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Journal of Clinical Medicine, Volume 12, Issue 9

2023 May-1 - 303 articles

Cover Story: Head and neck (HN) squamous cell carcinomas (SCCs) originate from the epithelial cells of the mucosal linings of the upper aerodigestive tract, which includes the oral cavity, the pharynx, the larynx, and the sinonasal cavities. Human papilloma virus (HPV) is another independent risk factor for oropharyngeal SCC, but it is only a minor contributor to oral cavity SCC (OSCC). Betel quid chewing is also an established risk factor in southeast Asian countries. However, OSCC, and especially oral tongue cancer, incidence has been reported to be increasing in several countries, suggesting risk factors that have not been identified yet. This review summarizes the established risk factors for oral cavity squamous cell carcinomas and examines other undemonstrated risk factors for HNSCC. View this paper
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Articles (303)

  • Article
  • Open Access
19 Citations
10,597 Views
18 Pages

Prevalence, Severity of Extension, and Risk Factors of Gingivitis in a 3-Month Pregnant Population: A Multicenter Cross-Sectional Study

  • Jocelyne Gare,
  • Aida Kanoute,
  • Giovanna Orsini,
  • Lucio Souza Gonçalves,
  • Fahad Ali Alshehri,
  • Denis Bourgeois and
  • Florence Carrouel

The scope of this study was to assess the prevalence, severity of extension, and risk factors of gingivitis among pregnant women. In this cross-sectional study, 220 nulliparous women at 3 months of pregnancy were recruited in 2022 at the first obstet...

(This article belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
  • Review
  • Open Access
18 Citations
6,821 Views
12 Pages

Treat-to-Target in Systemic Lupus Erythematosus: Reality or Pipe Dream

  • Dina Zucchi,
  • Chiara Cardelli,
  • Elena Elefante,
  • Chiara Tani and
  • Marta Mosca

Treat-to-target is a therapeutic approach based on adjustments to treatment at set intervals in order to achieve well-defined, clinically relevant targets. This approach has been successfully applied to many chronic conditions, and in rheumatology pr...

(This article belongs to the Special Issue Lupus and Scleroderma: New Aspects and Considerations)
  • Article
  • Open Access
11 Citations
3,426 Views
11 Pages

Hospitalisation Due to Community-Acquired Acute Kidney Injury and the Role of Medications: A Retrospective Audit

  • Henna Duong,
  • Wubshet Tesfaye,
  • Connie Van,
  • Kamal Sud and
  • Ronald L. Castelino

The aim of this study is to assess the use of high-risk medications in patients with community-acquired acute kidney injury (CA-AKI) and the differences in the characteristics and outcomes of CA-AKI based on the use of these medications. This is a re...

(This article belongs to the Section Pharmacology)
  • Article
  • Open Access
2 Citations
2,888 Views
9 Pages

Clinical Analysis of Repeat Penetrating Keratoplasty in Children

  • Yajie Sun,
  • Qi Lin,
  • Peng Song,
  • Xu Li and
  • Zhiqiang Pan

(1) Background: To analyze the indications, graft survival, and graft failure-related risk factors of repeat penetrating keratoplasty (RPK) in children. (2) Methods: In this case series, children younger than 12 years who received RPK at Beijing Tong...

(This article belongs to the Section Ophthalmology)
  • Article
  • Open Access
7 Citations
3,203 Views
15 Pages

Hospital Memories and Six-Month Psychological Outcome: A Prospective Study in Critical Ill Patients with COVID-19 Respiratory Failure

  • Matteo Pozzi,
  • Claudio Ripa,
  • Valeria Meroni,
  • Daniela Ferlicca,
  • Alice Annoni,
  • Marta Villa,
  • Maria Grazia Strepparava,
  • Emanuele Rezoagli,
  • Simone Piva and
  • the Monza Follow-Up Study Group
  • + 3 authors

ICU survivors suffer from various long-term physical and psychological impairments. Memories from the critical illness may influence long-term psychological outcome. In particular, the role of ICU memories in COVID-19 critically ill patients is unkno...

