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Journal of Clinical Medicine, Volume 10, Issue 4

February-2 2021 - 339 articles

Cover Story: The clot-stabilizing effect and downstream functionalities of coagulation factor XIII (FXIII) make it a promising target for drug development since FXIII inhibition does not significantly increase the bleeding risk. To investigate the inhibitory effect of aptamers on activated FXIII (FXIIIa), six DNA aptamers targeting FXIIIa were selected and characterized. Among all, the so-called FA12 aptamer showed inhibitoy effect on incorporation of FXIIIa and α2-antiplasmin (α2AP) to fibrin. Furthermore, FA12 reduced the clot stiffness and elasticity in ROTEM analysis when spiked to citrated plasma or whole blood. These features render FA12 as an interesting candidate molecule for the development of FXIIIa-targeting therapeutic strategies. View this paper
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Articles (339)

  • Article
  • Open Access
12 Citations
3,774 Views
15 Pages

22 February 2021

Chronic low back pain (CLBP) is often without clear underlying pathology. Affective disturbance and dysfunctional pain mechanisms, commonly observed in populations with CLBP, have, therefore, been suggested as potential contributors to CLBP developme...

  • Article
  • Open Access
16 Citations
3,664 Views
13 Pages

Cigarette Smoking, miR-27b Downregulation, and Peripheral Artery Disease: Insights into the Mechanisms of Smoking Toxicity

  • Tiago Pereira-da-Silva,
  • Patrícia Napoleão,
  • Marina C. Costa,
  • André F. Gabriel,
  • Mafalda Selas,
  • Filipa Silva,
  • Francisco J. Enguita,
  • Rui Cruz Ferreira and
  • Miguel Mota Carmo

22 February 2021

Cigarette smoking is a risk factor for the development of peripheral artery disease (PAD), although the proatherosclerotic mediators of cigarette smoking are not entirely known. We explored whether circulating microRNAs (miRNAs) are dysregulated in c...

  • Article
  • Open Access
4 Citations
3,321 Views
16 Pages

Quantification of Bacteria in Mouth-Rinsing Solution for the Diagnosis of Periodontal Disease

  • Jeong-Hwa Kim,
  • Jae-Woon Oh,
  • Young Lee,
  • Jeong-Ho Yun,
  • Seong-Ho Choi and
  • Dong-Woon Lee

22 February 2021

This study aimed to evaluate the feasibility of diagnosing periodontitis via the identification of 18 bacterial species in mouth-rinse samples. Patients (n = 110) who underwent dental examinations in the Department of Periodontology at the Veterans H...

  • Article
  • Open Access
35 Citations
3,865 Views
9 Pages

Effects of the COVID-19 Epidemic on Hospital Admissions for Non-Communicable Diseases in a Large Italian University-Hospital: A Descriptive Case-Series Study

  • Caterina Caminiti,
  • Giuseppe Maglietta,
  • Tiziana Meschi,
  • Andrea Ticinesi,
  • Mario Silva and
  • Nicola Sverzellati

21 February 2021

Background: Concern is growing about the negative consequences that response measures to the COVID-19 epidemic may have on the management of other medical conditions. Methods: A retrospective descriptive case-series study conducted at a large Univers...

  • Review
  • Open Access
14 Citations
3,083 Views
15 Pages

Prognostic Significance of Survivin Expression in Patients with Ovarian Carcinoma: A Meta-Analysis

  • Beata Gąsowska-Bajger,
  • Agnieszka Gąsowska-Bodnar,
  • Paweł Knapp and
  • Lubomir Bodnar

21 February 2021

Background: Survivin belongs to the protein family of inhibitors of apoptosis (IAP) and is a regulator of the cell cycle and apoptosis. The aim of this study was to assess the clinical and prognostic significance of expression survivin in patients wi...

  • Article
  • Open Access
9 Citations
4,111 Views
11 Pages

Secondary Hemophagocytic Lymphohistiocytosis and Autoimmune Cytopenias: Case Description and Review of the Literature

  • Bruno Fattizzo,
  • Marta Ferraresi,
  • Juri Alessandro Giannotta and
  • Wilma Barcellini

20 February 2021

Hemophagocytic lymphohistocytosis (HLH) is a rare hyperinflammatory condition which may be primary or secondary to many diseases, including hematologic malignancies. Due to its life-threatening evolution, a timely diagnosis is paramount but challengi...

  • Review
  • Open Access
75 Citations
11,770 Views
21 Pages

Immunological Risk Factors in Recurrent Pregnancy Loss: Guidelines Versus Current State of the Art

  • Kilian Vomstein,
  • Katharina Feil,
  • Laura Strobel,
  • Anna Aulitzky,
  • Susanne Hofer-Tollinger,
  • Ruben-Jeremias Kuon and
  • Bettina Toth

20 February 2021

Around 1–5% of all couples experience recurrent pregnancy loss (RPL). Established risk factors include anatomical, genetic, endocrine, and hemostatic alterations. With around 50% of idiopathic cases, immunological risk factors are getting into the sc...

  • Article
  • Open Access
2 Citations
2,859 Views
9 Pages

20 February 2021

Transfusion reactions are mainly induced by the interaction of an antigen and antibody. However, transfusion reactions still occur with the implementing of crossmatching and usage of pre-storage leukoreduced blood products. The roles of CD28 and CTLA...

  • Communication
  • Open Access
11 Citations
5,213 Views
8 Pages

20 February 2021

Background: The number of people surviving critical illness is rising rapidly around the globe. Survivorship comes at a cost, with approximately half of patients with acute respiratory failure (ARF) experiencing clinically significant symptoms of anx...

  • Article
  • Open Access
3 Citations
3,096 Views
9 Pages

Is Neoadjuvant Treatment Justified in Clinical T1 Pancreatic Ductal Adenocarcinoma?

  • Hyung Sun Kim,
  • Kenji Nakagawa,
  • Takahiro Akahori,
  • Kota Nakamura,
  • Tadataka Takagi,
  • Masayuki Sho,
  • Joon Seong Park and
  • Dong Sup Yoon

20 February 2021

Introduction: Studies on neoadjuvant treatment have been actively conducted in patients with resectable pancreatic cancer. However, neoadjuvant treatment effectiveness, especially in clinical T1 stage patients, still needs to be determined. We compar...

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J. Clin. Med. - ISSN 2077-0383