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Antioxidants, Volume 9, Issue 11

November 2020 - 141 articles

Cover Story: Scarring is a major challenge in glaucoma surgery as it often causes surgical failure. We highlight the stimulatory effects of TGFβ1 on collagen synthesis in HTF that involve Nox4 signaling and promote ROS/H2O2 production. Collagen deposition at the surgical site of a mouse model of GFS is significantly reduced in Nox4-deficient (KO) animals. We illustrate a novel role of Nox4 in fibrotic response in HTFs and the development of postoperative scarring in a mouse model of GFS. View this paper
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Articles (141)

  • Article
  • Open Access
57 Citations
3,979 Views
17 Pages

Expression of Pro-Angiogenic Markers Is Enhanced by Blue Light in Human RPE Cells

  • Concetta Scimone,
  • Simona Alibrandi,
  • Sergio Zaccaria Scalinci,
  • Edoardo Trovato Battagliola,
  • Rosalia D’Angelo,
  • Antonina Sidoti and
  • Luigi Donato

20 November 2020

Inherited retinal dystrophies are characterized by photoreceptor death. Oxidative stress usually occurs, increasing vision loss, and oxidative damage is often reported in retinitis pigmentosa (RP). More than 300 genes have been reported as RP causing...

  • Article
  • Open Access
26 Citations
4,015 Views
17 Pages

20 November 2020

Physical activity has an influence on a variety of processes in an athlete’s organism including the immune system. Unfortunately, there is a lack of studies regarding racehorse immune cells, especially when the horse model is compared to human...

  • Review
  • Open Access
133 Citations
11,234 Views
21 Pages

20 November 2020

The benevolent and detrimental effects of antioxidants are much debated in clinical trials and cancer research. Several antioxidant enzymes and molecules are overexpressed in oxidative stress conditions that can damage cellular proteins, lipids, and...

  • Article
  • Open Access
44 Citations
9,149 Views
25 Pages

20 November 2020

Chronic inflammation is characterized by an overproduction of several inflammatory mediators (e.g., reactive species and interleukins -IL) that play a central role in numerous diseases. The available therapies are often associated with serious side e...

  • Article
  • Open Access
48 Citations
4,369 Views
24 Pages

Possible A2E Mutagenic Effects on RPE Mitochondrial DNA from Innovative RNA-Seq Bioinformatics Pipeline

  • Luigi Donato,
  • Concetta Scimone,
  • Simona Alibrandi,
  • Alessandro Pitruzzella,
  • Federica Scalia,
  • Rosalia D’Angelo and
  • Antonina Sidoti

20 November 2020

Mitochondria are subject to continuous oxidative stress stimuli that, over time, can impair their genome and lead to several pathologies, like retinal degenerations. Our main purpose was the identification of mtDNA variants that might be induced by i...

  • Article
  • Open Access
14 Citations
3,048 Views
12 Pages

20 November 2020

Few studies have reported on changes to oxidative stress and mitochondrial DNA copy numbers in patients with Parkinson’s disease (PD), particularly those undergoing long-term dopamine therapy. This study measured mitochondrial copy numbers, thi...

  • Article
  • Open Access
99 Citations
6,568 Views
18 Pages

19 November 2020

Carbon dots (CDs) due to their unique optical features, chemical stability and low environmental hazard are applied in different fields such as metal ion sensing, photo-catalysis, bio-imaging and tribology, among others. The aims of the present resea...

  • Article
  • Open Access
27 Citations
3,924 Views
10 Pages

Antioxidant Activity and Acteoside Analysis of Abeliophyllum distichum

  • Hak-Dong Lee,
  • Ji Hyun Kim,
  • Qi Qi Pang,
  • Pil-Mun Jung,
  • Eun Ju Cho and
  • Sanghyun Lee

19 November 2020

This study determined acteoside and its content in Abeliophyllum distichum via HPLC/UV and LC/ESI-MS to obtain insights into the potential use of this plant as an antioxidant agent. Moreover, 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl (•OH),...

  • Article
  • Open Access
61 Citations
8,600 Views
14 Pages

Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities, Molecular Docking, and Antioxidant Capacities of Salvia aurita Constituents

  • Ninon G. E. R. Etsassala,
  • Jelili A. Badmus,
  • Jeanine L. Marnewick,
  • Emmanuel I. Iwuoha,
  • Felix Nchu and
  • Ahmed A. Hussein

19 November 2020

Diabetes mellitus (DM) is one of the most dangerous metabolic diseases with a high rate of mortality worldwide. It is well known that insulin resistance and deficiency in insulin production from pancreatic β-cells are the main characteristics of...

  • Review
  • Open Access
10 Citations
4,216 Views
21 Pages

Therapeutic Potential of Heme Oxygenase-1 in Aneurysmal Diseases

  • Wei-Cheng Jiang,
  • Chen-Mei Chen,
  • Candra D. Hamdin,
  • Alexander N. Orekhov,
  • Igor A. Sobenin,
  • Matthew D. Layne and
  • Shaw-Fang Yet

19 November 2020

Abdominal aortic aneurysm (AAA) and intracranial aneurysm (IA) are serious arterial diseases in the aorta and brain, respectively. AAA and IA are associated with old age in males and females, respectively, and if rupture occurs, they carry high morbi...

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Antioxidants - ISSN 2076-3921Creative Common CC BY license