(This article belongs to the Section Respiratory Medicine)
  • Systematic Review
  • Open Access
44 Citations
18,864 Views
20 Pages

Treatment Modalities for Internet Addiction in Children and Adolescents: A Systematic Review of Randomized Controlled Trials (RCTs)

  • Shahana Ayub,
  • Lakshit Jain,
  • Shanli Parnia,
  • Anil Bachu,
  • Rabeea Farhan,
  • Harendra Kumar,
  • Amanda Sullivan and
  • Saeed Ahmed

Background: In recent years, the use of the internet among children and adolescents has dramatically increased, leading to growing concerns regarding the potential risks of excessive internet use and addiction. Addressing these concerns, this systema...

(This article belongs to the Special Issue Substance and Behavioral Addictions: Updates on Etiology and Clinical Interventions)
  • Article
  • Open Access
2 Citations
2,798 Views
14 Pages

The Gastropack Access System as a Model to Access Gastroenterology Services for Gastroscopy Appropriateness in Patients with Upper Gastrointestinal Symptoms: A Comparison with the Open Access System

  • Liza Ceroni,
  • Francesca Lodato,
  • Paolo Tubertini,
  • Giovanni Marasco,
  • Alessia Gazzola,
  • Maurizio Biselli,
  • Cristiano Fabbri,
  • Federica Buonfiglioli,
  • Francesco Ferrara and
  • on behalf of Gastropack System Study Group
  • + 14 authors

Esophagogastroduodenoscopy (EGD) appropriateness in Open-Access System (OAS) is a relevant issue. The Gastropack Access System (GAS) is a new system to access gastroenterological services, based on the partnership between Gastroenterologists and GPs....

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
9 Citations
2,897 Views
12 Pages

Role of Lung Ultrasound in the Follow-Up of Children with Previous SARS-CoV-2 Infection: A Case-Control Assessment of Children with Long COVID or Fully Recovered

  • Danilo Buonsenso,
  • Rosa Morello,
  • Francesco Mariani,
  • Cristina De Rose,
  • Rossella Cortese,
  • Luigi Vetrugno and
  • Piero Valentini

Lung ultrasound (LUS) can detect lower respiratory tract involvement in children with acute SARS-CoV-2 infection. However, its role in follow-up assessments is still unclear. To describe LUS findings in children after SARS-CoV-2 infection, we conduct...

(This article belongs to the Section Clinical Pediatrics)
  • Review
  • Open Access
21 Citations
6,267 Views
21 Pages

Obesity, Preserved Ejection Fraction Heart Failure, and Left Ventricular Remodeling

  • Jason Stencel,
  • Hamid R. Alai,
  • Aneesh Dhore-patil,
  • Daniela Urina-Jassir and
  • Thierry H. Le Jemtel

Owing to the overwhelming obesity epidemic, preserved ejection fraction heart failure commonly ensues in patients with severe obesity and the obese phenotype of preserved ejection fraction heart failure is now commonplace in clinical practice. Severe...

(This article belongs to the Section Cardiovascular Medicine)
  • Review
  • Open Access
32 Citations
16,555 Views
16 Pages

Corticosteroids in ARDS

  • Emmanuelle Kuperminc,
  • Nicholas Heming,
  • Miguel Carlos and
  • Djillali Annane

Acute respiratory distress syndrome (ARDS) is frequently associated with sepsis. ARDS and sepsis exhibit a common pathobiology, namely excessive inflammation. Corticosteroids are powerful anti-inflammatory agents that are routinely used in septic sho...

(This article belongs to the Special Issue New Insights into Acute Respiratory Distress Syndrome)
  • Article
  • Open Access
2 Citations
2,486 Views
9 Pages

Association of the Calcification Score of the Abdominal Aorta, Common Iliac, and Renal Arteries with Outcomes in Living Kidney Donors

  • Luís Costa Ribeiro,
  • Manuela Almeida,
  • Jorge Malheiro,
  • Filipa Silva,
  • Diogo Nunes-Carneiro,
  • La Salete Martins,
  • Sofia Pedroso and
  • Miguel Silva-Ramos

Background: Vascular calcification is an ever-more-common finding in protocoled pre-transplant imaging in living kidney donors. We intended to explore whether a connection could be found between the Agatston calcification score, prior to kidney donat...

