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Antioxidants, Volume 7, Issue 8

August 2018 - 14 articles

Cover Story: The cytokine IL-1β, depending on the context, can contribute to neural injury as well as participate in neuroprotection/repair. We describe data demonstrating the ability of IL-1β to protect neural cells in vitro against reactive oxygen species, initiated by the addition of tert-butyl hydroperoxide (t-BOOH), involves an increase in the production/release of astrocyte glutathione (depicted in schema; created with BioRender). These protective effects were not strictly an in vitro phenomenon as we found that endogenous IL1-β signaling protects against 3-nitropropionic acid-mediated oxidative stress in vivo. View Paper here.
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Articles (14)

  • Article
  • Open Access
30 Citations
5,865 Views
11 Pages

Inhibitory Effects of Auraptene and Naringin on Astroglial Activation, Tau Hyperphosphorylation, and Suppression of Neurogenesis in the Hippocampus of Streptozotocin-Induced Hyperglycemic Mice

  • Satoshi Okuyama,
  • Tatsumi Nakashima,
  • Kumi Nakamura,
  • Wakana Shinoka,
  • Maho Kotani,
  • Atsushi Sawamoto,
  • Mitsunari Nakajima and
  • Yoshiko Furukawa

19 August 2018

Auraptene, a citrus-related compound, exerts anti-inflammatory effects in peripheral tissues, and we demonstrated these effects in the brains of a lipopolysaccharide-injected systemic inflammation animal model and a brain ischemic mouse model. Naring...

  • Review
  • Open Access
117 Citations
22,657 Views
11 Pages

Evening Primrose (Oenothera biennis) Biological Activity Dependent on Chemical Composition

  • Magdalena Timoszuk,
  • Katarzyna Bielawska and
  • Elżbieta Skrzydlewska

14 August 2018

Evening primrose (Oenothera L.) is a plant belonging to the family Onagraceae, in which the most numerous species is Oenothera biennis. Some plants belonging to the genus Oenothera L. are characterized by biological activity. Therefore, studies were...

  • Article
  • Open Access
43 Citations
8,611 Views
12 Pages

Mechanisms of LPS-Induced Acute Kidney Injury in Neonatal and Adult Rats

  • Egor Y. Plotnikov,
  • Anna A. Brezgunova,
  • Irina B. Pevzner,
  • Ljubava D. Zorova,
  • Vasily N. Manskikh,
  • Vasily A. Popkov,
  • Denis N. Silachev and
  • Dmitry B. Zorov

Neonatal sepsis is one of the major causes of mortality and morbidity in newborns, greatly associated with severe acute kidney injury (AKI) and failure. Handling of newborns with kidney damage can be significantly different compared to adults, and it...

  • Review
  • Open Access
18 Citations
4,901 Views
9 Pages

Redox Biology of Right-Sided Heart Failure

  • Nataliia V. Shults,
  • Oleksiy Melnyk,
  • Dante I. Suzuki and
  • Yuichiro J. Suzuki

Right-sided heart failure is the major cause of death among patients who suffer from various forms of pulmonary hypertension and congenital heart disease. The right ventricle (RV) and left ventricle (LV) originate from different progenitor cells and...

  • Review
  • Open Access
41 Citations
12,083 Views
12 Pages

Mitochondria-Targeted Antioxidants and Skeletal Muscle Function

  • Sophie C. Broome,
  • Jonathan S. T. Woodhead and
  • Troy L. Merry

One of the main sources of reactive oxygen species (ROS) in skeletal muscle is the mitochondria. Prolonged or very high ROS exposure causes oxidative damage, which can be deleterious to muscle function, and as such, there is growing interest in targe...

  • Article
  • Open Access
8 Citations
4,631 Views
7 Pages

The current study aimed to evaluate, in vitro, the antioxidant capacity and the human lymphocyte-protective effect of the ethanolic extract from Detarium microcarpum fruit pulp against oxidative stress damage. Human lymphocytes were incubated with di...

  • Article
  • Open Access
19 Citations
5,997 Views
13 Pages

Solvent Extraction of Polyphenolics from the Indigenous African Fruit Ximenia caffra and Characterization by LC-HRMS

  • Dewald Oosthuizen,
  • Neill J. Goosen,
  • Maria A. Stander,
  • Aliyu D. Ibrahim,
  • Mary-Magdalene Pedavoah,
  • Grace O. Usman and
  • Taiwo Aderinola

Indigenous and non-commercial fruits can be an important source of antioxidant polyphenols; however, the identity and content of polyphenols from non-commercial fruits are often poorly described. The study aimed to extract, identify, and quantify pol...

  • Review
  • Open Access
244 Citations
15,591 Views
17 Pages

Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related Disorders

  • Giuseppina Barrera,
  • Stefania Pizzimenti,
  • Martina Daga,
  • Chiara Dianzani,
  • Alessia Arcaro,
  • Giovanni Paolo Cetrangolo,
  • Giulio Giordano,
  • Marie Angele Cucci,
  • Maria Graf and
  • Fabrizio Gentile

Among the various mechanisms involved in aging, it was proposed long ago that a prominent role is played by oxidative stress. A major way by which the latter can provoke structural damage to biological macromolecules, such as DNA, lipids, and protein...

  • Article
  • Open Access
25 Citations
5,442 Views
11 Pages

The study aims to examine the effects of coenzyme Q10, (a bioenergetic antioxidant), on the indexes of left ventricular remodeling, oxidative damage, and angiotensin-converting enzyme (ACE) level after acute myocardial infarction (AMI) with left vent...

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Antioxidants - ISSN 2076-3921Creative Common CC BY license