectives: The improved long-term survival of rectal cancer patients has led to a major increase in the prevalence of functional complications. Understanding which patients are prone to develop major LARS is important for their preoperati...

  • Article
  • Open Access
1 Citations
5,249 Views
18 Pages

The Effects of Joint Mobilization and Myofascial Release on Muscle Thickness in Non-Specific Low Back Pain: A Randomized Clinical Trial

  • Hafiz Muhammad Waseem Javaid,
  • Syed Shakil Ur Rehman,
  • Muhammad Kashif,
  • Muhammad Salman Bashir and
  • Wajeeha Zia

19 April 2025

Background: Non-specific low back pain is a discomfort that affects individuals at any point in their lives. This study’s aim was to determine the effects of myofascial release and joint mobilization on muscle thickness via ultrasonography in individ...

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J. Clin. Med. - ISSN 2077-0383