Next Article in Journal
Mitochondria-Targeted Antioxidants and Skeletal Muscle Function
Next Article in Special Issue
Effects of Bcl-2/Bcl-xL Inhibitors on Pulmonary Artery Smooth Muscle Cells
Previous Article in Journal
Mechanisms of LPS-Induced Acute Kidney Injury in Neonatal and Adult Rats
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview
Antioxidants 2018, 7(8), 106;

Redox Biology of Right-Sided Heart Failure

Department of Pharmacology and Physiology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20007, USA
Author to whom correspondence should be addressed.
Received: 25 June 2018 / Revised: 21 July 2018 / Accepted: 7 August 2018 / Published: 8 August 2018
(This article belongs to the Special Issue Novel Aspects of Redox and Antioxidant Signaling)
Full-Text   |   PDF [999 KB, uploaded 8 August 2018]   |  


Right-sided heart failure is the major cause of death among patients who suffer from various forms of pulmonary hypertension and congenital heart disease. The right ventricle (RV) and left ventricle (LV) originate from different progenitor cells and function against very different blood pressures. However, differences between the RV and LV formed after birth have not been well defined. Work from our laboratory and others has accumulated evidence that redox signaling, oxidative stress and antioxidant regulation are important components that define the RV/LV differences. The present article summarizes the progress in understanding the roles of redox biology in the RV chamber-specificity. Understanding the mechanisms of RV/LV differences should help develop selective therapeutic strategies to help patients who are susceptible to and suffering from right-sided heart failure. Modulations of redox biology may provide effective therapeutic avenues for these conditions. View Full-Text
Keywords: antioxidants; redox; reactive oxygen species; right heart failure antioxidants; redox; reactive oxygen species; right heart failure

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Shults, N.V.; Melnyk, O.; Suzuki, D.I.; Suzuki, Y.J. Redox Biology of Right-Sided Heart Failure. Antioxidants 2018, 7, 106.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top