(This article belongs to the Special Issue Recent Advances of Kidney Transplantation)
  • Brief Report
  • Open Access
4 Citations
2,440 Views
9 Pages

A Trend towards Diaphragmatic Muscle Waste after Invasive Mechanical Ventilation in Multiple Trauma Patients—What to Expect?

  • Liliana Mirea,
  • Cristian Cobilinschi,
  • Raluca Ungureanu,
  • Ana-Maria Cotae,
  • Raluca Darie,
  • Radu Tincu,
  • Oana Avram,
  • Sorin Constantinescu,
  • Costin Minoiu and
  • Ioana Marina Grintescu
  • + 1 author

Considering the prioritization of life-threatening injuries in trauma care, secondary dysfunctions such as ventilator-induced diaphragmatic dysfunction (VIDD) are often overlooked. VIDD is an entity induced by muscle inactivity during invasive mechan...

(This article belongs to the Special Issue Key Advances in the Treatment of the Critically Ill)
  • Review
  • Open Access
20 Citations
7,437 Views
19 Pages

Utility of MRI in Quantifying Tissue Injury in Cervical Spondylotic Myelopathy

  • Ali Fahim Khan,
  • Grace Haynes,
  • Esmaeil Mohammadi,
  • Fauziyya Muhammad,
  • Sanaa Hameed and
  • Zachary A. Smith

Cervical spondylotic myelopathy (CSM) is a progressive disease that worsens over time if untreated. However, the rate of progression can vary among individuals and may be influenced by various factors, such as the age of the patients, underlying cond...

(This article belongs to the Special Issue Latest Developments in Minimally Invasive Spinal Treatment)
  • Article
  • Open Access
33 Citations
6,083 Views
11 Pages

Smoking Increases the Risk of Hepatocellular Carcinoma and Cardiovascular Disease in Patients with Metabolic-Associated Fatty Liver Disease

  • Jeong-Ju Yoo,
  • Man Young Park,
  • Eun Ju Cho,
  • Su Jong Yu,
  • Sang Gyune Kim,
  • Yoon Jun Kim,
  • Young Seok Kim and
  • Jung-Hwan Yoon

The association of smoking with hepatocellular carcinoma (HCC) or cardiovascular disease (CVD) has been reported, but the study of its relationship with metabolic-associated fatty liver disease (MAFLD) is limited. We aimed to investigate the effect o...

(This article belongs to the Section Cardiovascular Medicine)
  • Article
  • Open Access
3 Citations
4,983 Views
10 Pages

The Liver Can Deliver: Utility of Hepatic Function Tests as Predictors of Outcome in COVID-19, Influenza and RSV Infections

  • Einat Ritter,
  • Eden Shusterman,
  • Lior Prozan,
  • Orli Kehat,
  • Ahuva Weiss Meilik,
  • Oren Shibolet and
  • Jacob Nadav Ablin

Background: liver test abnormalities have been described in patients with Coronavirus-2019 (COVID-19), and hepatic involvement may correlate with disease severity. With the relaxing of COVID-19 restrictions, seasonal respiratory viruses now circulate...

