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Vaccines, Volume 7, Issue 1

March 2019 - 33 articles

Cover Story: African swine fever virus (ASFV) causes high morbidity and mortality in swine and its recent spread into Western Europe and China highlights the urgent need to find a vaccine. Efficacy of vaccination with a DNA-protein cocktail of immunogenic ASFV antigens against virulent ASFV challenge with the Armenia 2007 strain in pigs was evaluated. Vaccinated animals had earlier onset of disease and death, and pathology tended to be more severe in vaccinees. A: Hemorrhagic lymphadenopathy, gastrohepatic lymph nodes (GHLN) with edema of the mesentery, common bile duct and gall bladder. B, C: Marked hemorrhage, edema and severe necrosis of lymphocytes (GHLN). These results indicate that a better understanding of detrimental immunopathological responses leading to ASFV pathology is important for the development of a safe and efficacious ASFV vaccine. View this paper

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Articles (33)

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Article

6 Citations

4,717 Views

10 Pages

Neonatal Genetic Delivery of Anti-Respiratory Syncytial Virus (RSV) Antibody by Non-Human Primate-Based Adenoviral Vector to Provide Protection against RSV

Rika Gomi,
Anurag Sharma,
Wenzhu Wu and
Stefan Worgall

Vaccines2019, 7(1), 3;https://doi.org/10.3390/vaccines7010003

29 December 2018

Respiratory syncytial virus (RSV) is one of the leading causes of lower respiratory tract infection in infants. Immunoprophylaxis with the anti-RSV monoclonal antibody, palivizumab, reduces the risk for RSV-related hospitalizations, but its use is re...

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Brief Report

14 Citations

4,714 Views

11 Pages

Attenuation and Stability of CHIKV-NoLS, a Live-Attenuated Chikungunya Virus Vaccine Candidate

Eranga Abeyratne,
Joseph R. Freitas,
Ali Zaid,
Suresh Mahalingam and
Adam Taylor

Vaccines2019, 7(1), 2;https://doi.org/10.3390/vaccines7010002

22 December 2018

Our previous investigation of the nucleolar localisation sequence (NoLS) of chikungunya virus (CHIKV) capsid protein demonstrated the role of capsid in CHIKV virulence. Mutating the NoLS of capsid in CHIKV led to the development of a unique live-atte...

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Opinion

3,656 Views

10 Pages

The Modified Vaccination Technique

Arpad Barabas,
Chad Cole,
Zoltan Kovacs,
Erno Kovacs and
Rene Lafreniere

Vaccines2019, 7(1), 1;https://doi.org/10.3390/vaccines7010001

21 December 2018

In addition to active and passive immunizations, there is a third method of immunization, the modified vaccination technique, which is based on injecting a combination of target antigens and antibodies against this antigen. The vaccine is essentially...

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Vaccines - ISSN 2076-393X

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