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Vaccines, Volume 13, Issue 1

January 2025 - 96 articles

Cover Story: Norovirus (NoV) protruding (P) domains that bind to receptors self-assemble into a 24-meric nanoparticle (P24 NP). By inserting the receptor-binding αTSR domain of the circumsporozoite protein of Plasmodium sporozoite into a surface loop of the P domain, we generated a self-assembling, chimeric P24-αTSR NP. The structural model, the P24-αTSR NP, was constructed, indicating that each P24-αTSR NP consists of a P24 NP core with 24 surface-exposed αTSR domains that retained authentic conformation and receptor binding function. The P24-αTSR NP elicited high antibody titers in mice toward both the NoV P domain and the αTSR domain of Plasmodium. The resulting antibodies bind to Plasmodium sporozoites and block NoV VLP binding to its receptors. Thus, the P24-αTSR NP may serve as a combination vaccine against both NoV and Plasmodium parasites. View this paper
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Articles (96)

  • Article
  • Open Access
3 Citations
6,022 Views
16 Pages

Impact of HPV Catch-Up Vaccination on High-Grade Cervical Lesions (CIN2+) Among Women Aged 26–30 in Northern Norway

  • Amanda Sørensen Jørgensen,
  • Gunnar Skov Simonsen and
  • Sveinung Wergeland Sørbye

20 January 2025

Background/Objectives: Human papillomavirus (HPV) is the primary cause of high-grade cervical lesions and cervical cancer worldwide. In Norway, HPV vaccination was introduced in 2009 for seventh-grade girls and extended through a catch-up program fro...

  • Article
  • Open Access
4 Citations
2,685 Views
19 Pages

Adenoviral Vector-Based Vaccine Expressing Hemagglutinin Stem Region with Autophagy-Inducing Peptide Confers Cross-Protection Against Group 1 and 2 Influenza A Viruses

  • Wen-Chien Wang,
  • Ekramy E. Sayedahmed,
  • Marwa Alhashimi,
  • Ahmed Elkashif,
  • Vivek Gairola,
  • Muralimanohara S. T. Murala,
  • Suryaprakash Sambhara and
  • Suresh K. Mittal

20 January 2025

Background/Objectives: An effective universal influenza vaccine is urgently needed to overcome the limitations of current seasonal influenza vaccines, which are ineffective against mismatched strains and unable to protect against pandemic influenza....

  • Article
  • Open Access
2 Citations
1,651 Views
21 Pages

20 January 2025

Background: Inefficient cellular uptake is a significant limitation to the efficacy of DNA vaccines. In this study, we introduce S-Cr9T, a stearyl-modified cell-penetrating peptide (CPP) designed to enhance DNA vaccine delivery by forming stable comp...

  • Article
  • Open Access
1 Citations
2,292 Views
13 Pages

Robust and Long-Lasting Immunity and Protection in Mice Induced by Lipopolyplex-Delivered mRNA Vaccines Expressing the Prefusion Protein of Respiratory Syncytial Virus

  • Xuchang Shan,
  • Ruiwen Han,
  • Xueting Cheng,
  • Jialuo Bing,
  • Zhenyong Qi,
  • Shucai Sun,
  • Tangqi Wang,
  • Qiaohong Chu,
  • Yao Deng and
  • Desheng Zhai
  • + 1 author

20 January 2025

Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in infants and children. mRNA vaccines based on the lipopolyplex (LPP) platform have been previously reported, but they remain unapplied in RSV vaccine devel...

  • Review
  • Open Access
4 Citations
10,866 Views
27 Pages

Advancing the Fight Against Cervical Cancer: The Promise of Therapeutic HPV Vaccines

  • Qian Zheng,
  • Misi He,
  • Zejia Mao,
  • Yue Huang,
  • Xiuying Li,
  • Ling Long,
  • Mingfang Guo and
  • Dongling Zou

19 January 2025

Human papillomavirus (HPV) is a major global health issue and is recognized as the leading cause of cervical cancer. While prophylactic vaccination programs have led to substantial reductions in both HPV infection rates and cervical cancer incidence,...

  • Article
  • Open Access
1 Citations
1,941 Views
15 Pages

A Study on the Induction of Multi-Type Immune Responses in Mice via an mRNA Vaccine Based on Hemagglutinin and Neuraminidase Antigen

  • Mengyuan Liu,
  • Yixuan Liu,
  • Shaohui Song,
  • Qiurong Qiao,
  • Jing Liu,
  • Yun Xie,
  • Jian Zhou and
  • Guoyang Liao

19 January 2025

Background: The Influenza A virus (IAV), a pathogen affecting the respiratory system, represents a major risk to public health worldwide. Immunization remains the foremost strategy to control the transmission of IAV. The virus has two primary antigen...

  • Article
  • Open Access
2 Citations
1,531 Views
27 Pages

Protective Efficacy of Decreasing Antigen Doses of a Chlamydia abortus Subcellular Vaccine Against Ovine Enzootic Abortion in a Pregnant Sheep Challenge Model

  • Morag Livingstone,
  • Kevin Aitchison,
  • Javier Palarea-Albaladejo,
  • Francesco Ciampi,
  • Clare Underwood,
  • Antonia Paladino,
  • Francesca Chianini,
  • Gary Entrican,
  • Sean Ranjan Wattegedera and
  • David Longbottom

18 January 2025

Background/Objective: Chlamydia abortus, the cause of ovine enzootic abortion, is a zoonotic bacterial pathogen and one of the most infectious causes of foetal death in sheep worldwide. Although the disease can be controlled using commercial inactiva...

  • Article
  • Open Access
1,733 Views
18 Pages

Antibody Responses to mRNA COVID-19 Vaccine Among Healthcare Workers in Outpatient Clinics in Japan

  • Teruhime Otoguro,
  • Keita Wagatsuma,
  • Toshiharu Hino,
  • The Society of Ambulatory and General Pediatrics of Japan,
  • Yusuke Ichikawa,
  • Tri Bayu Purnama,
  • Yuyang Sun,
  • Jiaming Li,
  • Irina Chon and
  • Hisami Watanabe
  • + 1 author

18 January 2025

Background: This study aimed to assess the antibody response to SARS-CoV-2 vaccines among healthcare workers (HCWs) from multiple outpatient clinics in Japan, examining the effects of baseline characteristics (e.g., sex, age, underlying condition, sm...

  • Article
  • Open Access
3,023 Views
14 Pages

18 January 2025

Background: Anthrax is a serious disease caused by Bacillus anthracis (B. anthracis) with a very high mortality when the spores of B. anthracis are inhaled (inhalational anthrax). Aerosolized B. anthracis spores can be used as a deadly bioweapon. Vac...

  • Conference Report
  • Open Access
2 Citations
1,635 Views
10 Pages

NIAID Workshop Report: Systematic Approaches for ESKAPE Bacteria Antigen Discovery

  • Inka Sastalla,
  • Keehwan Kwon,
  • Clayton Huntley,
  • Kimberly Taylor,
  • Liliana Brown,
  • Tamika Samuel and
  • Lanling Zou

18 January 2025

On 14–15 November 2023, the National Institute of Allergy and Infectious Diseases (NIAID) organized a workshop entitled “Systematic Approaches for ESKAPE Bacteria Antigen Discovery”. The goal of the workshop was to engage scientists...

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Vaccines - ISSN 2076-393X