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Antioxidants, Volume 9, Issue 11

November 2020 - 141 articles

Cover Story: Scarring is a major challenge in glaucoma surgery as it often causes surgical failure. We highlight the stimulatory effects of TGFβ1 on collagen synthesis in HTF that involve Nox4 signaling and promote ROS/H2O2 production. Collagen deposition at the surgical site of a mouse model of GFS is significantly reduced in Nox4-deficient (KO) animals. We illustrate a novel role of Nox4 in fibrotic response in HTFs and the development of postoperative scarring in a mouse model of GFS. View this paper
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Articles (141)

  • Feature Paper
  • Article
  • Open Access
15 Citations
4,277 Views
21 Pages

Extracellular Vesicles from SOD3-Transduced Stem Cells Exhibit Improved Immunomodulatory Abilities in the Murine Dermatitis Model

  • Ji Won Yang,
  • Yoojin Seo,
  • Tae-Hoon Shin,
  • Ji-Su Ahn,
  • Su-Jeong Oh,
  • Ye Young Shin,
  • Min-Jung Kang,
  • Byung-Chul Lee,
  • Seunghee Lee and
  • Kyung-Sun Kang
  • + 4 authors

23 November 2020

The immunoregulatory abilities of mesenchymal stem cells (MSCs) have been investigated in various autoimmune and allergic diseases. However, the therapeutic benefits observed in preclinical settings have not been reproducible in clinical trials. This...

  • Review
  • Open Access
55 Citations
11,153 Views
25 Pages

23 November 2020

Oxidative stress can be induced by various stimuli and altered in certain conditions, including exercise and pain. Although many studies have investigated oxidative stress in relation to either exercise or pain, the literature presents conflicting re...

  • Article
  • Open Access
10 Citations
3,686 Views
16 Pages

Inhibition of Osteoclast Differentiation by Carotenoid Derivatives through Inhibition of the NF-κB Pathway

  • Shlomit Odes-Barth,
  • Marina Khanin,
  • Karin Linnewiel-Hermoni,
  • Yifat Miller,
  • Karina Abramov,
  • Joseph Levy and
  • Yoav Sharoni

23 November 2020

The bone protective effects of carotenoids have been demonstrated in several studies, and the inhibition of RANKL-induced osteoclast differentiation by lycopene has also been demonstrated. We previously reported that carotenoid oxidation products are...

  • Article
  • Open Access
19 Citations
4,080 Views
14 Pages

23 November 2020

Cyclophosphamide (CP) was found to have a potential toxic effect on lung tissues. Raspberry ketones (RKs) are natural antioxidant chemicals isolated from red raspberries (Rubus ideaus). They are commonly used for weight loss and obesity. The current...

  • Article
  • Open Access
11 Citations
3,547 Views
14 Pages

Profiling of Low-Molecular-Weight Carbonyls and Protein Modifications in Flavored Milk

  • Michele Wölk,
  • Theres Schröter,
  • Ralf Hoffmann and
  • Sanja Milkovska-Stamenova

23 November 2020

Thermal treatments of dairy products favor oxidations, Maillard reactions, and the formation of sugar or lipid oxidation products. Additives including flavorings might enhance these reactions or even induce further reactions. Here we aimed to charact...

  • Feature Paper
  • Article
  • Open Access
23 Citations
4,205 Views
21 Pages

Polyphenolic and Methylxanthine Bioaccessibility of Cocoa Bean Shell Functional Biscuits: Metabolomics Approach and Intestinal Permeability through Caco-2 Cell Models

  • Olga Rojo-Poveda,
  • Letricia Barbosa-Pereira,
  • Charaf El Khattabi,
  • Estelle N.H. Youl,
  • Marta Bertolino,
  • Cédric Delporte,
  • Stéphanie Pochet and
  • Caroline Stévigny

22 November 2020

Cocoa bean shell (CBS), a by-product with considerable concentrations of bioactive compounds and proven biofunctional potential, has been demonstrated to be a suitable ingredient for high-fiber functional biscuits adapted to diabetic consumers. In th...

  • Article
  • Open Access
9 Citations
3,929 Views
15 Pages

Generation of Rat Monoclonal Antibody to Detect Hydrogen Sulfide and Polysulfides in Biological Samples

  • Shingo Kasamatsu,
  • Yuki Kakihana,
  • Taisei Koga,
  • Hisashi Yoshioka and
  • Hideshi Ihara

21 November 2020

Hydrogen sulfide (H2S) is endogenously produced by enzymes and via reactive persulfide/polysulfide degradation; it participates in a variety of biological processes under physiological and pathological conditions. H2S levels in biological fluids, suc...

  • Article
  • Open Access
32 Citations
6,434 Views
22 Pages

Oleacein Attenuates the Pathogenesis of Experimental Autoimmune Encephalomyelitis through Both Antioxidant and Anti-Inflammatory Effects

  • Beatriz Gutiérrez-Miranda,
  • Isabel Gallardo,
  • Eleni Melliou,
  • Isabel Cabero,
  • Yolanda Álvarez,
  • Prokopios Magiatis,
  • Marita Hernández and
  • María Luisa Nieto

21 November 2020

Oxidative stress and proinflammatory cytokines are factors affecting multiple sclerosis (MS) disease progression. Oleacein (OLE), an olive secoiridoid, possesses powerful antioxidant and anti-inflammatory activities, which suggests its potential appl...

  • Article
  • Open Access
18 Citations
5,598 Views
15 Pages

Nicotinamide Prevents Apolipoprotein B-Containing Lipoprotein Oxidation, Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice

  • Karen Alejandra Méndez-Lara,
  • Nicole Letelier,
  • Núria Farré,
  • Elena M. G. Diarte-Añazco,
  • Núria Nieto-Nicolau,
  • Elisabeth Rodríguez-Millán,
  • David Santos,
  • Victor Pallarès,
  • Joan Carles Escolà-Gil and
  • Tania Vázquez del Olmo
  • + 6 authors

21 November 2020

The potential of nicotinamide (NAM) to prevent atherosclerosis has not yet been examined. This study investigated the effect of NAM supplementation on the development of atherosclerosis in a mouse model of the disease. The development of aortic ather...

  • Article
  • Open Access
25 Citations
4,165 Views
17 Pages

21 November 2020

Sinapic acid (SA) is a naturally occurring phenolic compound with antioxidant properties. It also has a wide range of pharmacological properties, such as anti-inflammatory, anticancer, and hepatoprotective properties. The present study aimed to evalu...

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Antioxidants - ISSN 2076-3921Creative Common CC BY license