(This article belongs to the Special Issue Clinical Impact of COVID-19 on Liver Diseases)
  • Article
  • Open Access
5 Citations
4,083 Views
13 Pages

Efficacy and Safety of Chemotherapy in Elderly Patients with Unresectable Pancreatic Cancer

  • Byung Soo Kwan,
  • Ok Jae Lee,
  • Hyun Jin Kim,
  • Kwang Min Kim,
  • Sang Goon Shim,
  • Dae Hyeon Cho,
  • Sung Min Kong,
  • Jun Young Kim and
  • Jun Ho Ji

Background/Aims: The incidence of pancreatic cancer (PC) is gradually increasing among elderly individuals, but there are insufficient clinical data on elderly individuals. To determine the efficacy and safety of chemotherapy, we compared the. the ou...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
4 Citations
3,070 Views
11 Pages

Quantitative Assessment of Upper Limb Movement in Post-Stroke Adults for Identification of Sensitive Measures in Reaching and Lifting Activities

  • Monika Błaszczyszyn,
  • Agnieszka Szczęsna,
  • Mariusz Konieczny,
  • Paweł Pakosz,
  • Stefan Balko and
  • Zbigniew Borysiuk

Background: The assumption of this work is the achievement of objective results of the movement structure, which forms the basis for in-depth analysis and, consequently, for determining the upper limb movements that are most affected by stroke compar...

(This article belongs to the Section Clinical Rehabilitation)
  • Article
  • Open Access
24 Citations
3,895 Views
11 Pages

The Presence of Myosteatosis Is Associated with Age, Severity of Liver Disease and Poor Outcome and May Represent a Prodromal Phase of Sarcopenia in Patients with Liver Cirrhosis

  • Eleni Geladari,
  • Theodoros Alexopoulos,
  • Meropi D. Kontogianni,
  • Larisa Vasilieva,
  • Iliana Mani,
  • Roxane Tenta,
  • Vasilios Sevastianos,
  • Ioannis Vlachogiannakos and
  • Alexandra Alexopoulou

Background/Aims: Myosteatosis implies impaired muscle quality. The aim of the study was to investigate the association of myosteatosis with other muscle abnormalities and its role in the prognosis of liver cirrhosis (LC). Method: Skeletal muscle inde...

(This article belongs to the Special Issue Established and Novel Approaches for Sarcopenia)
  • Article
  • Open Access
14 Citations
4,650 Views
11 Pages

The potential effects of asymptomatic flexible flatfoot (FF) on children’s health-related quality of life (QoL) and objective clinical foot characteristics have been poorly investigated in the literature. Therefore, this study aimed to analyse...

(This article belongs to the Topic Children’s Diseases, Family Management, and Quality of Life)
  • Article
  • Open Access
2 Citations
2,535 Views
11 Pages

Value of Fractional Exhaled Nitric Oxide in Diagnosing Mild Asthma Responsive to Inhaled Corticosteroids

  • Natasa Karamarkovic Lazarusic,
  • Eugenija Kasap Basioli,
  • Ena Tolic,
  • Martina Dokoza and
  • Gordana Pavlisa

Background: Mild asthma is often characterized by normal spirometric values and a negative bronchodilation test (BDT), which makes accurate diagnosis challenging. The aim of our study was to evaluate the diagnostic accuracy of fractional exhaled nitr...

(This article belongs to the Section Respiratory Medicine)
  • Brief Report
  • Open Access
7 Citations
4,334 Views
8 Pages

Maternal intrapartum fever can lead to various maternal and neonatal complications and is attributed to various etiologies including infectious and non-infectious processes. In this study, we evaluated whether intrapartum fever affects the offspring&...

(This article belongs to the Section Obstetrics & Gynecology)
  • Review
  • Open Access
25 Citations
8,188 Views
18 Pages

Choice of the Dialysis Modality: Practical Considerations

  • Massimo Torreggiani,
  • Giorgina Barbara Piccoli,
  • Maria Rita Moio,
  • Ferruccio Conte,
  • Lorenza Magagnoli,
  • Paola Ciceri and
  • Mario Cozzolino

Chronic kidney disease and the need for kidney replacement therapy have increased dramatically in recent decades. Forecasts for the coming years predict an even greater increase, especially in low- and middle-income countries, due to the rise in meta...

(This article belongs to the Section Nephrology & Urology)
  • Article
  • Open Access
7 Citations
5,233 Views
13 Pages

Background: Postoperative bleeding requiring re-exploration in cardiac surgery has been associated with complications impacting short-term outcomes and perioperative survival. Many aspects of decision-making for re-exploration still remain controvers...

