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Vaccines, Volume 9, Issue 11

2021 November - 164 articles

Cover Story: Dual vaccines were developed against two debilitating cattle viruses, lumpy skin disease virus (LSDV) and bovine ephemeral fever virus (BEFV). Because the infections are seasonal and sporadic, vaccine uptake is poor. A single vaccine targeting the two viruses would be cost effective and improve vaccine coverage against both viruses, which co-localize geographically, largely in Africa. Two modified LSDV backbones were tested, both as vaccine (against LSDV) and vector (for BEFV). The BEFV glycoprotein and matrix genes were inserted into the LSDV backbones, and the candidate vaccines were tested in cattle. After two vaccinations, all animals elicited both neutralizing and binding antibodies against BEFV. All vaccinated animals developed both neutralizing and T cell responses against LSDV and were protected against virulent LSDV challenge. View this paper
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Articles (164)

  • Article
  • Open Access
21 Citations
5,359 Views
12 Pages

22 November 2021

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) created a global pandemic (COVID-19) that has resulted in massive health and economic losses. The current unavailability of treatments leaves vaccination as the only way to control this dis...

  • Article
  • Open Access
6 Citations
3,794 Views
9 Pages

22 November 2021

Vaccines are widely employed in aquaculture to prevent bacterial infections, but their use by the U.S. catfish industry is very limited. One of the main diseases affecting catfish aquaculture is columnaris disease, caused by the bacterial pathogen Fl...

  • Article
  • Open Access
25 Citations
5,114 Views
13 Pages

The African Swine Fever Virus with MGF360 and MGF505 Deleted Reduces the Apoptosis of Porcine Alveolar Macrophages by Inhibiting the NF-κB Signaling Pathway and Interleukin-1β

  • Qi Gao,
  • Yunlong Yang,
  • Weipeng Quan,
  • Jiachen Zheng,
  • Yizhuo Luo,
  • Heng Wang,
  • Xiongnan Chen,
  • Zhao Huang,
  • Xiaojun Chen and
  • Lang Gong
  • + 2 authors

22 November 2021

African swine fever virus (ASFV) poses serious threats to the swine industry. The mortality rate of African swine fever (ASF) is 100%, and there is no effective vaccine currently available. Complex immune escape strategies of ASFV are crucial factors...

  • Article
  • Open Access
11 Citations
4,016 Views
11 Pages

Patients’ Perception and Knowledge about Influenza and Pneumococcal Vaccination during the COVID-19 Pandemic: An Online Survey in Patients at Risk of Infections

  • Paul Loubet,
  • Jalini Rouvière,
  • Adeline Merceron,
  • Odile Launay,
  • Albert Sotto and
  • on behalf of the AVNIR Group

22 November 2021

Introduction: The objective of our study was to assess, in an at-risk population, perception and knowledge about influenza and pneumococcal vaccinations. Methods: An anonymous web-based survey was submitted to patients recruited in France, from both...

  • Article
  • Open Access
27 Citations
4,989 Views
19 Pages

Development of a Candidate Multi-Epitope Subunit Vaccine against Klebsiella aerogenes: Subtractive Proteomics and Immuno-Informatics Approach

  • Ahitsham Umar,
  • Asma Haque,
  • Youssef Saeed Alghamdi,
  • Mutaib M Mashraqi,
  • Abdur Rehman,
  • Farah Shahid,
  • Mohsin Khurshid and
  • Usman Ali Ashfaq

22 November 2021

Klebsiella aerogenes is a Gram-negative bacterium which has gained considerable importance in recent years. It is involved in 10% of nosocomial and community-acquired urinary tract infections and 12% of hospital-acquired pneumonia. This organism has...

  • Article
  • Open Access
6 Citations
4,222 Views
13 Pages

Regional Differences in COVID-19 Vaccine Hesitancy in December 2020: A Natural Experiment in the French Working-Age Population

  • Fanny Velardo,
  • Verity Watson,
  • Pierre Arwidson,
  • François Alla,
  • Stéphane Luchini,
  • Michaël Schwarzinger and
  • CoVaMax Study Group

20 November 2021

It can be assumed that higher SARS-CoV-2 infection risk is associated with higher COVID-19 vaccination intentions, although evidence is scarce. In this large and representative survey of 6007 adults aged 18–64 years and residing in France, 8.1%...

  • Article
  • Open Access
18 Citations
6,125 Views
12 Pages

20 November 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the current COVID-19 pandemic, has caused more than 4.5 million deaths worldwide. Severe and fatal cases of COVID-19 are often associated with increased proinflammat...

  • Article
  • Open Access
17 Citations
21,292 Views
12 Pages

20 November 2021

This study verifies whether there is a strong correlation between the pro-vaccination, against COVID-19 attitude of the respondents and their belief that most of those around them want to be vaccinated against COVID-19. For this purpose, we analyzed...

  • Article
  • Open Access
17 Citations
10,905 Views
15 Pages

20 November 2021

We intended to assess the humoral response induced by the Pfizer/BioNTech Comirnaty COVID-19 vaccine with commercially available immunoassays: anti-spike (S) IgG and IgM, and anti-nucleocapsid (N) IgG antibodies, over a 4-month course. One hundred su...

  • Article
  • Open Access
6 Citations
4,796 Views
17 Pages

The Cost-Effectiveness of 13-Valent Pneumococcal Conjugate Vaccine in Seven Chinese Cities

  • Yan Li,
  • Huaqing Wang,
  • Wesley Furnback,
  • Bruce C. M. Wang,
  • Shuiqing Zhu and
  • Peng Dong

20 November 2021

Objective: This study estimates the cost-effectiveness of vaccination with the 13-valent pneumococcal conjugate vaccine (PCV13) among infants in Beijing, Shanghai, Shenzhen, Chengdu, Karamay, Qingdao, and Suzhou. Methods: A previously published cost-...

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Vaccines - ISSN 2076-393X