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Antioxidants, Volume 7, Issue 8

2018 August - 14 articles

Cover Story: The cytokine IL-1β, depending on the context, can contribute to neural injury as well as participate in neuroprotection/repair. We describe data demonstrating the ability of IL-1β to protect neural cells in vitro against reactive oxygen species, initiated by the addition of tert-butyl hydroperoxide (t-BOOH), involves an increase in the production/release of astrocyte glutathione (depicted in schema; created with BioRender). These protective effects were not strictly an in vitro phenomenon as we found that endogenous IL1-β signaling protects against 3-nitropropionic acid-mediated oxidative stress in vivo. View Paper here.
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Articles (14)

  • Article
  • Open Access
34 Citations
6,431 Views
11 Pages

Inhibitory Effects of Auraptene and Naringin on Astroglial Activation, Tau Hyperphosphorylation, and Suppression of Neurogenesis in the Hippocampus of Streptozotocin-Induced Hyperglycemic Mice

  • Satoshi Okuyama,
  • Tatsumi Nakashima,
  • Kumi Nakamura,
  • Wakana Shinoka and ,
  • Maho Kotani,
  • Atsushi Sawamoto,
  • Mitsunari Nakajima and
  • Yoshiko Furukawa
  • + 3 authors+ 0 author

19 August 2018

Auraptene, a citrus-related compound, exerts anti-inflammatory effects in peripheral tissues, and we demonstrated these effects in the brains of a lipopolysaccharide-injected systemic inflammation animal model and a brain ischemic mouse model. Naring...

(This article belongs to the Special Issue Phytochemical Antioxidants and Health)
  • Review
  • Open Access
140 Citations
26,375 Views
11 Pages

Evening Primrose (Oenothera biennis) Biological Activity Dependent on Chemical Composition

  • Magdalena Timoszuk,
  • Katarzyna Bielawska and
  • Elżbieta Skrzydlewska

14 August 2018

Evening primrose (Oenothera L.) is a plant belonging to the family Onagraceae, in which the most numerous species is Oenothera biennis. Some plants belonging to the genus Oenothera L. are characterized by biological activity. Therefore, studies were...

(This article belongs to the Special Issue Antioxidants and Second Messengers of Free Radicals)
  • Article
  • Open Access
50 Citations
9,723 Views
12 Pages

Mechanisms of LPS-Induced Acute Kidney Injury in Neonatal and Adult Rats

  • Egor Y. Plotnikov,
  • Anna A. Brezgunova,
  • Irina B. Pevzner,
  • Ljubava D. Zorova and ,
  • Vasily N. Manskikh,
  • Vasily A. Popkov,
  • Denis N. Silachev and
  • Dmitry B. Zorov
  • + 3 authors+ 0 author

Neonatal sepsis is one of the major causes of mortality and morbidity in newborns, greatly associated with severe acute kidney injury (AKI) and failure. Handling of newborns with kidney damage can be significantly different compared to adults, and it...

  • Review
  • Open Access
19 Citations
5,453 Views
9 Pages

Redox Biology of Right-Sided Heart Failure

  • Nataliia V. Shults,
  • Oleksiy Melnyk,
  • Dante I. Suzuki and
  • Yuichiro J. Suzuki

Right-sided heart failure is the major cause of death among patients who suffer from various forms of pulmonary hypertension and congenital heart disease. The right ventricle (RV) and left ventricle (LV) originate from different progenitor cells and...

(This article belongs to the Special Issue Novel Aspects of Redox, Antioxidant and Mitochondrial Signaling)
  • Review
  • Open Access
56 Citations
14,112 Views
12 Pages

Mitochondria-Targeted Antioxidants and Skeletal Muscle Function

  • Sophie C. Broome,
  • Jonathan S. T. Woodhead and
  • Troy L. Merry

One of the main sources of reactive oxygen species (ROS) in skeletal muscle is the mitochondria. Prolonged or very high ROS exposure causes oxidative damage, which can be deleterious to muscle function, and as such, there is growing interest in targe...

(This article belongs to the Special Issue Feature Papers in Antioxidants in 2018)
  • Article
  • Open Access
8 Citations
5,082 Views
7 Pages

The current study aimed to evaluate, in vitro, the antioxidant capacity and the human lymphocyte-protective effect of the ethanolic extract from Detarium microcarpum fruit pulp against oxidative stress damage. Human lymphocytes were incubated with di...