(This article belongs to the Section Cardiovascular Medicine)
  • Review
  • Open Access
21 Citations
6,574 Views
15 Pages

Injectable Platelet-Rich Fibrin (I-PRF) Administered to Temporomandibular Joint Cavities: A Scoping Review

  • Marcin Sielski,
  • Kamila Chęcińska,
  • Maciej Chęciński and
  • Maciej Sikora

The aim of this review was to systematically map the research on the intra-articular administration of injectable platelet-rich fibrin (I-PRF) to the temporomandibular joints (TMJs). Medical databases covered by the ACM, BASE, Google, NLM, and Resear...

(This article belongs to the Special Issue Updates and Challenges in Maxillo-Facial Surgery)
  • Review
  • Open Access
5 Citations
3,919 Views
11 Pages

Evolution of Concepts: Can Personalized Hip Arthroplasty Improve Joint Stability?

  • Sivan Sivaloganathan,
  • William G. Blakeney,
  • Charles Rivière and
  • Pascal-André Vendittoli

Hip arthroplasty procedures are successful and reproducible. However, within the first two post-operative years, hip dislocations are the most common cause for revisions. This is despite the majority of the dislocations having the acetabular componen...

(This article belongs to the Section Orthopedics)
  • Review
  • Open Access
13 Citations
6,109 Views
21 Pages

Since its emergence as a diagnostic modality in the 1980s, endoscopic ultrasound (EUS) has provided the clinician profound access to gastrointestinal organs to aid in the direct visualization, sampling, and subsequent identification of pancreatic pat...

(This article belongs to the Special Issue Endoscopic Ultrasound-Guided Diagnosis and Treatment of Gastrointestinal Diseases)
  • Systematic Review
  • Open Access
32 Citations
7,422 Views
16 Pages

(1) Background: There is still disagreement over how sleeve gastrectomy (SG) affects gastroesophageal reflux disease (GERD). The debate regarding the best option for patients undergoing bariatric surgery who are also affected by GERD and/or hiatal he...

(This article belongs to the Special Issue Clinical Updates on Bariatric Surgery)
  • Review
  • Open Access
53 Citations
15,442 Views
22 Pages

Diagnosis and Management of Malnutrition in Patients with Heart Failure

  • Alberto Esteban-Fernández,
  • Rocío Villar-Taibo,
  • Mirian Alejo,
  • David Arroyo,
  • Juan Luis Bonilla Palomas,
  • Montserrat Cachero,
  • Clara Joaquin,
  • Manuel Méndez Bailón,
  • José Ángel Pérez-Rivera and
  • Gema Somoza
  • + 1 author

Heart failure is a disease with an increasingly greater prevalence due to the aging population, the development of new drugs, and the organization of healthcare processes. Malnutrition has been identified as a poor prognostic factor in these patients...

(This article belongs to the Section Cardiovascular Medicine)
  • Brief Report
  • Open Access
3 Citations
3,127 Views
7 Pages

Tinnitus Is Marginally Associated with Body Mass Index, Heart Rate and Arterial Blood Pressure: Results from a Large Clinical Sample

  • Berthold Langguth,
  • Jan Bulla,
  • Beate Fischer,
  • Hansjoerg Baurecht,
  • Martin Schecklmann,
  • Steven C. Marcrum and
  • Veronika Vielsmeier

Introduction: This study aimed to explore whether body mass index (BMI), systolic blood pressure (RR syst), diastolic blood pressure (RR diast) or heart rate (HR) are associated with tinnitus status and/or severity. Methods: To that end, we evaluated...

(This article belongs to the Topic Brain, Hearing and Tinnitus Science)
  • Article
  • Open Access
8 Citations
2,352 Views
9 Pages

We previously published that insulin pump initiation immediately after IV insulin therapy was associated with improved post-surgical glycemic outcomes compared to multiple daily injections (MDI) in pediatric patients following a total pancreatectomy...

