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Review

Therapeutic Potential of Heme Oxygenase-1 in Aneurysmal Diseases

1
Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan 35053, Taiwan
2
Molecular and Biomedical Sciences, Department of Life Sciences, National Central University, Zhongli District, Taoyuan City 32001, Taiwan
3
Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, Russia
4
Laboratory of Medical Genetics, National Medical Research Center of Cardiology, 15A 3-rd Cherepkovskaya Street, 121552 Moscow, Russia
5
Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
*
Author to whom correspondence should be addressed.
Equal contribution.
Antioxidants 2020, 9(11), 1150; https://doi.org/10.3390/antiox9111150
Received: 17 October 2020 / Revised: 16 November 2020 / Accepted: 17 November 2020 / Published: 19 November 2020
(This article belongs to the Special Issue Pharmacological and Clinical Significance of Heme Oxygenase-1)
Abdominal aortic aneurysm (AAA) and intracranial aneurysm (IA) are serious arterial diseases in the aorta and brain, respectively. AAA and IA are associated with old age in males and females, respectively, and if rupture occurs, they carry high morbidity and mortality. Aneurysmal subarachnoid hemorrhage (SAH) due to IA rupture has a high rate of complication and fatality. Despite these severe clinical outcomes, preventing or treating these devastating diseases remains an unmet medical need. Inflammation and oxidative stress are shared pathologies of these vascular diseases. Therefore, therapeutic strategies have focused on reducing inflammation and reactive oxygen species levels. Interestingly, in response to cellular stress, the inducible heme oxygenase-1 (HO-1) is highly upregulated and protects against tissue injury. HO-1 degrades the prooxidant heme and generates molecules with antioxidative and anti-inflammatory properties, resulting in decreased oxidative stress and inflammation. Therefore, increasing HO-1 activity is an attractive option for therapy. Several HO-1 inducers have been identified and tested in animal models for preventing or alleviating AAA, IA, and SAH. However, clinical trials have shown conflicting results. Further research and the development of highly selective HO-1 regulators may be needed to prevent the initiation and progression of AAA, IA, or SAH. View Full-Text
Keywords: abdominal aortic aneurysm; intracranial aneurysm; subarachnoid hemorrhage; heme oxygenase-1; inflammation; oxidative stress abdominal aortic aneurysm; intracranial aneurysm; subarachnoid hemorrhage; heme oxygenase-1; inflammation; oxidative stress
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MDPI and ACS Style

Jiang, W.-C.; Chen, C.-M.; Hamdin, C.D.; Orekhov, A.N.; Sobenin, I.A.; Layne, M.D.; Yet, S.-F. Therapeutic Potential of Heme Oxygenase-1 in Aneurysmal Diseases. Antioxidants 2020, 9, 1150. https://doi.org/10.3390/antiox9111150

AMA Style

Jiang W-C, Chen C-M, Hamdin CD, Orekhov AN, Sobenin IA, Layne MD, Yet S-F. Therapeutic Potential of Heme Oxygenase-1 in Aneurysmal Diseases. Antioxidants. 2020; 9(11):1150. https://doi.org/10.3390/antiox9111150

Chicago/Turabian Style

Jiang, Wei-Cheng, Chen-Mei Chen, Candra D. Hamdin, Alexander N. Orekhov, Igor A. Sobenin, Matthew D. Layne, and Shaw-Fang Yet. 2020. "Therapeutic Potential of Heme Oxygenase-1 in Aneurysmal Diseases" Antioxidants 9, no. 11: 1150. https://doi.org/10.3390/antiox9111150

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