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Journal of Clinical Medicine, Volume 12, Issue 9

May-1 2023 - 303 articles

Cover Story: Head and neck (HN) squamous cell carcinomas (SCCs) originate from the epithelial cells of the mucosal linings of the upper aerodigestive tract, which includes the oral cavity, the pharynx, the larynx, and the sinonasal cavities. Human papilloma virus (HPV) is another independent risk factor for oropharyngeal SCC, but it is only a minor contributor to oral cavity SCC (OSCC). Betel quid chewing is also an established risk factor in southeast Asian countries. However, OSCC, and especially oral tongue cancer, incidence has been reported to be increasing in several countries, suggesting risk factors that have not been identified yet. This review summarizes the established risk factors for oral cavity squamous cell carcinomas and examines other undemonstrated risk factors for HNSCC. View this paper
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Articles (303)

  • Review
  • Open Access
37 Citations
29,939 Views
16 Pages

The Pain Management of Trauma Patients in the Emergency Department

  • Andrea Fabbri,
  • Antonio Voza,
  • Alessandro Riccardi,
  • Sossio Serra and
  • Fabio De Iaco

The vast majority of injured patients suffer from pain. Systematic assessment of pain on admission to the emergency department (ED) is a cornerstone of translating the best treatment strategies for patient care into practice. Pain must be measured wi...

  • Article
  • Open Access
4 Citations
2,223 Views
9 Pages

Metrics of Gender Differences in Mortality Risk after Diabetic Foot Disease

  • Giuseppe Seghieri,
  • Elisa Gualdani,
  • Piergiorgio Francia,
  • Ilaria Campesi,
  • Flavia Franconi,
  • Graziano Di Cianni and
  • Paolo Francesconi

Background: The aim of this study was to clarify any gender differences in the mortality risk of people with DFD since patients with diabetic foot disease (DFD) are at a high risk of mortality and, at the same time, are more likely to be men. Methods...

  • Review
  • Open Access
10 Citations
6,110 Views
12 Pages

Overview of Spontaneous Intracranial Hypotension and Differential Diagnosis with Chiari I Malformation

  • Wan Muhammad Nazief Bin Wan Hassan,
  • Francesco Mistretta,
  • Stefano Molinaro,
  • Riccardo Russo,
  • Giovanni Bosco,
  • Andrea Gambino and
  • Mauro Bergui

Spontaneous intracranial hypotension (SIH) occurs due to a leakage of the cerebrospinal fluid (CSF) lowering the pressure of subarachnoid space, mostly caused by a dural breach or discogenic microspur. As a result of less support provided by CSF pres...

  • Article
  • Open Access
4 Citations
3,921 Views
12 Pages

Development and Temporal Validation of an Electronic Medical Record-Based Insomnia Prediction Model Using Data from a Statewide Health Information Exchange

  • Emma Holler,
  • Farid Chekani,
  • Jizhou Ai,
  • Weilin Meng,
  • Rezaul Karim Khandker,
  • Zina Ben Miled,
  • Arthur Owora,
  • Paul Dexter,
  • Noll Campbell and
  • Craig Solid
  • + 1 author

This study aimed to develop and temporally validate an electronic medical record (EMR)-based insomnia prediction model. In this nested case-control study, we analyzed EMR data from 2011–2018 obtained from a statewide health information exchange...

  • Case Report
  • Open Access
5 Citations
3,463 Views
8 Pages

A Case Report of Pediatric Patient with Tuberous Sclerosis and Radiologically Isolated Syndrome

  • Giorgia Sforza,
  • Gabriele Monte,
  • Alessandra Voci,
  • Lorenzo Figà Talamanca,
  • Laura Papetti,
  • Michela Ada Noris Ferilli,
  • Martina Proietti Checchi,
  • Massimiliano Valeriani and
  • Romina Moavero

Introduction: Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disease with central nervous system (CNS) involvement. Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the CNS characterized by symptoma...

  • Article
  • Open Access
3 Citations
7,857 Views
12 Pages

Impact of Invasive Pulmonary Aspergillosis in Critically Ill Surgical Patients with or without Solid Organ Transplantation

  • Simon Dubler,
  • Michael Etringer,
  • Markus A. Weigand,
  • Thorsten Brenner,
  • Stefan Zimmermann,
  • Paul Schnitzler,
  • Bettina Budeus,
  • Fabian Rengier,
  • Paulina Kalinowska and
  • Yuan Lih Hoo
  • + 1 author

Background: Critically ill patients, especially those who have undergone solid organ transplantation (SOT), are at risk of invasive pulmonary aspergillosis (IPA). The outcome relevance of adequately treated putative IPA (pIPA) is a matter of debate....

  • Systematic Review
  • Open Access
11 Citations
3,447 Views
19 Pages

Role of Fibroblasts in Chronic Inflammatory Signalling in Chronic Rhinosinusitis with Nasal Polyps—A Systematic Review

  • José Palacios-García,
  • Cristina Porras-González,
  • Ramón Moreno-Luna,
  • Juan Maza-Solano,
  • Juan Polo-Padillo,
  • José Luis Muñoz-Bravo and
  • Serafín Sánchez-Gómez

Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disease of the nose and paranasal sinuses characterized by the presence of nasal polyps. The symptoms produced by the presence of nasal polyps such as nasal obstruction, nasal disch...

  • Article
  • Open Access
3 Citations
3,479 Views
11 Pages

Red Flags for Chronic Inflammatory Demyelinating Polyradiculoneuropathy Associated with Sarcoidosis or Connective Tissue Diseases

  • Clément Vialatte de Pémille,
  • Nicolas Noël,
  • Clovis Adam,
  • Céline Labeyrie,
  • Adeline Not,
  • Guillemette Beaudonnet,
  • Andoni Echaniz-Laguna,
  • David Adams and
  • Cécile Cauquil

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare autoimmune disorder of the peripheral nervous system. Diagnosis relies on clinical and electrophysiological criteria. Various disorders requiring specific treatment regimens m...

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J. Clin. Med. - ISSN 2077-0383