(This article belongs to the Section Endocrinology & Metabolism)
  • Article
  • Open Access
3 Citations
2,956 Views
15 Pages

Single Center, Propensity Score Matching Analysis of Different Reconstruction Techniques following Pancreatoduodenectomy

  • Ruben Bellotti,
  • Benno Cardini,
  • Carola J. Strolz,
  • Stefan Stättner,
  • Rupert Oberhuber,
  • Eva Braunwarth,
  • Thomas Resch,
  • Stefan Scheidl,
  • Christian Margreiter and
  • Manuel Maglione
  • + 2 authors

Background: Pancreatoduodenectomy is still hampered by significant morbidity. So far, there is no universally accepted technique aimed at minimizing postoperative complications. Herein, we compare three different reconstruction techniques. Methods: T...

(This article belongs to the Section General Surgery)
  • Brief Report
  • Open Access
11 Citations
3,919 Views
6 Pages

Ureteral complications such as urinary leak, ureteral necrosis or ureteral stenosis are common complications after renal transplantation with major short- and long-term issues, including graft impairment and graft loss. At present, there is no agreem...

(This article belongs to the Special Issue Recent Advances of Kidney Transplantation)
  • Review
  • Open Access
8 Citations
3,960 Views
15 Pages

Functional Mitral and Tricuspid Regurgitation across the Whole Spectrum of Left Ventricular Ejection Fraction: Recognizing the Elephant in the Room of Heart Failure

  • Valeria Cammalleri,
  • Giorgio Antonelli,
  • Valeria Maria De Luca,
  • Myriam Carpenito,
  • Annunziata Nusca,
  • Maria Caterina Bono,
  • Simona Mega,
  • Gian Paolo Ussia and
  • Francesco Grigioni

Functional mitral regurgitation (FMR) and tricuspid regurgitation (FTR) occur due to cardiac remodeling in the presence of structurally normal valve apparatus. Two main mechanisms are involved, distinguishing an atrial functional form (when annulus d...

(This article belongs to the Special Issue New Advances in Pharmacologic and Non-pharmacologic Therapy in Heart Failure and Heart Transplant)
  • Editorial
  • Open Access
13 Citations
3,030 Views
4 Pages

In clinical mental health practice, the presence of Dual Disorders (DDs), defined as the comorbidity of at least one Substance Use Disorder (SUD) and another mental disorder in the same person [...]

(This article belongs to the Special Issue Recent Advances in Dual Disorders (Addiction and Other Mental Disorders))
  • Article
  • Open Access
4 Citations
3,616 Views
13 Pages

Ventilatory Effects of Isoflurane Sedation via the Sedaconda ACD-S versus ACD-L: A Substudy of a Randomized Trial

  • Lukas M. Müller-Wirtz,
  • Tobias Becher,
  • Ulf Günther,
  • Martin Bellgardt,
  • Peter Sackey,
  • Thomas Volk and
  • Andreas Meiser

Devices used to deliver inhaled sedation increase dead space ventilation. We therefore compared ventilatory effects among isoflurane sedation via the Sedaconda ACD-S (internal volume: 50 mL), isoflurane sedation via the Sedaconda ACD-L (100 mL), and...

(This article belongs to the Section Emergency Medicine)
  • Article
  • Open Access
5 Citations
2,524 Views
11 Pages

Reconstruction of Hand and Foot Defects with Free Serratus Carpaccio Flap and Free Serratus Fascia Flap: A Comparative Retrospective Study of Surgical Outcomes

  • Jia Wei Tee,
  • Amir K. Bigdeli,
  • Benjamin Thomas,
  • Florian Falkner,
  • Oliver Didzun,
  • Felix H. Vollbach,
  • Ulrich Kneser and
  • Emre Gazyakan

Background: Defects of the hand and foot often require an individualized reconstructive approach, due to their unique functional and aesthetic characteristics. Transferred tissues should be thin, pliable, and durable, with free fascial flaps meeting...

