Special Issue "Astrocyte Antioxidant Systems"
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: closed (31 May 2017)
Prof. Dr. Gethin J. McBean
UCD School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland
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Interests: mechanisms of action of antioxidants in the brain; Particularly, the importance of sulfur-containing amino acids in thiol redox balance and antioxidant defence in astrocytes and microglial cells
Astrocytes play an essential role in protecting the brain from oxidative stress, particularly in the context of providing antioxidant support for neurons. Several species of antioxidant, including thiol-based antioxidants and phase II antioxidant enzymes, which include heme oxygenase-1, NAD(P)H: quinone oxidoreductase, manganese superoxide dismutase and catalase are expressed in astrocytes. In the past 10–15 years, details have emerged of how astrocytes are responsible for the de novo synthesis of antioxidants, and for mediating the transfer of the components of major antioxidant molecules, such as glutathione, to neurons. Much remains to be discovered of how antioxidant production in astrocytes is regulated and how these cells respond to oxidative stress to boost their antioxidant capacity and neuroprotective function.
This Special Issue will publish original research papers and reviews on aspects of astrocyte antioxidants that relate to the following topics: the function and regulation of antioxidants in astrocytes; understanding the pathways of thiol redox homeostasis and of provision of precursors for antioxidant synthesis; the relationship between astrocyte antioxidants and neuroprotection; agents that promote the antioxidant capacity of astrocytes; and the potential of antioxidant systems in astrocytes as a therapeutic target.
Prof. Dr. Gethin McBean
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Transcription factor Nrf2
- NAD(P)H:quinone oxidoreductase
- Superoxide dismutase