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Journal of Clinical Medicine, Volume 14, Issue 8

April-2 2025 - 323 articles

Cover Story: Metastatic hormone-sensitive prostate cancer (mHSPCa) may present de novo or as significant disease progression and typically requires systemic treatment. Recently, triplet therapy—integrating ADT, docetaxel, and an ARSI—has emerged as an effective approach, particularly in high-volume metastatic disease, as supported by ARASENS and PEACE-1. Advances in imaging, such as PSMA PET-CT, have improved disease detection, allowing for earlier detection of metastasis and timely initiation of appropriate therapy. Genomic profiling has enabled the development of biomarker-driven, personalized treatment strategies. As novel therapies, targeted agents, and immunotherapies undergo investigation, optimizing treatment selection based on disease burden, molecular characteristics, and patient factors will be essential. View this paper
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Articles (323)

  • Article
  • Open Access
1 Citations
1,771 Views
17 Pages

Management Concepts of Bisphosphonate-Related Atypical Femoral Fractures

  • Liviu-Coriolan Misca,
  • Rehan Gul and
  • Jenel Marian Patrascu

21 April 2025

Background/Objectives: Osteoporosis is an important health issue worldwide, and bisphosphonates are commonly prescribed for its treatment. However, certain complications can occur with long-term bisphosphonate therapy. The complication highlighted in...

  • Article
  • Open Access
2 Citations
1,161 Views
13 Pages

Endothelial Activation and Stress Index—A Novel and Simple Prognostic Tool in Coronary Artery Bypass Grafting

  • Philipp Krombholz-Reindl,
  • Andreas Vötsch,
  • Klaus Linni,
  • Rainald Seitelberger,
  • Roman Gottardi,
  • Michael Lichtenauer,
  • Matthias Hammerer,
  • Elke Boxhammer and
  • Andreas Winkler

21 April 2025

Objectives: Risk stratification in coronary artery bypass grafting (CABG) remains challenging despite existing models. The Endothelial Activation and Stress Index (EASIX), originally developed for hematological conditions, has shown promise in variou...

  • Article
  • Open Access
2,130 Views
13 Pages

Coflex Interspinous Stabilization with Decompression for Lumbar Spinal Stenosis: An Average 14-Year Follow-Up

  • Juneyoung Heo,
  • Ji-Hoon Baek,
  • Ji Hyun Kim,
  • Jae Chil Chang,
  • Hyung-ki Park and
  • Su Chan Lee

21 April 2025

Background: This study aimed to evaluate the long-term clinical usefulness and radiologic changes around the Coflex device following decompression with Coflex insertion for degenerative lumbar spinal stenosis (DLSS), with an average follow-up of 14 y...

  • Article
  • Open Access
6 Citations
2,507 Views
19 Pages

21 April 2025

Background: It is a well-established fact that late-life depression represents a significant public health issue, particularly in low- and middle-income countries experiencing rapid demographic aging. Although its clinical and societal impacts are we...

  • Article
  • Open Access
3 Citations
1,234 Views
22 Pages

Prognostic Value of the Red Cell Distribution Width-to-eGFR Ratio (RGR) Across Chronic Heart Failure Phenotypes: A Retrospective Observational Pilot Study

  • Andreea Varga,
  • Liviu Cristescu,
  • Marius-Stefan Marusteri,
  • Razvan Gheorghita Mares,
  • Dragos-Gabriel Iancu,
  • Radu Adrian Suteu,
  • Raluca-Maria Tilinca and
  • Ioan Tilea

21 April 2025

Background/Objectives: This study aimed to investigate the prognostic value of the red cell distribution width-to-estimated glomerular filtration rate (RGR) ratio in patients hospitalized with chronic heart failure (CHF) and its potential interaction...

  • Article
  • Open Access
2 Citations
1,762 Views
11 Pages

Hospitalization Predictors in Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Post Hoc Study of a Multicentric Retrospective Analysis

  • Grgur Salai,
  • Tatjana Tokić Vukan-Ćusa,
  • Mirna Vergles,
  • Sanda Škrinjarić Cincar,
  • Jelena Ostojić,
  • Matea Škoro,
  • Žarko Vrbica,
  • Emilija Lozo Vukovac,
  • Neven Tudorić and
  • Andrea Vukić Dugac

21 April 2025

Background/Objectives: Hospitalizations for acute exacerbations in patients with chronic obstructive pulmonary disease (AECOPD) are connected with considerable mortality and morbidity and have a great impact on healthcare costs. We aimed to identify...

  • Review
  • Open Access
5 Citations
6,475 Views
12 Pages

Drug-Coated Balloon Treatment for Urethral Strictures: Is This the Future? A Review of the Current Literature

  • Konstantinos Kapriniotis,
  • Ioannis Loufopoulos,
  • Aikaterini Apostolopoulou,
  • Paul C. B. Anderson and
  • Efstathios Papaefstathiou

21 April 2025

Urethral strictures significantly impact patients’ quality of life, with endoscopic treatments such as direct vision internal urethrotomy (DVIU) and dilatation showing high recurrence rates. Drug-coated balloon (DCB) treatment, which delivers p...

  • Review
  • Open Access
13 Citations
8,493 Views
24 Pages

21 April 2025

The endocannabinoid system is a complex communication system involved in maintaining homeostasis in various physiological processes, including metabolism, immune response, pain modulation, and neuroprotection. Endocannabinoids, mainly anandamide and...

  • Review
  • Open Access
1 Citations
2,528 Views
19 Pages

Multimodal Imaging of Immune Checkpoint Inhibitor Myocarditis

  • Shreyans Patel,
  • Kartikeya Dave,
  • Mario J. Garcia,
  • Carlos A. Gongora,
  • Mark I. Travin and
  • Lili Zhang

21 April 2025

Immune checkpoint inhibitors (ICIs) have dramatically changed the landscape of cancer treatment and are increasingly used either as monotherapy or in combination with other ICIs, chemotherapy, and molecularly targeted agents. ICI myocarditis is a rar...

  • Article
  • Open Access
1,183 Views
17 Pages

21 April 2025

Background/Objectives: Chronic macular edema (CME) is a common complication of diabetic retinopathy or non-infectious uveitis affecting the posterior segment (NIU-PS). Alongside anti-VEGF therapy, glucocorticoids are frequently used to manage CME. Gi...

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J. Clin. Med. - ISSN 2077-0383