(This article belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
  • Article
  • Open Access
25 Citations
4,149 Views
11 Pages

Elevated Neutrophil-to-Lymphocyte Ratio Is Associated with Severe Asthma Exacerbation in Children

  • Noga Arwas,
  • Sharon Uzan Shvartzman,
  • Aviv Goldbart,
  • Romi Bari,
  • Itai Hazan,
  • Amir Horev and
  • Inbal Golan Tripto

Asthma is the most common chronic respiratory disease in children. The neutrophil-to-lymphocyte ratio (NLR) is a marker of a chronic inflammatory state; however, data on the association of NLR with acute asthma exacerbations in children is lacking. I...

(This article belongs to the Special Issue New Insights into Pediatric Pulmonology)
  • Article
  • Open Access
3 Citations
2,722 Views
15 Pages

Plasma and Urinary Biomarkers Improve Prediction of Mortality through 1 Year in Intensive Care Patients: An Analysis from FROG-ICU

  • Beth A. Davison,
  • Christopher Edwards,
  • Gad Cotter,
  • Antoine Kimmoun,
  • Étienne Gayat,
  • Agnieszka Latosinska,
  • Harald Mischak,
  • Koji Takagi,
  • Benjamin Deniau and
  • Alexandre Mebazaa
  • + 1 author

Background: This study aimed to assess the value of blood and urine biomarkers in addition to routine clinical variables in risk stratification of patients admitted to ICU. Methods: Multivariable prognostic models were developed in this post hoc anal...

(This article belongs to the Topic Biomarker Development and Application)
  • Article
  • Open Access
22 Citations
13,280 Views
16 Pages

Effectiveness of a Manual Therapy Protocol in Women with Pelvic Pain Due to Endometriosis: A Randomized Clinical Trial

  • Elena Muñoz-Gómez,
  • Ana María Alcaraz-Martínez,
  • Sara Mollà-Casanova,
  • Núria Sempere-Rubio,
  • Marta Aguilar-Rodríguez,
  • Pilar Serra-Añó and
  • Marta Inglés

A randomized controlled trial was carried out to assess the effectiveness of a manual therapy protocol in terms of the clinical characteristics, quality of life, and emotional condition of the women with endometriosis-related pelvic pain. Forty-one w...

(This article belongs to the Topic Clinical Features and Intervention of Patients with Chronic Non-Oncologic Pain)
  • Article
  • Open Access
6 Citations
4,804 Views
9 Pages

Delayed Diagnosis of Congenital Myasthenic Syndromes Erroneously Interpreted as Mitochondrial Myopathies

  • Mariana I. Muñoz-García,
  • María Paz Guerrero-Molina,
  • Carlos Pablo de Fuenmayor-Fernández de la Hoz,
  • Laura Bermejo-Guerrero,
  • Ana Arteche-López,
  • Aurelio Hernández-Laín,
  • Miguel A. Martín and
  • Cristina Domínguez-González

Background: Congenital myasthenic syndromes (CMSs) and primary mitochondrial myopathies (PMMs) can present with ptosis, external ophthalmoplegia, and limb weakness. Methods: Our method involved the description of three cases of CMS that were initiall...

(This article belongs to the Special Issue Neuromuscular Disorders and Complications: In the Challenge Lies a Solution)
  • Review
  • Open Access
27 Citations
5,418 Views
20 Pages

Update on Pediatric Mild Traumatic Brain Injury in Rural and Underserved Regions: A Global Perspective

  • John K. Yue,
  • Nishanth Krishnan,
  • John P. Andrews,
  • Alexa M. Semonche,
  • Hansen Deng,
  • Alexander A. Aabedi,
  • Albert S. Wang,
  • David J. Caldwell,
  • Christine Park and
  • Peter P. Sun
  • + 3 authors

Background: Mild traumatic brain injury (MTBI) causes morbidity and disability worldwide. Pediatric patients are uniquely vulnerable due to developmental and psychosocial factors. Reduced healthcare access in rural/underserved communities impair mana...