  • Article
  • Open Access
21 Citations
7,668 Views
13 Pages

Solvent Extraction of Polyphenolics from the Indigenous African Fruit Ximenia caffra and Characterization by LC-HRMS

  • Dewald Oosthuizen,
  • Neill J. Goosen,
  • Maria A. Stander,
  • Aliyu D. Ibrahim and ,
  • Mary-Magdalene Pedavoah,
  • Grace O. Usman and
  • Taiwo Aderinola
  • + 2 authors+ 0 author

Indigenous and non-commercial fruits can be an important source of antioxidant polyphenols; however, the identity and content of polyphenols from non-commercial fruits are often poorly described. The study aimed to extract, identify, and quantify pol...

  • Review
  • Open Access
313 Citations
19,066 Views
17 Pages

Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related Disorders

  • Giuseppina Barrera,
  • Stefania Pizzimenti,
  • Martina Daga,
  • Chiara Dianzani and ,
  • Alessia Arcaro,
  • Giovanni Paolo Cetrangolo,
  • Giulio Giordano,
  • Marie Angele Cucci,
  • Maria Graf and
  • Fabrizio Gentile
  • + 5 authors+ 0 author

Among the various mechanisms involved in aging, it was proposed long ago that a prominent role is played by oxidative stress. A major way by which the latter can provoke structural damage to biological macromolecules, such as DNA, lipids, and protein...

(This article belongs to the Special Issue Antioxidants and Second Messengers of Free Radicals)
  • Editorial
  • Open Access
4 Citations
4,611 Views
3 Pages

Since the advent of modern nanotechnology a couple of decades ago, the field of “nano-bio-med” has attracted particular interest, culminating in an almost meteoric rise of common, feasible, more speculative, and, on occasion, outrightly e...

(This article belongs to the Special Issue Inspired by Nature: Antioxidants and Nanotechnology)
  • Article
  • Open Access
25 Citations
6,514 Views
11 Pages

The study aims to examine the effects of coenzyme Q10, (a bioenergetic antioxidant), on the indexes of left ventricular remodeling, oxidative damage, and angiotensin-converting enzyme (ACE) level after acute myocardial infarction (AMI) with left vent...

(This article belongs to the Special Issue CoQ10 in Longevity)
  • Article
  • Open Access
18 Citations
6,521 Views
15 Pages

Interleukin-1β Protects Neurons against Oxidant-Induced Injury via the Promotion of Astrocyte Glutathione Production

  • Twinkle Chowdhury,
  • Matthew F. Allen,
  • Trista L. Thorn,
  • Yan He and
  • Sandra J. Hewett

Interleukin-1β (IL-1β), a key cytokine that drives neuroinflammation in the Central Nervous System (CNS), is enhanced in many neurological diseases/disorders. Although IL-1β contributes to and/or sustains pathophysiological processes i...

(This article belongs to the Special Issue Astrocyte Antioxidant Systems)
  • Article
  • Open Access
61 Citations
8,281 Views
13 Pages

Consumption of food containing n-3 PUFAs, namely EPA and DHA, are known to benefit health and protect against chronic diseases. Both are richly found in marine-based food such as fatty fish and seafood that are commonly cooked prior to consumption. H...

(This article belongs to the Special Issue Lipid Peroxidation: Analysis and Applications in Biological Systems)
  • Review
  • Open Access
458 Citations
27,426 Views
13 Pages

Cerium oxide nanoparticles (CeNPs) exhibit antioxidant properties both in vitro and in vivo. This is due to the self-regeneration of their surface, which is based on redox-cycling between 3+ and 4+ states for cerium, in response to their immediate en...

(This article belongs to the Special Issue Feature Papers in Antioxidants in 2018)
  • Review
  • Open Access
547 Citations
29,814 Views
14 Pages

Wound healing is a well-tuned biological process, which is achieved via consecutive and overlapping phases including hemostasis, inflammatory-related events, cell proliferation and tissue remodeling. Several factors can impair wound healing such as o...

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Antioxidants - ISSN 2076-3921