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Journal of Clinical Medicine, Volume 14, Issue 8

April-2 2025 - 323 articles

Cover Story: Metastatic hormone-sensitive prostate cancer (mHSPCa) may present de novo or as significant disease progression and typically requires systemic treatment. Recently, triplet therapy—integrating ADT, docetaxel, and an ARSI—has emerged as an effective approach, particularly in high-volume metastatic disease, as supported by ARASENS and PEACE-1. Advances in imaging, such as PSMA PET-CT, have improved disease detection, allowing for earlier detection of metastasis and timely initiation of appropriate therapy. Genomic profiling has enabled the development of biomarker-driven, personalized treatment strategies. As novel therapies, targeted agents, and immunotherapies undergo investigation, optimizing treatment selection based on disease burden, molecular characteristics, and patient factors will be essential. View this paper
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Articles (323)

  • Article
  • Open Access
2,520 Views
12 Pages

The Risk Factors for Post-Bronchoscopy Respiratory Infection in Lung Cancer Patients—A Retrospective Case–Control Study from a Center in Greece

  • Vasileios Papavasileiou,
  • Thomas Raptakis,
  • Georgios Lavasidis,
  • Georgios Niotis,
  • Katerina Papavasileiou,
  • Stefanos Lampadakis,
  • Vasiliki Athanasopoulou,
  • Pavlos Siozos,
  • Kalliopi Theoni Vandorou and
  • Garyfallia Nizami
  • + 2 authors

21 April 2025

Introduction: Flexible bronchoscopy and its new methods have revolutionized the era of the diagnosis, staging, and restaging of lung cancer. A rare late complication is post-bronchoscopy respiratory infection, but it is critical due to treatment dela...

  • Article
  • Open Access
5 Citations
2,034 Views
20 Pages

Glycemic Control, Inflammatory Mediators, and Periodontal Health: A Cross-Sectional Study in Patients with Diabetes

  • Vanessa Bolchis,
  • Daniela Jumanca,
  • Ramona Dumitrescu,
  • Octavia Balean,
  • Nicoleta A. Toderas,
  • Simona Popescu,
  • Anca Marcu,
  • Catalin Marian and
  • Atena Galuscan

21 April 2025

Background/Objectives: The bidirectional relationship between diabetes mellitus (DM) and periodontal disease (PD) has garnered increasing attention due to shared inflammatory mechanisms and mutual disease exacerbation. In Romania, despite a high prev...

  • Systematic Review
  • Open Access
7 Citations
1,905 Views
32 Pages

21 April 2025

Background/Objectives: Air pollution is the highest environmental risk factor of mortality and morbidity worldwide, leading to over 4 million deaths each year. Among different air pollutants, ultrafine particles (UFPs) constitute the highest risk fac...

  • Reply
  • Open Access
1 Citations
558 Views
2 Pages
  • Review
  • Open Access
2 Citations
1,732 Views
14 Pages

Utilization of Platelet-Rich Plasma in Oral Surgery: A Systematic Review of the Literature

  • Andrea Giannelli,
  • Marta Forte,
  • Giuseppe D’Albis,
  • Giulia Cianciotta,
  • Luisa Limongelli,
  • Laura Stef,
  • Ramona Feier,
  • Abdulrahman Omar Alrashadah,
  • Massimo Corsalini and
  • Saverio Capodiferro

20 April 2025

Introduction: The physiological process of wound healing is a complex and dynamic series of events that aims to restore damaged tissues to their original structure and function. Platelet-rich plasma (PRP), an autologous blood-derived product, is char...

  • Systematic Review
  • Open Access
1 Citations
2,571 Views
21 Pages

Efficacy of Radiofrequency by the Topaz Technique for Chronic Plantar Fasciopathy: Systematic Review and Meta-Analysis

  • Sandra Domingo-Marques,
  • Eduardo Nieto-García,
  • Nadia Fernández-Erhling,
  • Leonor Ramírez-Andrés,
  • Juan Vicente-Mampel and
  • Javier Ferrer-Torregrosa

20 April 2025

Background/Objectives: Chronic plantar fasciopathy is a degenerative pathology that elicits persistent heel pain, significantly impacting quality of life. When conservative treatments fail to yield satisfactory outcomes, radiofrequency microtenotomy...

  • Article
  • Open Access
1 Citations
1,138 Views
9 Pages

Synovial Glucose and Serum-to-Synovial Glucose Predict Failure After Acute Postoperative Infection in Total Knee Arthroplasty

  • Marta Sabater-Martos,
  • Laia Boadas,
  • Laura Morata,
  • Alex Soriano and
  • Juan Carlos Martínez-Pastor

20 April 2025

Background: The treatment of periprosthetic joint infection (PJI) involves various strategies, with debridement, antibiotic, and implant retention (DAIR) being a preferred method for acute infections due to its lower morbidity. However, DAIR success...

  • Article
  • Open Access
3 Citations
2,253 Views
20 Pages

Role of MRI in the Diagnosis of Ductal Carcinoma In Situ: A Retrospective Study

  • Cristina García Ruiz,
  • Laila Zitan Saidi,
  • Lucía Zambrana Aguilar,
  • Maricela Moreira Cabrera,
  • Carolina Carvia Ponsaille,
  • Rosa Vázquez Sousa,
  • Carmen Martínez Porras and
  • Antonio Fernando Murillo-Cancho

20 April 2025

Background: The use of dynamic magnetic resonance imaging (MRI) for the evaluation, detection, and characterization of ductal carcinoma in situ (DCIS) has been increasing; however, its application in this context remains controversial and uncertain....

  • Article
  • Open Access
1 Citations
1,682 Views
13 Pages

20 April 2025

Background: Foreign body airway obstruction is a sudden emergency that can occur unexpectedly in healthy people, leading to severe consequences if immediate first aid is not provided. Unlike the Heimlich maneuver for adults, the first aid for infant...

  • Article
  • Open Access
2 Citations
1,127 Views
13 Pages

The Role of the Cerebellum in Multiple Sclerosis-Related Fatigue and Disability

  • Nicola Manocchio,
  • Ornella Argento,
  • Michela Bossa,
  • Barbara Spanò,
  • Leonardo Pellicciari,
  • Calogero Foti and
  • Ugo Nocentini

20 April 2025

Background: Fatigue is a prevalent and debilitating symptom in people with multiple sclerosis (pwMS), significantly impairing quality of life. While the cerebellum is traditionally associated with motor control, emerging evidence suggests its involve...

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J. Clin. Med. - ISSN 2077-0383