(This article belongs to the Section Brain Injury)
  • Article
  • Open Access
2 Citations
3,816 Views
8 Pages

Accurate sonographic estimation of fetal weight is essential for every pregnancy, especially in twin gestation. We conducted a retrospective analysis of the sonographically estimated fetal weight (sEFW) of all twin gestations performed within 14 days...

(This article belongs to the Special Issue Clinical Diagnosis and Management of Pregnancy Complications)
  • Editorial
  • Open Access
2 Citations
2,573 Views
4 Pages

In the past, indications for total pancreatectomy (TP) were rare, with several concerns about patients’ postoperative quality of life due to exocrine and endocrine post-pancreatectomy management [...]

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Feature Paper
  • Review
  • Open Access
15 Citations
11,236 Views
13 Pages

Current fertility preservation options are limited for cancer survivor patients who wish to have their own biological children. Human in vitro gametogenesis (IVG) has the hypothetical ability to offer a unique solution to individuals receiving treatm...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
11 Citations
3,781 Views
13 Pages

Single-cell and single-population RNA sequencing (RNA-seq) is a rapidly evolving new field of intense investigation. Recent studies indicate unique transcriptomic profiles are derived based on the spatial localization of neurons within circuits and r...

(This article belongs to the Topic Applications of Biomedical Technology and Molecular Biological Approach in Brain Diseases)
  • Article
  • Open Access
11 Citations
3,491 Views
10 Pages

Narrow-band (NB) UVB and UVA1 have been successfully used for the treatment of atopic dermatitis (AD) since the 1980s, but the clinical indications for their use “at the age of biologics” remain to be assessed. From 2013 to 2017, 145 pati...

(This article belongs to the Special Issue Atopic Dermatitis: Research and Clinical Updates and Perspectives)
  • Article
  • Open Access
2 Citations
1,848 Views
12 Pages

Association of Renin-Angiotensin System Blockers with Survival in Patients on Maintenance Hemodialysis

  • Seok Hui Kang,
  • Bo Yeon Kim,
  • Eun Jung Son,
  • Gui Ok Kim and
  • Jun Young Do

Additional studies are needed to confirm whether the use of renin-angiotensin system blockers (RASBs) induces survival benefits in patients on hemodialysis (HD). This study aimed to evaluate patient survival with the use of RASBs in a large sample of...

(This article belongs to the Section Nephrology & Urology)
  • Review
  • Open Access
13 Citations
2,952 Views
20 Pages

Location and Gender Differences in Osteonecrosis of the Jaws in Patients Treated with Antiresorptive and Antineoplastic Drugs Undergoing Dentoalveolar Surgical, Systematic Review with Meta-Analysis and Trial Sequential Analysis

  • Mario Dioguardi,
  • Francesca Spirito,
  • Mario Alovisi,
  • Riccardo Aiuto,
  • Daniele Garcovich,
  • Vito Crincoli,
  • Andrea Ballini,
  • Giorgia Apollonia Caloro and
  • Lorenzo Lo Muzio

In the treatment and prevention of osteoporosis and more generally of neoplastic and metabolic pathologies affecting bone tissues, antiresorption drugs such as bisphosphonates and monoclonal antibody are used. Bisphosphonates have been linked to case...

(This article belongs to the Section Orthopedics)
  • Systematic Review
  • Open Access
16 Citations
4,329 Views
16 Pages

Association between Red Blood Cell Distribution Width and Obstructive Sleep Apnea Syndrome: A Systematic Review and Meta-Analysis

  • Biagio Di Lorenzo,
  • Maria Carmina Pau,
  • Elisabetta Zinellu,
  • Arduino A. Mangoni,
  • Panagiotis Paliogiannis,
  • Pietro Pirina,
  • Alessandro G. Fois,
  • Ciriaco Carru and
  • Angelo Zinellu

Although polysomnography is the gold standard method to diagnose obstructive sleep apnea syndrome (OSAS), there is an ongoing quest for simpler and relatively inexpensive biomarkers of disease presence and severity. To address this issue, we conducte...

(This article belongs to the Section Mental Health)

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J. Clin. Med. - ISSN 2077-0383