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Vaccines, Volume 10, Issue 5
May 2022 - 196 articles
Cover Story: The SARS-CoV-2 pandemic is combated with a third vaccination. Considering initially different vaccination regimens, we addressed whether previous vaccinations influence the immune response to the booster. Healthcare workers that received either two doses of BNT162b2 or a priming dose of ChAdOx1-nCoV-19 followed by a BNT162b2 dose were recruited and vaccinated with a third dose of BNT162b2. Initially significant differences in the antibody concentrations rapidly aligned. The same was the case for initially age-dependent differences in the anti-S concentrations. The measured T cell responses did not show any differences depending on the vaccination regimen. The results imply that a third vaccination dose elicits comparable immune responses in differentially immunized individuals, which is of major importance for healthcare policy makers. View this paper
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Vaccines - ISSN 2076-393XCreative Common CC BY license