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Journal of Clinical Medicine, Volume 11, Issue 5

March-1 2022 - 317 articles

Cover Story: Paravalvular leak after mitral surgical replacement is frequent. Some of them, especially larger ones, can be clinically significant. Heart failure and hemolysis are the most prevalent clinical manifestations. Surgical reparation is considered the gold-standard therapy in current guidelines, but the percutaneous approach has emerged as an alternative. Transcatheter paravalvular leak closure has shown excellent results with a low rate of complications. Therefore, it is now considered the first option in selected patients in experienced centers. In this review, we summarize the clinical manifestations, diagnosis, procedural details, and results of transcatheter mitral paravalvular leak closure. View this paper 
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Articles (317)

  • Article
  • Open Access
21 Citations
4,801 Views
10 Pages

Hyperuricemia Is Associated with Significant Liver Fibrosis in Subjects with Nonalcoholic Fatty Liver Disease, but Not in Subjects without It

  • Pei-Chia Yen,
  • Yu-Tsung Chou,
  • Chung-Hao Li,
  • Zih-Jie Sun,
  • Chih-Hsing Wu,
  • Yin-Fan Chang,
  • Feng-Hwa Lu,
  • Yi-Ching Yang,
  • Chih-Jen Chang and
  • Jin-Shang Wu

7 March 2022

Liver fibrosis is associated with liver-related outcomes, yet often remains underdiagnosed in primary care settings. Hyperuricemia is associated with non-alcoholic fatty liver disease (NAFLD), but the relationship between hyperuricemia and liver fibr...

  • Article
  • Open Access
13 Citations
4,253 Views
8 Pages

6 March 2022

Aim: Currently, atezolizumab combined with bevacizumab is the standard first-line treatment for unresectable hepatocellular carcinoma (HCC), but lenvatinib or sorafenib are still recommended for these patients for some reasons. The aim of the study w...

  • Article
  • Open Access
7 Citations
3,002 Views
9 Pages

6 March 2022

Central serous chorioretinopathy (CSCR) can be complicated by different types of choroidal neovascularization (CNV). The purpose of this study was to investigate the incidence and quantitative optical coherence tomography angiography (OCT-A) features...

  • Systematic Review
  • Open Access
14 Citations
3,879 Views
12 Pages

How Is Spinal Cord Function Measured in Degenerative Cervical Myelopathy? A Systematic Review

  • Khadija H. Soufi,
  • Tess M. Perez,
  • Alexis O. Umoye,
  • Jamie Yang,
  • Maria Burgos and
  • Allan R. Martin

5 March 2022

Degenerative cervical myelopathy (DCM) is a prevalent condition in which spinal degeneration causes cord compression and neurological dysfunction. The spinal cord is anatomically complex and operates in conjunction with the brain, the musculoskeletal...

  • Article
  • Open Access
2 Citations
3,354 Views
13 Pages

Clinical Characteristics of COVID-19 Patients and Application to an Artificial Intelligence System for Disease Surveillance

  • Ying-Chuan Wang,
  • Dung-Jang Tsai,
  • Li-Chen Yen,
  • Ya-Hsin Yao,
  • Tsung-Ta Chiang,
  • Chun-Hsiang Chiu,
  • Te-Yu Lin,
  • Kuo-Ming Yeh and
  • Feng-Yee Chang

5 March 2022

During the coronavirus disease (COVID-19) pandemic, we admitted suspected or confirmed COVID-19 patients to our isolation wards between 2 March 2020 and 4 May 2020, following a well-designed and efficient assessment protocol. We included 217 patients...

  • Article
  • Open Access
5 Citations
4,507 Views
15 Pages

A Computational Text Mining-Guided Meta-Analysis Approach to Identify Potential Xerostomia Drug Targets

  • Micaela F. Beckman,
  • Elizabeth J. Brennan,
  • Chika K. Igba,
  • Michael T. Brennan,
  • Farah B. Mougeot and
  • Jean-Luc C. Mougeot

5 March 2022

Xerostomia (subjective complaint of dry mouth) is commonly associated with salivary gland hypofunction. Molecular mechanisms associated with xerostomia pathobiology are poorly understood, thus hampering drug development. Our objectives were to (i) us...

  • Article
  • Open Access
8 Citations
4,108 Views
13 Pages

Expression of Macrophage Scavenger Receptor (MSR1) in Peripheral Blood Cells from Patients with Different Respiratory Diseases: Beyond Monocytes

  • Selene Baos,
  • Lucía Cremades-Jimeno,
  • María López-Ramos,
  • María Ángeles de Pedro,
  • Silvia A. Uriarte,
  • Joaquín Sastre,
  • Nicolás González-Mangado,
  • María Jesús Rodríguez-Nieto,
  • Germán Peces-Barba and
  • Blanca Cárdaba

5 March 2022

Background: Macrophage scavenger receptor 1 (MSR1) has mostly been described in macrophages, but we previously found a significant gene expression increase in peripheral blood mononuclear cells (PBMCs) of asthmatic patients. Objective: To confirm tho...

  • Article
  • Open Access
7 Citations
3,298 Views
9 Pages

A Retrospective Study of Postictal Suppression during Electroconvulsive Therapy

  • Virginie Moulier,
  • Julien Guehl,
  • Emilie Evêque-Mourroux,
  • Pierre Quesada and
  • Maud Rothärmel

5 March 2022

Background: electroconvulsive therapy (ECT) is the most effective treatment in treatment-resistant depression (TRD), but its response remains partial. Identifying useful indicators to guide decision making for treatment and improve clinical response...

  • Article
  • Open Access
3 Citations
2,707 Views
7 Pages

Elective Neck Dissection during Salvage Total Laryngectomy: Personal Experience

  • Jacopo Galli,
  • Giovanni Di Cintio,
  • Stefano Settimi,
  • Antonio Salvati,
  • Claudio Parrilla,
  • Giovanni Almadori and
  • Gaetano Paludetti

5 March 2022

The role of elective neck dissection during salvage surgery in patients with a clinically negative neck (cN0) is still discussed. The main objective of this work was to estimate the prevalence and predictive factors of occult neck nodes metastasis; w...

  • Article
  • Open Access
11 Citations
3,507 Views
11 Pages

Accuracy of a Computer-Aided Dynamic Navigation System in the Placement of Zygomatic Dental Implants: An In Vitro Study

  • Juan Ramón González Rueda,
  • Irene García Ávila,
  • Víctor Manuel de Paz Hermoso,
  • Elena Riad Deglow,
  • Álvaro Zubizarreta-Macho,
  • Jesús Pato Mourelo,
  • Javier Montero Martín and
  • Sofía Hernández Montero

5 March 2022

The objective of this in vitro study was to evaluate and compare the accuracy of zygomatic dental implant (ZI) placement carried out using a dynamic navigation system. Materials and Methods: Forty (40) ZIs were randomly distributed into one of two st...

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J. Clin. Med. - ISSN 2077-0383